The Parkinson s Progression Markers Initiative (PPMI) 2.0 Clinical - Establishing a Deeply Phenotyped PD Cohort
The purpose of this study is to continue to obtain information from people with and without Parkinson disease (PD) so that researchers may better understand how Parkinson disease progresses, in order to inform better treatments. The information collected in this study is for research and not for clinical care. This study is an expansion of the PPMI study that has been ongoing for nearly ten years. The information this study will collect clinical information, brain imaging scans, samples of blood, urine, cerebral spinal fluid, information from digital applications and self-reported information from questionnaires completed online. Participants may be asked if they are interested in enrolling in a brain and tissue bank.
The PROGRESS Trial: A Prospective Randomized Controlled Trial to Assess the Management of Moderate Aortic Stenosis by Clinical Surveillance or Transcatheter Aortic Valve Replacement
This study is being done to see if the SAPIEN 3™ and SAPIEN 3 Ultra™ Transcatheter Heart Valve is beneficial for patients with moderate, calcific aortic stenosis. The SAPIEN 3™ and SAPIEN 3 Ultra™ Transcatheter Heart Valve are not approved by the Food and Drug Administration (FDA) for the treatment of moderate, calcific aortic stenosis and is considered experimental in this research.
THE PROSPECTIVE NATURAL HISTORY OF FAMILIAL DYSAUTONOMIA
To create a database of clinical information collected from you/your child’s medical chart on a yearly basis from patients with familial dysautonomia (FD). This study is “observational” and “non-interventional”, meaning you/your child will not receive any treatments, drugs, or tests that are not part of your/your child’s standard clinical care.
The Psorcast Study: A Validation Study of a Smartphone Sensor-Based Patient-Driven Detection of Psoriatic Disease
Smartphone-based and physician-assessed measures will be collected at baseline and 12 weeks after initiating a new therapy for psoriatic disease. Weekly digital assessments will also be performed.
The Role of Exercise in the Consolidation of Fear Extinction Learning in Adults with High Anxiety Sensitivity
The purpose of this study is to investigate differences in extinction learning (measured by skin conductance [sweating] and heart rate) in adults with high anxiety sensitivity and anxiety disorders following exercise or sitting. If you are eligible for this study after 1 screening visit, you will complete a 3-day emotional learning experiment. You will be randomly assigned (like the flip of a coin) to either exercise at moderate intensity or sit for 20 minutes after the emotional learning experiment on Day 2. This research study involves 4 in-person visits total (the 3 experimental visits and 1 screening visit beforehand). This is not a treatment study.
The Role of Residual Hearing in Cochlear Implant Outcomes
The purpose of the study is to learn more about how cochlear implants benefit patients who can hear some things with hearing aids or without their implant. This observational study will examine residual hearing in cochlear implant patients to determine how it affects performance with the device. Three groups will participate: normal hearing listeners, hearing impaired individuals without a cochlear implant and hearing impaired individuals with a cochlear implant. Behavioral tests of residual hearing will take place before and after implantation. Performance on these tests will be compared to normal hearing controls. The primary objective is to determine how residual hearing affects cochlear implant outcomes. Secondary objectives include determining the contribution of residual hearing to electro-acoustic hearing and designing new assessments for residual hearing.
THE ROLE OF THE MICROBIOME IN MONOZYGOTIC TWINS WITH PSORIASIS AND PSORIATIC ARTHRITIS
Psoriasis is a chronic immune-mediated skin condition that often presents with plaques on the skin. Psoriatic arthritis is an inflammatory arthritis associated with psoriasis. Approximately a third of patients who have psoriasis later develop psoriatic arthritis. The purpose of this study is to explore why people get psoriatic disease and why some progress from having disease of the skin (psoriasis) to having disease in the joints (psoriatic arthritis). For this study, the researchers are particularly interested in the role that the human microbiome plays in developing psoriasis and psoriatic arthritis. The study will try to answer this question by collecting blood, stool, skin swab, and optional urine and skin biopsy samples, in addition to a clinical questionnaire. The samples collected will allow the researchers to study the causes of psoriatic disease, why it gets worse in certain individuals, and what protects other individuals from getting the disease or from progressing.
The Story of Sala Institute | NYU Langone Health
Sala Institute for Child and Family Centered Care was founded in tribute to Sala Bierman Elbaum.
The use of cannabidiol (CBD) in pain reduction for knee osteoarthritis. A Double-Blind Randomized Control Study
The purpose of this study is to see if cannabidiol (CBD) orally dissolving tablets (ODTs) can lessen pain needed in people with knee osteoarthritis. CBD comes from the cannabis plant and is non-psychoactive (i.e. does not produce a ‘high’ or altered mental state) as compared to tetrahydrocannabinol (THC), another compound found in cannabis. Researchers are studying different forms of CBD for potential use in treating pain, inflammation, and illnesses. One form of CBD is Food and Drug Administration (FDA) approved for treating severe types of epilepsy that affect children. In this study, the CBD ODT is considered an investigational drug because it is not Food and Drug Administration (FDA) approved for osteoarthritis.
Therapeutic Injections for Bursitis & Tendinitis | NYU Langone Health
NYU Langone doctors may recommend injections of corticosteroids, platelet-rich plasma, or stem cells to relieve bursitis or tendinitis symptoms.