NYU Langone’s Comprehensive Epilepsy Center has a robust clinical trials program, allowing pediatric and adult patients the possibility to access new anti-seizure medications or novel treatments before they come to market.

It is led by Jacqueline A. French, MD, and Blanca Vazquez, MD, clinical trials directors, and Claude Steriade, MD, clinical trials co-director.

Patients at the center have taken part in more than 100 multicenter studies for treating both focal and generalized epilepsy.

Patients are screened for eligibility by our study team and doctors. If eligible, patients can be enrolled in a clinical trial and receive experimental treatment and regular evaluation by the research staff to assess how safe and effective the drug or treatment under study is.

Contact Us

If you have uncontrolled seizures and are interested in participating in a clinical trial, please speak to your doctor, call us at 646-558-0839 or email us at CECResearchStudyInfo@NYULangone.org to determine your eligibility for any of our ongoing trials.

Active Clinical Trials

Our investigators lead a range of clinical trials to understand the causes and the impact of epilepsy in patients, and to identify new or more effective treatment options.

A complete list of our studies can be found here.

Epilepsy

A Randomized Double-Blind Placebo-Controlled Multicenter Study to Evaluate the Safety Tolerability and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Epilepsy
Principal investigator: Claude Steriade, MD

A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Basket Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Satralizumab in Patients with Anti0-N-Methyl-D-Aspartic Acid Receptor (NMDAR) or Anti-Leucine-Rich Glioma-Inactivated 1 (LGI1) Encephalitis
Principal investigator: Claude Steriade, MD

A Phase 2/3 Multicenter Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy, Safety and Tolerability of BHV-7000 in Subjects with Refractory Focal Onset Epilepsy- RISE 3
Principal Investigator: Claude Steriade, MD

A Double-Blind, Randomized, Multicenter, Trial Evaluating the Efficacy and Safety of PRAX-628 in Adults with Focal Seizures (POWER 1)
Principal Investigator: Claude Steriade, MD

A Double-Blind Outpatient Study to Investigate the Efficacy and Safety of a Single Administration of Staccato Alprazolam in Study Participants ≥12 Years of Age with Stereotypical Prolonged Seizures
Principal Investigator: Claude Steriade, MD

An Open-Label Study to Investigate the Safety and Pharmacokinetics of Single Ascending Doses of Antisense Oligonucleotide STK-001 in Children and Adolescents with Dravet Syndrome
Principal investigator: Orrin Devinsky, MD

A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults with Dravet
Syndrome
Principal Investigator: Dana Price, MD

Sudden Death

Multicenter Study of Epilepsy Surgery Long-Term Outcomes Mortality
Principal investigator: Orrin Devinsky, MD

Risk Factors for Sudden Unexplained Death in Epilepsy (SUDEP)
Principal investigator: Orrin Devinsky, MD

Genetics and Precision Therapies

Study of Inherited Monogenic Disorders in Patient and Tissue-Specific Cells
Principal investigator: Orrin Devinsky, MD

Human Epilepsy Project

Human Epilepsy Project 3: Newly Diagnosed Idiopathic Generalized Epilepsy
Principal investigator: Christopher Elder, MD

Neurotechnology and Brain Stimulation

Mechanisms and Enhancement of Learning During Sleep
Principal investigator: Anli A. Liu, MD

Neuroinflammation and Neurodegeneration

New-Onset Refractory Status Epilepticus (NORSE)
Principal investigator: Claude Steriade, MD

Gut Microbiome Alterations as a Mechanism of Immune Dysregulation in New-Onset Refractory Status Epilepticus (NORSE)
Principal investigator: Claude Steriade, MD

Prevalence and Predictors of Antineuronal Antibody Positivity in Focal Epilepsy
Principal investigator: Claude Steriade, MD

TSPO-Ligand PET Imaging in Autoimmune Epilepsy
Principal investigator: Claude Steriade, MD

Study of Inherited Monogenic Disorders in Patient and Tissue-Specific Cells
Principal investigator: Chengzu Long, PhD

Human Cognition and Neuroscience

Behavioral and Neural Correlates of Speech Production During Delayed Auditory Feedback in Subthalamic Nucleus: A Prospective Study in Parkinson’s Subjects Undergoing Deep Brain Stimulation Surgery
Principal investigator: Adeen Flinker, PhD

Neuroimaging, Human Cognition, and Neuroscience

Functional Brain Imaging in Healthy Volunteers and Epilepsy Patients to Study Cognitive Functions
Principal investigator: Biyu J. He, PhD