Genome Technology Center Featured Publications

Genome Technology Center Genome Technology Center Featured Publications
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Genome Technology Center Featured Publications

Our staff members and collaborators frequently publish their research in leading peer-reviewed publications. Here is a selection of their recent accomplishments.

Mitchell LA, Wang A, Stracquadanio G, Kuang Z, Wang X, Yang K, et al. Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond. Science. 2017;355(6329).

Bayin NS, Frenster JD, Kane JR, Rubenstein J, Modrek AS, Baitalmal R, et al. GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth. Oncogenesis. 2016;5(10):e263.

Malaspina D, Kranz TM, Heguy A, Harroch S, Mazgaj R, Rothman K, et al. Prefrontal neuronal integrity predicts symptoms and cognition in schizophrenia and is sensitive to genetic heterogeneity. Schizophr Res. 2016;172(1–3):94–100.

Culver BP, DeClercq J, Dolgalev I, Yu MS, Ma B, Heguy A, et al. Huntington's disease protein huntingtin associates with its own mRNA. J Huntingtons Dis. 2016;5(1):39–51.

Diamond EL, Durham BH, Haroche J, Yao Z, Ma J, Parikh SA, et al. Diverse and targetable kinase alterations drive histiocytic neoplasms. Cancer Discov. 2016;6(2):154–65.

Schafer MJ, Dolgalev I, Alldred MJ, Heguy A, Ginsberg SD. Calorie restriction suppresses age-dependent hippocampal transcriptional signatures. PLoS One. 2015;10(7):e0133923.

Montenegro D, Kalpana K, Chrissian C, Sharma A, Takaoka A, Iacovidou M, et al. Uncovering potential 'herbal probiotics' in Juzen-taiho-to through the study of associated bacterial populations. Bioorg Medical Chem Lett. 2015;25(3):466-9.

Selected Publications

Cardiac arrhythmia and neuroexcitability gene variants in resected brain tissue from patients with sudden unexpected death in epilepsy (SUDEP)

Friedman, Daniel; Kannan, Kasthuri; Faustin, Arline; Shroff, Seema; Thomas, Cheddhi; Heguy, Adriana; Serrano, Jonathan; Snuderl, Matija; Devinsky, Orrin

NPJ genomic medicine. 2018 Mar 27; 3:9-9

Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

Danussi, Carla; Bose, Promita; Parthasarathy, Prasanna T; Silberman, Pedro C; Van Arnam, John S; Vitucci, Mark; Tang, Oliver Y; Heguy, Adriana; Wang, Yuxiang; Chan, Timothy A; Riggins, Gregory J; Sulman, Erik P; Lang, Frederick; Creighton, Chad J; Deneen, Benjamin; Miller, C Ryan; Picketts, David J; Kannan, Kasthuri; Huse, Jason T

Nature communications. 2018 Mar 13; 9:1057-1057

The Ancient Origins of Neural Substrates for Land Walking

Jung, Heekyung; Baek, Myungin; D'Elia, Kristen P; Boisvert, Catherine; Currie, Peter D; Tay, Boon-Hui; Venkatesh, Byrappa; Brown, Stuart M; Heguy, Adriana; Schoppik, David; Dasen, Jeremy S

Cell. 2018 Feb 08; 172:667-682.e15

Single-Cell RNA Sequencing of Glioblastoma Cells

Sen, Rajeev; Dolgalev, Igor; Bayin, N Sumru; Heguy, Adriana; Tsirigos, Aris; Placantonakis, Dimitris G

Methods in molecular biology. 2018 02; 1741:151-170

Staphylococcus aureus Responds to the Central Metabolite Pyruvate To Regulate Virulence

Harper, Lamia; Balasubramanian, Divya; Ohneck, Elizabeth A; Sause, William E; Chapman, Jessica; Mejia-Sosa, Bryan; Lhakhang, Tenzin; Heguy, Adriana; Tsirigos, Aristotelis; Ueberheide, Beatrix; Boyd, Jeffrey M; Lun, Desmond S; Torres, Victor J

MBio. 2018 Jan 23; 9:

Nascent Induced Pluripotent Stem Cells Efficiently Generate Entirely iPSC-Derived Mice while Expressing Differentiation-Associated Genes

Amlani, Bhishma; Liu, Yiyuan; Chen, Taotao; Ee, Ly-Sha; Lopez, Peter; Heguy, Adriana; Apostolou, Effie; Kim, Sang Yong; Stadtfeld, Matthias

Cell reports. 2018 Jan 23; 22:876-884

Gut Microbiota Perturbations in Reactive Arthritis and Post-Infectious Spondyloarthritis

Manasson, Julia; Shen, Nan; Garcia Ferrer, Helga R; Ubeda, Carles; Iraheta, Isa; Heguy, Adriana; Von Feldt, Joan M; Espinoza, Luis R; Kutzbach, Abraham Garcia; Segal, Leopoldo N; Ogdie, Alexis; Clemente, Jose C; Scher, Jose U

Arthritis & rheumatology. 2018 Jan 3; 70:242-254

Role of dysregulated cytokine signaling and bacterial triggers in the pathogenesis of Cutaneous T Cell Lymphoma

Fanok, Melania H; Sun, Amy; Fogli, Laura K; Narendran, Vijay; Eckstein, Miriam; Kannan, Kasthuri; Dolgalev, Igor; Lazaris, Charalampos; Heguy, Adriana; Laird, Mary E; Sundrud, Mark S; Liu, Cynthia; Kutok, Jeff; Lacruz, Rodrigo S; Latkowski, Jo-Ann; Aifantis, Iannis; Odum, Niels; Hymes, Kenneth B; Goel, Swati; Koralov, Sergei B

Journal of investigative dermatology. 2017 Nov 08;