MS in Clinical Investigation

Clinical & Translational Science Institute Degree Programs MS in Clinical Investigation
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MS in Clinical Investigation

The MS in Clinical Investigation (MSCI) at NYU School of Medicine prepares investigators with the knowledge, skills, and experience necessary to succeed in academic careers in clinical research.

This two-year program is open to clinical and translational investigators with a clinical doctorate degree. You must be actively involved in clinical research at NYU Langone Health or an NYC Health + Hospitals affiliate, be board eligible or certified in a clinical specialty, and currently licensed to practice medicine in New York State.

MSCI Concentrations

Candidates in the MSCI program may pursue one of several concentrations that provide focused training tailored to specific interests within the broad field of clinical and translational research.

At NYU Langone’s Clinical and Translational Science Institute, you can enroll in a concentration in translational research or in health innovations and therapeutics. A third concentration in comparative effectiveness research is offered through the Department of Population Health.

Translational Research

With a concentration in translational research, you gain a deep understanding of research methodologies through didactic learning and supervised research and also have opportunities to put your new skills into clinical practice. Throughout the program, you receive mentoring from a primary investigator and program faculty to help you navigate the early stages of your career.

You are required to complete a mentored translational research project and meet specific translational research program milestones to graduate.

MSCI in Translational Research Curriculum

 Year Summer Fall Spring
1 Clinical Research Methods Introduction to Biostatistics Biomolecular Medicine
  Ethical Conduct of Research Advanced Epidemiology OR Drug Development in a New Era Clinical Trials Design
    Integrative Seminar I Integrative Seminar II
    Mentored Research Advanced Biostatistics (Elective)
      Health Services Research Methods (Elective)
      Mentored Research
2 Mentored Research (not for credit) Medical Informatics Integrative Seminar IV
    Grant Writing Mentored Research
    Integrative Seminar III  
    Mentored Research  

Health Innovations and Therapeutics

If you pursue a concentration in health innovations and therapeutics, you take the same core curriculum as candidates on the translational research track and three additional courses geared toward drug and device development.

These include two courses on drug development at the preclinical and clinical levels and a business course that focuses on bringing innovations to the marketplace.

Throughout the program, you receive mentoring from distinguished faculty and a primary investigator and conduct independent research—ideally in the form of drug or device testing or development.

You are required to meet specific health innovations and therapeutics program milestones in order to graduate.

MSCI in Health Innovations and Therapeutics Curriculum

Year Summer Fall Spring
1 Clinical Research Methods Introduction to Biostatistics or Drug Development in a New Era Biomolecular Medicine (Selective)
  Ethical Conduct of Research Advanced Epidemiology (Elective) Clinical Trials Design
    Integrative Seminar I Biotechnology Industry, Structure, and Strategy
    Mentored Research Molecular Signaling and Drug Development
      Integrative Seminar II
      Mentored Research
2 Mentored Research (not for credit) Medical Informatics Health Services Research Methods (Elective)
    Grant Writing Advanced Biostatistics (Elective)
    Integrative Seminar III Trending Topics Elective
    Mentored Research Integrative Seminar IV
    Mentored Research Mentored Research

How to Apply to the MSCI Program

Applicants to the MSCI program who wish to specialize in translational research or health innovations and therapeutics apply to NYU Langone’s Clinical and Translational Science Institute. Applicants must complete the appropriate concentration-specific online application and upload the following documents:

  • your CV
  • a personal statement that addresses your career goals and plans beyond the master’s program
  • a research plan
  • three letters of recommendation
  • a recent photograph

Access the online applications for either concentration—translational research or health innovation and therapeutics application. An MSCI application checklist is available to help you organize required materials. Incomplete applications are not accepted. For more information, contact us at msciprogram@nyumc.org.

Those who wish to apply to the concentration in comparative effectiveness research do so through the Department of Population Health.

MSCI Course Descriptions

Students must complete 33 credits to complete the translational research concentration and 35 credits for health innovations and therapeutics concentration from the courses below.

Clinical Research Methods

This course provides an in-depth introduction to principles of clinical research, the use of reading, protocol development, and problem sets. It features seminars and brief mini-lectures to review these concepts, followed by in-depth discussions built on assigned reading and exercises.

Each candidate develops a research protocol following an iterative process in which practical feedback is given in individual and small-group protocol review sessions. By the end of the course, each student presents their research protocol, which describes in detail the aims, background, and study plan for an investigation to address a question formulated by the student.

Ethical Conduct of Research

This required course provides important insights into general scientific ethics, regulatory responsibilities, and ethical considerations regarding human subjects, research reporting, and intellectual property.

Introduction to Biostatistics

This practical and interactive course introduces students to probability and statistical methods used in analysis and interpretation of experimental and epidemiological data.

Advanced Epidemiology

This course is designed to introduce students in all fields to the basic principles and methods of public health epidemiology. Topics covered include measures of disease frequency and risk; epidemiological study designs, both experimental and nonexperimental; understanding bias; and measures of effect and association. Students also develop the skills to read, interpret, and evaluate health information from published epidemiological studies and mass media sources.

Drug Development in a New Era

This course provides an overview of new drug development to entry-level professionals in the medical sciences. Seminars include a combination of lectures and discussions. Invited speakers from the academic and private sectors offer an array of viewpoints. By the end of the course, participants have a store of new knowledge and skills, including knowledge of the vocabulary and principles of new drug development; ability to assess the nonclinical background of a drug; practical skills in interacting with regulatory agencies during the course of new drug development; and ability to discuss the financial and marketing issues pertaining to new drugs.

Integrative Seminar in Translational Research

This seminar provides a forum to come together in small groups, share work in progress, and receive feedback and guidance on ongoing research from peers and faculty seminar leaders.

Scheduled activities include weekly research and journal club presentations, interspersed with career development activities. Emphasis is on group discussion, collaborative and team-based approaches to problem solving, and methodological and scientific study design and execution.

Integrative Seminar in Health Innovation and Therapeutics

This seminar provides a forum to come together in small groups, share work in progress, and receive feedback and guidance on ongoing research from peers and faculty seminar leaders.

Scheduled activities include weekly research and journal club presentations interspersed with career development activities. Emphasis is on group discussion, collaborative and team-based approaches to problem solving, and methodological and scientific study design and execution.

Advanced Biostatistics

Students in this course gain expertise in performing and interpreting multiple regression analysis and applying these methods to their own research data. The course focuses on analytic methods, assumptions, diagnostics, modeling options, tests of significance, and interpretation in multiple linear and logistic regression analysis.

Biomolecular Medicine

This course familiarizes students with current biomolecular technologies useful for answering scientific questions. Students are introduced to faculty members who can assist them with advancing a research project. For those who do not require biomolecular technologies for their research, this course improves their ability to understand background science and literature pertinent to their scientific interests and prepares them for collaboration with basic scientists in the future.

Clinical Trial Design

This course provides students with an overview of clinical trial design using examples that showcase a range of different approaches. Students learn to frame a focused clinical trial question; specify patient eligibility criteria, distinguishing between inclusion and exclusion criteria; describe the administrative structure of a clinical trial; determine sample size parameters; explain a statistical analysis plan; distinguish between different forms of clinical benefit; and interpret clinical trial data from published articles.

Health Services Research Methods

This research methods course reviews core methodological approaches and general principles of population health research. Lectures are combined with practical discussions applying course principles to the students’ research projects.

Biotechnology Industry, Structure, and Strategy

Biotechnology started as a science, referring to the use of living cells as factories to produce proteins through the manipulation of genes. Today, biotechnology refers to an industry, with the top companies in the sector exceeding some of the major pharmaceutical companies in market capitalization.

No longer are biotechnology companies confined to using recombinant DNA technology alone. The moniker is assigned today to any small company engaged in any life sciences–related research directed toward developing a commercial product, using any scientific means.

Belonging to the sector usually also implies a culture—small, nimble, and visionary; practical and cash constrained but willing to risk it all. Although some of these characteristics are more idealized than realized, it is certainly the case that even though the key factors for success in a development-stage company include the same scientific, analytic, and managerial talents that exist in “big pharma,” the context is different. Biotechnology companies must incorporate some additional skills to ensure survival and nontraditional systems to support success.

Medical Informatics

This course introduces trainees to medical informatics, the interdisciplinary science of information management in medicine. Focusing on areas relevant to clinical research, students learn innovative methods to capture, store, and retrieve clinical and population-level data, as well as ways in which information systems can support research intervention.

Grant Writing

This course provides instruction and skill-building opportunities related to applying for federal and other types of grants. The course reviews research design issues and provides instruction on how to develop and and describe a research abstract, specific aims, background, preliminary studies, methods, human subject protection issues, and budgets and budget justification. National Institutes of Health (NIH) grant forms and regulations are also reviewed. In addition to interactive didactic sessions, students are given the opportunity to complete applications using a standard NIH format. Subsequent didactic sessions address peer review, and students act as peer reviewers for submitted applications.

Trending Topics

This course varies from semester to semester depending on student and faculty interests. However, the focus is typically on important issues in the area of health innovations and therapeutics. Topics may include new drugs, new health devices, revolutionary discoveries, journal reviews, and changes in intellectual property law.