Center for Cognitive Neurology Research Studies | NYU Langone Health

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Center for Cognitive Neurology Research Center for Cognitive Neurology Research Studies

Center for Cognitive Neurology Research Studies

Research studies and clinical trials are the force behind the prevention, treatment, and possible cure of any disease. Members of NYU Langone’s Center for Cognitive Neurology are currently participating in the following research studies.

Memory Screening and Longitudinal Studies of Aging

The following studies are being conducted by members from the Department of Neurology and the Department of Psychiatry.

Longitudinal Study of Normal Aging, Mild Cognitive Impairment (MCI), and Alzheimer’s Disease

The goal of this study is to improve early diagnosis and better understand the clinical course and causes of age-related cognitive decline and Alzheimer’s disease. Participants receive a comprehensive diagnostic evaluation and are re-evaluated every year. For information, contact Ashley Clayton, MA, program manager, at 212-263-3257 or email

Principal investigator: Thomas M. Wisniewski, MD

Orexin (Hypocretin) and Tau Pathology in Cognitively Normal Elderly: A New Prevention Strategy for Alzheimer’s Disease (TONE Study)

Our preliminary results suggest that tau pathological changes that occur in the brainstem years before the onset of clinical symptoms disrupt the orexinergic system, resulting in sleep disruption, changes in core body temperature (CBT), and further Alzheimer’s disease–type neurodegeneration in a feed-forward cycle. We will test this hypothesis in up to 19 cognitively normal older adults by performing a full clinical evaluation, a tau PET/MRI scan, 2 nights of nocturnal polysomnography (during which we will measure CBT), and a lumbar puncture to obtain cerebrospinal fluid. We are currently enrolling male and female participants with normal cognition between the ages of 55 and 75 whose total sleep time is between 6 and 8 hours and who do not have moderate to severe obstructive sleep apnea. For information, contact Margo Miller at 212-263-7563 or

Principal investigator: Ricardo M. Osorio Suarez, MD

Sleep, Aging, and Risk for Alzheimer’s Disease (SARA 2.0 Study)

We are currently undertaking a 24- to 30-month longitudinal study of 124 subjects in order to analyze the relationship between 2 common sleep disorders and Alzheimer’s disease risk. Age-related sleep changes and common sleep disorders like obstructive sleep apnea may increase amyloid burden and represent risk factors for cognitive decline in the elderly. Participants must be able to schedule an initial visit with us for a physical exam, cognitive testing, sleep interview, EKG, clinical labs, and blood sample. We will also conduct a 2-night polysomnography and amyloid deposition using 11C-PiB PET/MRI scanning both at baseline and at a 24-month follow-up.

We are currently enrolling healthy male and female participants in the New York City area between the ages of 60 and 75 with normal cognition. We can accept approximately 50 percent of participants with mild to moderate obstructive sleep apnea. Participants receive results of all testing and are compensated for their time. For information, contact Margo Miller at 212-263-7563 or

Principal investigator: Ricardo M. Osorio Suarez, MD

Join Our Research Registry

Many clinical research studies take time to begin or are delayed because few people sign up. Help us change this and become part of our research registry. When you join the registry, we send you opportunities to take part in our research studies, as well as news and research updates. Joining the registry is easy and can be done by answering a few questions. We keep your information private and safe. To join, please fill out our research registry form.