Research Opportunities

Translational Research Program (TRP)

The Translational Research Program (TRP) seeks to promote the research and educational missions of the Department of Pathology by providing financial, intellectual and human resources to facilitate clinically relevant, high-impact research. Our overall goals are to to prepare trainees for careers in pathology by cultivating their interest in research and critical reading of the medical literature, to promote collaborations among members of the Department of Pathology and other departments, to promote the development of investigator-initiated projects, and to promote a culture of discovery and innovation.

  • How does the the program work?
    Pathology Residents and Fellows submit proposals to the program for consideration, and the TRP funds the best research projects; all proposals must be sponsored by a faculty member in the Department of Pathology. The program sponsors bi-annual research "blitzes", that allow trainers and faculty members to find research projects of mutual interest. Awardees have the opportunity to present their ongoing work at monthly Work-in-Progress (WIP) seminars and receive valuable feedback from their colleagues. The WIP conference takes place the 3rd Friday of the month. Click here to check the current calendar.
     
  • What services do we provide?
    We serve as a liaison between the Department and the NYU administration and can advise trainees/faculty through TRP application process as well as through the IRB application process. TRP support includes administration of research funds following project approval, as well as active monitoring of project outcomes.
     

Partial list of currently funded projects (2018-2019):

  • Diagnostic utility of EZH2 immunostain in mammary apocrine lesions
  • Impact of NF1 mutation on response and toxicity to immunotherapy in melanoma
  • Methylation profiling of histologic subtypes of renal cell carcinoma<
  • Development and adult anatomy of the human interstitium
  • Immune checkpoint pathways in heart transplant rejection

Please contact us with questions or comments.

Christopher Park, MD, PhD
Director
christopher.park@nyunlangone.org

Caterina Berti, PhD
Manager Research Laboratory Operations
caterina.berti@nyulangone.org

Resources

NYU Translational Pathology Proposal Template
2019-2020 Translational Research Program WIP Schedule

 

Recent Publications

Basu A, Boczek NJ, Robertson ng, Nasir SH, McPhail ED, Kurtin PJ, Dasari S, Butz M, Morton CC, Highsmith WE, Zhou F. First report of bilateral external auditory canal cochlin aggregates (“cochlinomas”) with multifocal amyloid-like deposits, associated with sensorineural hearing loss and a novel genetic variant in COCH encoding cochlin. Head and Neck Pathology 2019 Sep 6.

Basu A, Moreira AL, Simms A, Brandler TC. Sarcomatoid carcinoma in cytology: Report of a rare entity presenting in pleural and pericardial fluid preparations. Diagn Cytopathol. 2019 Aug;47(8):813-816.

Schwartz CJ, Dolgalev I, Yoon E, Osman I, Heguy A, Vega-Saenz de Miera EC, Nimeh D, Jour G, Darvishian F. Microglandular adenosis is an advanced precursor breast lesion with evidence of molecular progression to matrix-producing metaplastic carcinoma. Hum Pathol. 2019 Mar;85:65-71.

Cho M, Acosta-Gonzalez G, Brandler TC, Basu A, Wei XJ, Simms A. Papillary thyroid carcinoma metastatic to the pancreas: Case report. Diagn Cytopathol. 2019 Mar;47(3):214-217.

Li FQ, Chiriboga L, Black MA, Takemaru KI, Raffaniello RD. Chibby is a weak regulator of β-catenin activity in gastric epithelium. J Cell Physiol. 2019 Feb;234(2):1871-1879.

Zhao Y, Deng FM, Huang H, Lee P, Lepor H, Rosenkrantz AB, Taneja S, Melamed J, Zhou M. Prostate Cancers Detected by MRI Targeted Biopsies Have A Higher Percentage Of Gleason Pattern 4 Component And Are Less Likely To Be Upgraded In Radical Prostatectomies. Arch Pathol Lab Med 2019 Jan;143(1):86-91.

Coudray N, Ocampo PS, Sakellaropoulos T, Narula N, Snuderl M, Fenyö D, Moreira AL, Razavian N, Tsirigos A. Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning. Nat Med. 2018 Oct;24(10):1559-1567.

Schwartz CJ, Schandl CA, Morse J, Ralston J, Rapkiewicz A, Darvishian F. Benign Fibromyxoid Lesion of the Breast: A Distinct Entity From Benign Spindle Cell Tumors of the Mammary Stroma? Int J Surg Pathol. 2018 Sep;26(6):488-493.

Lau RP, Paulsen JD, Brandler TC, Liu CZ, Simsir A, Zhou F. Impact of the Reclassification of "Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma" to "Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features" on the Bethesda System for Reporting Thyroid Cytopathology: A Large Academic Institution's Experience. Am J Clin Pathol. 2017 Dec 20;149(1):50-54.

Brandler TC, Zhou F, Liu CZ, Cho M, Lau RP, Simsir A, Patel KN, Sun W. Can noninvasive follicular thyroid neoplasm with papillary-like nuclear features be distinguished from classic papillary thyroid carcinoma and follicular adenomas by fine-needle aspiration? Cancer Cytopathol. 2017 Jun;125(6):378-388.

Drummond E, Nayak S, Faustin A, Pires G, Hickman RA, Askenazi M, Cohen M, Haldiman T, Kim C, Han X, Shao Y, Safar JG, Ueberheide B, Wisniewski T. Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease. Acta Neuropathol. 2017 Jun;133(6):933-954.

Hickman RA, Yu H, Li J, Kong M, Shah RB, Zhou M, Melamed J, Deng FM. Atypical Intraductal Cribriform Proliferations of the Prostate Exhibit Similar Molecular and Clinicopathologic Characteristics as Intraductal Carcinoma of the Prostate. Am J Surg Pathol. 2017 Apr;41(4):550-556.

 

Recent Presentations

Schwartz C, Snuderl M, Jour G, Darvishian F. Breast Cancers with Micropapillary/Tubulopapillary Morphology Demonstrate Frequent DNAH9 Mutations. USCAP, National Harbor, MD, 2019. Platform presentation.

Allison D, Sun K, Suarez Y, Young GQ, Xu R, Cao W, Sarkar S. Early Onset Colorectal Adenocarcinomas are More Likely to Have Poor Prognostic Features: In Support of the New ACS Colorectal Cancer Screening Guidelines. USCAP, National Harbor, MD, 2019. Platform presentation.

Hernandez A, Chen F, Brandler T, Zhou F, Xia Y, Zhong J, Moreira A, Simms A, Wei X, Sun W, Simsir A. Scoring of Programmed Death-Ligand 1 (PD-L1) Immunohistochemistry (IHC) on Cytology Specimens in Non-Small Cell Lung Carcinoma (NSCLC): An Inter-observer Agreement Study. USCAP, National Harbor, MD, 2019. Platform presentation.

Schwartz C, Dolgalev I, Heguy A, Snuderl M, Jour G, Darvishian F. Multifocal Breast Cancer: A Clonality Study Using Whole Exome Sequencing. USCAP, National Harbor, MD, 2019.

Lytle A, Darvishian F, Ozerdem U. Localized Amyloidosis: A Diagnostic Pitfall in Breast Biopsies. USCAP, National Harbor, MD, 2019.

Vougiouklakis T, Schwartz C, Cotzia P, Snuderl M, Jour G, Darvishian F. BAP1 Loss in Triple Negative Breast Cancer. USCAP, National Harbor, MD, 2019.

Schwartz C, Snuderl M, Jour G, Darvishian F. Molecular Analysis of Triple-Negative Breast Cancers Reveals Diverse Mutational Events in Chromatin Regulation Genes. USCAP, National Harbor, MD, 2019.

Basu A, Narula N, Simms A, Shirsat H, Zhou F, Moreira A. Association of PD-L1 Expression with Histological Grade and Mutational Profile in Lung Adenocarcinoma. USCAP, National Harbor, MD, 2019.

Ahmed S, Xu R. The Frequency of Celiac Disease in Patients with Unexpected Intraepithelial Lymphocytosis in Duodenal Biopsy Specimen in a Tertiary Hospital. USCAP, National Harbor, MD, 2019.

Imam R, Black M, Xu R, Cao W. Expression of CD47 in Gastroenteropancreatic Neuroendocrine Tumor is Related to Lymph Node Metastasis, a Potential Indicator for Poor Prognosis. USCAP, National Harbor, MD, 2019.

Black M, Adler E, Neto A. Gastrointestinal Tract Plasmablastic Lymphoma: Immunomorphologic Characterization of an Elusive Entity. USCAP, National Harbor, MD, 2019.

Black M, Jour G, Snuderl M. Chromatin Remodeling and DNA Repair in Intrahepatic Cholangiocarcinoma: A Possible Driver of Tumorigenesis. USCAP, National Harbor, MD, 2019.

Paulsen JD, Zeck B, Chiriboga L, Sun K, Theise N. Co-Expression of Keratin 19 and Mesenchymal Markers for Evaluation of Epithelial-Mesenchymal Transition and Stem Cell Niche Components in Primary Biliary Cholangitis (PBC). USCAP, National Harbor, MD, 2019.

Belovarac B, Liu C, Brandler T. Molecular Features of Thyroid Hurthle Cell Lesions: Can pre-surgical Molecular Analysis by ThyroSeq and Afirma differentiate Benign vs. Malignant Hurthle cell nodules? USCAP, National Harbor, MD, 2019.

Vargas A, Black M, Ren Q, Huang H, Melamed J, Deng F. Histopathologic Findings in Orchiectomy Specimens for Gender Confirmation Surgery. USCAP, National Harbor, MD, 2019.

Chen F, Isaila B, Parimi (Parini) V, Ren Q, Park K, Huang H, Deng F, Melamed J. Can Gleason Grade be Reliably Assigned Based on the Perineural Focus of Adenocarcinoma? USCAP, National Harbor, MD, 2019.

Chen F, Ren Q, Levy D, Lee P, Deng F, Melamed J. STAT3 Phosphorylation at Ser727 is involved in prostate carcinogenesis and is associated with increased disease-associated mortality. USCAP, National Harbor, MD, 2019.

Parimi (Parini) V, Xia Y, Mezzano V, Vasudevaraja V, Selvaraj S, Loomis C, Moreira A, Peng Lee P, Levy D, Park K, Huang H, Ren Q, Deng F, Melamed J. Integrated Expression (Chromogenic in situ Hybridization) of Long Noncoding RNAs (LncRNAs) Segregate Low Grade from Clinically Significant Prostate Cancer. USCAP, National Harbor, MD, 2019.

Parimi (Parini) V, Vasudevaraja V, Xia Y, Selvaraj S, Mezzano V, Jour G, Snuderl M, Tsirigos A, Deng F, Melamed J. Long Noncoding RNAs (LncRNAs) Signatures in Prostate Cancer: External Validation with The Cancer Genome Atlas (TCGA) database. USCAP, National Harbor, MD, 2019.

Paulsen JD, Zamuco R, Melamed J, Shukla P. Immunohistochemical Characterization of Squamous Cell Carcinoma of Different Organs. USCAP, National Harbor, MD, 2019.