Giannarelli Lab Research
T-Cell Plasticity in Vascular Disease
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T-Cell Plasticity in Vascular Disease
Giannarelli Lab investigators study how T-cell heterogeneity and T-cell plasticity in atherosclerotic plaques contributes to plaque vulnerability and cardiovascular events in patients.
We focus on CD8+ T-cell biology in atherosclerosis, combining single-cell studies in human tissue with CRISPR/Cas9 screens with sophisticated mouse models of atherosclerosis.
Other projects focus on CD4 and other T-cell types and functional states found in human plaques.