Gut Microbiome in Food Protein-Induced Enterocolitis Syndrome: An Observational Study
Food protein-induced enterocolitis syndrome (FPIES) is a non IgE-mediated food allergy that manifests with predominantly gastrointestinal symptoms and usually starts in the first year of life. There is no diagnostic biomarker and no treatment for FPIES beyond food avoidance, reflecting poorly understood pathophysiology. This is a prospective observational study, which will compare fecal microbiota, fecal short chain fatty acids and metabolomics between infants and toddlers with FPIES and control infants and toddlers without food allergy, 0-36 months old. It will also compare mucosal immunity via epigenetic markers in blood in infants and toddlers with FPIES, and those with IgE-mediated food allergy. Stool samples will be collected from 150 infants with FPIES and 106 sex and age matched control infants and toddlers from birth through 36 months. Optional blood samples will be collected only from infants and toddlers with FPIES and toddlers with IgE-mediated food allergies (0-36 months old). A questionnaire will be used to obtain information detailing the child’s feeding, medical, birth, and family history.
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