Karan Singh, PhD, Postdoctoral Fellow

Karan Singh, PhD I obtained my Ph.D. from the Indian Institute of Science Education and Research Mohali, India, in the Evolutionary Genetics and Microbiology.  During my graduate study, I explored the genetic basis of thermal adaptation and evolutionary ecology immunity. I also worked on the host-parasite interactions and have isolated novel bacterial pathogen from wild flies.

After finishing my PhD, I joined the Perelman School of Medicine-University of Pennsylvania as a postdoctoral fellow where I was involved in investigating the role of γ-herpes virus latent proteins in the chromosome instability which leads to cell proliferation. I also investigated the epigenetic regulation of the stem cell factors which leads to cell proliferation and metastasis in B-cell lines as well as in endothelial cell lines.

I am a postdoctoral fellow in the Diabetes Research Program. I am interested in the molecular and epigenetic mechanisms by which the receptor for advance glycation end-products (RAGE) and Diaph1 pathway modifies the properties of macrophages, as relevant to diet induced obesity and diabetes.

 

Publications
1. Singh K, Zulkifli M and Prasad NG (2016) Identification and characterization of novel natural pathogen of Drosophila melanogaster isolated from wild captured Drosophila spp. Microbes and Infection. 18: 813-821.

2. Singh K, Samant M, Tom M and Prasad NG (2016) Evolution of pre- and post-copulatory traits in male Drosophila melanogaster as correlated response to selection for increased resistant to cold stress. PLoS One 11: e0153629.

3. Singh K and Prasad NG (2016). Evolution of pre- and post-copulatory traits in female D. melanogaster as correlated response to selection for increased resistant to cold stress. Journal of Insect Physiology 91: 26-33.

4. Singh K, Kochar E and Prasad NG (2015). Egg viability, male mating ability and mating frequency evolve in populations of Drosophila melanogaster selected for resistance to cold shock. PloS One 10: e0129992.