Dynlacht Lab Available Positions
The Dynlacht Lab is growing its dynamic team of researchers. See current job openings below.
Research Technician/Lab Manager
We are recruiting a motivated, independent, and organized full-time research technician. Duties are varied and include organizing and ordering laboratory supplies; preparing stock reagents; and assisting members of the laboratory with their experiments.
Prior experience in molecular biological and biochemical techniques is preferred, but not necessary.
This position requires managing many different responsibilities; as such, strong time management and organizational skills are essential. Candidates must have a minimum of a BS in biochemistry or related field. A commitment of at least two years is a prerequisite for the position.
Full health benefits are provided.
Our lab meetings are always open to prospective graduate students. All Vilcek Institute of Graduate Biomedical Sciences "open program" students are expected to complete a research rotation of approximately three months. Students who wish to stay longer to complete a project will be accommodated.
Email Dr. Dynlacht for more details.
We have immediate openings for postdoctoral fellows on two projects.
Epigenetics and Gene Expression of Muscle Stem Cell Biology
We use a combination of biochemical, genomic, and computational methods to dissect the epigenetic controls that govern cell cycle progression and mammalian differentiation. Using muscle differentiation as a model, we are attempting to unravel mechanisms that underlie the transition between growth and terminal differentiation. Using muscle stem cells and muscle progenitors, we are also attempting to reveal the epigenetic controls that determine whether a cell will remain pluripotent or adopt one mesodermal fate versus another.
We are exploring the topological changes in the three-dimensional landscape of muscle stem cells by examining how interactions between genomic regions are rewired during differentiation into muscle cells. Our laboratory has a twenty-plus-year commitment to understanding the role of chromatin and gene expression in cell proliferation and differentiation using stem cell and breast cancer models.
Toward this effort, we are seeking candidates experienced in molecular biology to develop novel approaches for analyzing protein–chromatin interactions and epigenetic control of differentiation. Expertise with chromatin, gene expression, or transcription is preferred but not essential. The ideal candidate will help develop state-of-the-art and cutting-edge approaches toward understanding the role of protein interactions in assembly and activation of regulatory elements and gene activation and repression. As an example of the research we perform in the lab, applicants are encouraged to read our latest paper on the topic, published in Nature Communications.
We are most interested in employing a combination of molecular biology, biochemistry, and computational methods to understand how chromatin topology is regulated in muscle stem cells. For this project, candidates must have a PhD in molecular biology, biochemistry, or a related field and a strong interest in gene expression, chromatin, or both. Experience with computational methods, bioinformatics, and computer languages (for example, Python, R) is a plus, as we seek to employ cutting-edge genomics and computational approaches. Highly interactive researchers are encouraged to apply.
The Role of Primary Cilia as Tumor Suppressive Organelles
We are focusing on understanding the molecular controls that promote and suppress ciliogenesis, which plays a pivotal role in cell cycle progression and mitosis. The cilium is a key signaling organelle, and the presence of a primary cilium is associated with quiescence and differentiation. Defects in this structure are associated with many human developmental diseases and cancer. Yet the switching mechanisms that convert centrosomes to a primary cilium from which it is derived are not known.
We are interested in several basic science questions, including how primary cilia are normally assembled, postranslational regulation of tubulins and what suppresses their formation in growing cells, and how these controls are subverted in pancreatic and breast cancers. We have performed genome-wide screens to uncover genes whose expression causes the loss of cilia and are now taking cell biological approaches toward uncovering the mechanisms underlying their function, with the hope of developing novel therapeutic strategies to suppress aberrant proliferation in cancer cells. For this project, a strong interest and experience in cell biological methods, specifically microscopy, and molecular biology is preferred. As an example of ongoing research on this project, applicants are encouraged to read our latest paper on the topic, published in Molecular Biology of the Cell.
Postdoctoral Fellowship Eligibility
Candidates for postdoctoral positions must have a PhD in molecular biology, biochemistry, or a related field, and a strong interest in cell biology, cancer biology, or both.
Most postdoctoral fellows at NYU Grossman School of Medicine are eligible for comprehensive benefits.
If you are interested in a postdoctoral position, please send a CV and a description of your interests to Dr. Dynlacht at firstname.lastname@example.org.