deciphEHR is a genomic medicine program at NYU Langone Health to make annotated genomes of NYU Langone patients together with their electronic health record (EHR) available to the NYU Langone community. The participants in this resource were consented using NYU Langone’s Universal Consent (UC) protocol. The project is currently in an infrastructure building and research phase dedicated to answering basic and translational science questions. We expect to keep adding participants to deciphEHR, increasing the types of biological samples collected, consenting future participants for return of results, and in the future using the lessons we learn for personalized clinical care at our institution.

The deciphEHR pilot phase was launched in 2024 and, as of today, has low-coverage sequenced over 11,000 genomes from a total of currently 58,000 NYU Langone patients with Universal Consent. These data have been integrated with phenotypes from the Epic electronic health records. Our next goal is to sequence up to 100,000 genomes by the end of the pilot phase. These genome and phenome data are accessible to all NYU Langone investigators upon submitting an online application.