Adult Cardiac Surgery Research
The Division of Adult Cardiac Surgery at NYU Langone is at the forefront of research to improve cardiac devices and pioneer new surgical and transcatheter procedures. We lead and participate in clinical research trials that help uncover new treatment options and improve patient outcomes.
Our researchers investigate improvements in valve technology and surgery, studying the safety of transcatheter aortic valve replacement (TAVR), transcatheter mitral valve replacement, valve performance, and patient outcomes over the long term.
Mathew R. Williams, MD, and his colleagues study ways to diagnose aortic stenosis earlier, in order to identify patients who would benefit from TAVR. They test new TAVR and transcatheter mitral valve replacement systems, looking to improve outcomes. This includes assessing the safety and performance of valve replacements in patients with severe aortic stenosis who are not candidates for or who have a high risk of needing open-heart valve surgery, as well as those with severe symptomatic mitral regurgitation.
Dr. Williams and his team study the use of transfemoral TAVR in heart failure patients. In addition, they use a transesophageal echocardiography–angiography fusion software prototype to visualize anatomic landmarks during structural heart disease procedures.
Eugene A. Grossi, MD, is the principal investigator on a study of mitral leaflet and chordal tissue in patients with degenerative mitral regurgitation to develop patient-specific repair strategies. He collaborates with engineering colleagues to develop simulation models to better teach the next generation of surgeons how to repair mitral valves. He works with Didier F. Loulmet, MD, to study and quantify the outcomes of totally endoscopic mitral valve repair, documenting markedly shorter hospital stays and enhanced patient recovery in more than 500 patients with minimally invasive mitral valve repairs.
For patients with heart failure, Nader Moazami, MD, and his colleagues are working on new ventricular assist device platforms that improve the interaction between biology and mechanics. The goal is to identify the deficiencies in available devices and create improved systems that function better with human physiology. Dr. Moazami and his team seek a better understanding of the role of pulsatility in microcirculation by studying patients with continuous flow left ventricular assist devices to determine the impact of flow and pressure on human physiology. They are developing isolated perfusion models for improving organ preservation in transplantation.