Residency in Laboratory Animal Medicine

 

New York University-Regeneron Post-Doctoral Training Program in Laboratory Animal Medicine

Participating Institutions | Curriculum | Didactic Training | Clinical Training | Regulatory Training | Research

New York University Washington Square (NYUWS), NYU Langone Health (NYULH) and Regeneron Pharmaceuticals, Inc. are proud to support an American College of Laboratory Animal Medicine (ACLAM) recognized three year post-doctoral training program in Laboratory Animal Medicine. The combined NYU-Regeneron training program is led by eight ACLAM boarded veterinarians and six ACVP boarded veterinary pathologists. While rotating between the three supporting institutions veterinary postdocs will have the opportunity to work with a diversity of species including primary, secondary and tertiary species as defined in the ACLAM Role Delineation Document. Veterinary postdocs will also have the opportunity to experience and appreciate organizational, managerial and operational differences between the three institutions. The combined NYU-Regeneron experience ensures that postdocs are provided with a dynamic training experience that will help prepare them for the many career paths available in laboratory animal medicine.

Graduates of AVMA-accredited schools of veterinary medicine with a strong interest in laboratory animal medicine are encouraged to apply. The NYU-Regeneron Program would also like to announce that externship experiences are now also available for interested first through fourth year veterinary students.  

Participating Institutions

NYULH (an academic medical center) and NYUWS research, teaching and testing programs include but are not limited to: neuroscience and behavior, microbiology, immunology, cancer, cardiology, surgery, diagnostic imaging, and endocrinology. The NYU School of Medicine, a division of NYULH, ranked No. 3 in the nation in U.S. News & World Report’s 2019 ‘Best Graduate Schools’ rankings for research.

Regeneron Pharmaceuticals, Inc. is a leading science-based, fully integrated biopharmaceutical company that discovers, develops, manufactures and commercializes medicines for the treatment of serious medical conditions. Regeneron markets medicines for eye diseases, colorectal cancer, and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including hypercholesterolemia, rheumatoid arthritis and asthma.  

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Curriculum Overview

The primary objective of the NYU-Regeneron training program is to help provide veterinary postdoctoral fellows with the skills and knowledge base necessary to become competent laboratory animal veterinarians and to ultimately pursue successful careers in academia or industry. Specific training objectives include but are not limited to:

  1. The development of clinical competence when working with commonly used laboratory animal species.
  2. Understanding of the regulations and requirements inherent in animal research.
  3. Completion of a hypothesis-driven, first authored research project resulting in a peer-reviewed journal publication.
  4. Further development of public speaking and presentation skills through teaching and lecture opportunities provided during in-house seminars as well as at local and national conferences.
  5. The ability to perform a necropsy and to accurately provide gross morphologic descriptions of pathological lesions.
  6. Gaining an understanding of laboratory animal facility management including an introduction into staff management through opportunities provided for personnel oversight.
  7. The development of one-on-one communication skills while working with investigative staff in the creation and review of research protocols or while providing clinical oversight and/or training.
  8. The opportunity to actively participate on IACUC committees as an alternate member.
  9. Obtaining Diplomate status in the American College of Laboratory Animal Medicine.

To successfully meet all training objectives the NYU-Regeneron training program is divided into four fundamental components. Scheduled didactic training, the first component, occurs weekly throughout the 3-year training program. Didactic training sessions are designed to provide trainees with the knowledge base needed to obtain Diplomate status in the American College of Laboratory Animal Medicine.

Laboratory animal clinical training is the second training component and occurs throughout the training program on a rotation basis. Laboratory animal clinical training encompasses anesthesia, surgery, pre and post-operative care, necropsy, pathology, preventative medicine, husbandry, enrichment and behavior focusing on commonly used laboratory animal species. Clinical rotations are divided between the three program locations. Because the NYU-Regeneron training program has the combined benefit of having three participating institutions, each institution is able to offer trainees additional clinical experiences unique to each training location. As an example, Regeneron Pharmaceuticals Inc. provides trainees with exposure to large-scale rodent production, facility design and management training while providing a clinical introduction to the Biotech/Pharma experience.

Regulatory training is the third component of the training program. Postdoctoral fellows are expected to participate in at least one monthly IACUC meeting and will be assigned to participate either as an alternate member or in an observational role throughout the duration of the 3-year program. Postdocs will be expected to routinely review IACUC protocols and to discuss reviews with assigned veterinary IACUC mentors. Postdocs may also be asked to participate in semiannual inspections, regulatory and compliance meetings.

The fourth and final component of the NYU-Regeneron training program is the research rotation. During the research rotation postdoctoral fellows are allocated a period of 12 months to design and successfully execute a research project. Postdocs are strongly encouraged to pursue their research rotation during the second year of the training program. An ACLAM-certified member of the program faculty will serve as the primary research mentor, or alternatively research mentorship will be assigned to a suitable faculty member willing and qualified to oversee the research project. Research projects that directly benefit the field of laboratory animal medicine will be strongly encouraged. At the end of the third year, after completion of all four program components, trainees are awarded a certificate of completion.  

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Scheduled Didactic Training

The Seminar Series occurs once weekly and consists of lecture modules organized by species, or another relevant lab animal topic and is scheduled over the duration of the 3-year training program. Seminars are prepared and delivered by both program faculty and postdoctoral fellows.

Clinical and Pathology rounds take place weekly and encompass either current or historical clinical cases with accompanying clinical and/or anatomic pathology as presented by trainee(s) or faculty.

Journal club occurs on a bi-weekly basis. Journal articles are presented by either program faculty or postdoctoral fellows and focus on topical research manuscripts from JAALAS or Comp Med, or other laboratory animal medicine relevant journal sources.

Formal Course Work is undertaken during the first two years of the training program. Course work consists of three required courses: Scientific Integrity and the Responsible Conduct of Research, Immunology and a required Academic Writing course which can be coordinated in conjunction with scientific manuscript preparation. 

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Laboratory Animal Clinical Training

Postdoctoral fellows divide clinical rotation time between the three training facility locations (Regeneron, NYU Langone Health, NYU Washington Square). All clinical rotations are supervised by a clinical veterinarian or ACLAM boarded faculty member. Laboratory animal clinical training provides postdocs with the opportunity to develop the technical and clinical skill sets needed to handle and perform basic tasks such as sample collection from common laboratory animal species, expertise in laboratory animal disease diagnosis, treatment, and control (including concepts in biosecurity) and the skills necessary to anesthetize various laboratory animal species and manage complex experimental surgical procedures including pre-and post-operative care. As a clinical supplement, six additional clinical weeks are provided for elective rotations either at hosting institutions or through program-approved externship locations.

Throughout clinical training postdocs will have opportunities to interact directly with investigators and/or research staff and will learn to confidently convey clinical observations and proposed treatment plans. Alternatively postdocs may be asked to lead meetings to help address investigator problems or concerns, and also to help negotiate a collaborative resolutions for common problems. During the clinical rotations postdocs will also have opportunities to utilize training skills while providing hands-on workshops, lectures and one-on-one trainings to new and seasoned investigative staff. As each trainee(s) advances within the training program they will be provided with increasing primary contact responsibility with guidance from faculty members as necessary.

Due to the rapid growth of NYUWS, NYULH and Regeneron the trainee(s) will have opportunities to participate in the development and opening of new animal facilities, and/or the expansion of existing facilities. Beyond this practical experience, organized time will be provided to the trainee to develop an understanding of animal resource facility operations and management. Postdoctoral fellows will be introduced to the day-to-day husbandry needs by participating in all aspects of daily operations. This will include time spent in cage wash facilities, performing daily animal care staff tasks and working closely with facility managers. Facility operations training will be supplemented by didactic lessons and familiarization with appropriate facility SOPs. Postdocs will be called upon to create, edit or revise SOPs as required during rotations. Trainee(s) will also be exposed to cost accounting principles, budgeting and other pertinent financial concepts. Opportunities for personnel oversight will be provided to help trainees learn basic management skills.

Additional training in laboratory animal pathology will be incorporated while on rotation at Regeneron. Training will occur under the direct supervision of Board Certified Pathologists or qualified veterinarians. Laboratory animal pathology training will allow each trainee to develop an understanding of, and a capability to perform anatomic pathology techniques and to develop skill sets needed to allow for accurate interpretation of findings. The pathophysiology of disease will be discussed both during pathology rotations and during the weekly clinical and pathology rounds. 

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Regulatory Training

Postdoctoral fellows will have opportunities to observe or participate in IACUC meetings at each training location. When fellows are appointed as alternate or active voting members to one of the IACUC committees it is expected that all efforts will be made to attend and participate. As part of IACUC training each trainee will be expected to read their assigned IACUC protocols prior to each scheduled meeting and to critically discuss assigned protocols with veterinary mentors, or review the IACUC protocols as an alternate voting member within the assigned time frame. Fellows may be asked to present IACUC protocols designated for full committee review at scheduled IACUC meetings, participate in semiannual inspections or may be requested to attend regulatory or compliance meetings. As part of regulatory training, program participants will be expected to accompany regulatory personnel (USDA, NYS DOH) and AAALAC site visitors when inspections or site visits occur.  


Research

Postdoctoral fellows will be assigned a period of 12 months to design and implement a mentored research project. Fellows will be expected to perform the majority of research tasks on their own to develop research technique proficiency. Trainees must provide a project outline in grant form including project proposal and budget, regardless if submitting for an actual grant, and formally present their proposed project in a seminar format to veterinary faculty for approval. All projects must be hypothesis driven and are expected to culminate in a first author publication in an appropriate peer-reviewed journal. When possible manuscript preparation will be combined with a formal academic writing course offered through NYU Langone Health.

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