Orthostatic Intolerance

Status: Recruiting

Phenotype of Primary Autonomic Disorders: Primary autonomic disorders are a group of diseases that usually begin in adulthood with the inability to stand because of dizziness, lightheadedness, and fainting. Symptoms are the result of a dysfunction in the autonomic nerves that regulate blood pressure and heart rate. Studying primary autonomic disorders poses special research challenges, primarily because these disorders are rare and affect only a small number of patients. The Autonomic Disorders Consortium was established with the objective of combining the medical expertise of leading autonomic sites within the United States to develop a clearer understanding of primary autonomic disorders, with the hope of developing new treatments and providing better guidance and recommendations for patient care to the medical community. The first specific aim of this project is to create a database of patients with primary autonomic disorders that will include all of their clinical features. We will use a comprehensive, integrated approach that will combine standardized clinical, physiological, and biochemical studies to characterize the features of rare autonomic disorders, including disorders that are already known and others still undiscovered. This database will also allow us to identify adequate candidates for the therapeutic trials and natural history study (Specific Aim 2 of this project) of the Rare Diseases Clinical Research Network (RDCRN) Autonomic Disorders Consortium (ADC). http://clinicaltrials.gov/ct2/show/NCT01799915

Eligibility: The study is open to people with orthostatic intolerance (dizziness/light-headedness on standing) above the age of 18 years.

IRB#: 08-1408

Sponsor: National Institutes for Health