Nuclear receptors are ligand-regulated transcription factors that control diverse physiological and developmental processes. In the Garabedian Lab at NYU Langone, investigators aim to understand the mechanism of signal transduction and transcriptional regulation by nuclear hormone receptors, including LXR alpha in cardiovascular disease, the glucocorticoid receptor (GR) in immune and neuronal function, and the androgen receptor (AR) in prostate cancer.

Our key research interests include the resolution of inflammation by nuclear receptors in innate and adaptive immune cells; new prostate cancer therapeutics (such as peptoid conjugates and immune checkpoint blockade inhibitors); the molecular mechanism of glucocorticoid receptor action in neuronal function during stress; and transcriptional and epigenetic regulation by nuclear receptors in macrophages.

We use state-of-the-art genetic approaches including CRISPR and siRNA screens and sophisticated knock-in mouse models, as well as molecular, genomic (single cell RNA-seq, spatial transcriptomics, ChIP-seq, and ATAC-seq), proteomic, and metabolomic approaches to discover novel insights into the mechanisms of nuclear receptors and other transcriptional regulatory factors in disease. Our goal is to leverage this information for potential clinical applications in prostate cancer, atherosclerosis, stress-related anxiety, and depression.

The laboratory and training environment has always promoted an inclusive, safe, and supportive research environment. Our lab is part of the Logan Lab, led by Susan K. Logan, PhD, Associate Professor, Departments of Urology and Biochemistry and Molecular Pharmacology.

Contact Us

Michael J. Garabedian, PhD
Principal Investigator
Professor, Departments of Microbiology and Urology
Alexandria Center for Life Science – East Tower
450 East 29th Street, Room 324
Office Phone: 212-263-7662
Fax: 646-501-4643
Lab Phone: 212-263-7968
Email: michael.garabedian@nyulangone.org