Department of Anesthesiology, Perioperative Care & Pain Medicine Research
NYU Langone’s Department of Anesthesiology, Perioperative Care, and Pain Medicine is dedicated to scientific investigation that advances the care of our patients in the operating room, as well as in the perioperative and critical care settings.
Our researchers collaborate with scientists from NYU Langone’s Interdisciplinary Pain Research Program, Neuroscience Institute, and Department of Neuroscience and Physiology to bring research findings from bench to bedside.
Our department’s basic science researchers, including Bernardo Rudy, MD, PhD, and Jing Wang, MD, PhD, conduct research that enables anesthesiologists to have a better understanding of the mechanisms of the brain, including regulation of acute and chronic pain. This knowledge ultimately improves the safety and efficacy of anesthesia.
Wenbiao Gan, PhD, conducts research on learning and memory, sleep, synaptic plasticity and stability, microglia, and Alzheimer’s disease. Studying the underlying pathophysiology of conditions affecting patients who may need perioperative or critical care anesthesiology can ultimately help to improve their care.
Michael Schlame, MD, is conducting research on the role of mitochondria in the rare genetic condition Barth syndrome, which can lead to heart failure and severe infections requiring critical care anesthesiology.
Mitochondria are membrane-rich organelles that are essential to eukaryotic life. Detailed insight has emerged into the assembly and dynamics of mitochondrial membrane proteins, but a fundamental gap remains in understanding mitochondrial lipids.
Barth syndrome is a disorder of the mitochondrial lipid metabolism, in particular the metabolism of the mitochondria-specific phospholipid cardiolipin. The syndrome is caused by mutations in tafazzin, an enzyme that catalyzes the fatty acid exchange reaction by which the characteristic molecular composition of cardiolipin is created. This reaction is also referred to as cardiolipin remodeling.
The objective of Dr. Schlame’s current research is to identify the mechanism and function of cardiolipin remodeling to better understand the function of cardiolipin in mitochondria and to unravel the molecular pathophysiology of Barth syndrome.
Our researchers are also conducting the following clinical studies to better understand pain management in patients and to improve quality of life and monitor outcomes throughout their perioperative care.
Critical Care Anesthesiology
Sepsis Pre-Alert Monitoring Intervention: Study to Investigate Targeted Enhanced Monitoring for Sepsis
Investigators: Mark E. Nunnally, MD, and Germaine Cuff, PhD
Use of EEG to Identify Sleep Deficits Associated with Postoperative Pain: Retrospective Study
Investigator: Jing Wang, MD, PhD
Interlaminar Particulate Steroid Versus Transforaminal Steroid Injection in Low Back Pain Patients
Investigator: Kristoffer Padjen, MD, PhD
A Pilot Proof of Concept, Single-Center Study of the Effects of Telephone-Delivered Mindfulness-Based Cognitive Therapy (MBCT-T) on Preoperative Pain Catastrophizing and Pain Outcomes After Spine Surgery
Investigator: Lisa V. Doan, MD
Retrospective Study Examining Perioperative Opioid and Other Analgesic Use and Outcomes
Investigator: Lisa V. Doan, MD
For more information about our basic and clinical research programs, please contact Germaine Cuff, PhD, director of quality assurance and outcomes, at email@example.com.