Otolaryngology—Head & Neck Surgery Clinical Research | NYU Langone Health

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Department of Otolaryngology—Head & Neck Surgery Research Otolaryngology—Head & Neck Surgery Clinical Research

Otolaryngology—Head & Neck Surgery Clinical Research

Investigators in NYU Langone’s Department of Otolaryngology—Head and Neck Surgery are committed to advancing the field with groundbreaking clinical research on cochlear and auditory brainstem implants and vocal fold scarring.

As active participants in clinical research, we offer our patients the latest treatments and therapies for hearing loss and voice disorders. Our faculty members regularly share research findings at national and international conferences and in peer-reviewed medical journals.

Current Clinical Trials

The following clinical trials are underway at in the Department of Otolaryngology—Head and Neck Surgery.

A Phase I Open-Label Study of GSK3174998 Administered Alone and in Combination with Anticancer Agents Including Pembrolizumab in Subjects with Selected Advanced Solid Tumors
Investigator: Daniel C. Cho, MD

A Phase II Open-Label Randomized Controlled Study of PDR001 in Patients with Moderately Differentiated/Undifferentiated Locally Advanced Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC) Who Progressed on Standard Treatment
Investigator: Zujun Li, MD

A Phase II Study of REGN2810, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1) in Patients with Advanced Cutaneous Squamous Cell Carcinoma
Investigator: Anna C. Pavlick, DO

Assessment of Treatment Response of Nasopharyngeal Cancer Using Simultaneous 18F-FDG-PET and MRI
Investigator: S. Gene Kim, PhD

A Prospective Multi-Site Trial of a Point of Care Saliva-Based Detection Test Based 
on Soluble CD44 (OncAlert) for Presence of Disease in Previously Untreated Oral Cavity and Oropharynx Squamous Cell Carcinoma

Investigator: Brian L. Schmidt, MD, PhD, DDS

Auditory Brainstem Implant (ABI) in Children with No Cochleae or Auditory Nerves
Investigators: J. Thomas Roland Jr., MD, and Susan B. Waltzman, PhD

Cochlear Implantation in Adults with Asymmetric Hearing Loss Clinical Trial
Investigator: Susan B. Waltzman, PhD

Evaluation of Revised Indications (ERID) for Cochlear Implant Candidacy for the Adult CMS Population
Investigator: Susan B. Waltzman, PhD

High-Intensity Group Vocal Exercise to Improve Laryngeal Function in Patients with Parkinson’s Disease
Investigator: Aaron M. Johnson, PhD

Implantation of the HiRes90K Advantage Cochlear Implant with HiFocus Mid-Scala and Development of a Combined Electric and Acoustic Stimulation Technology in Adults with Partial Deafness
Investigator: J. Thomas Roland Jr., MD

Investigation of Human Laryngeal Evoked Brainstem Potentials
Investigator: Milan R. Amin, MD

Investigation of the Role of Steroids in Enhancing Voice Therapy Outcomes
Investigator: Milan R. Amin, MD

Clinical Investigation of New Cochlear Implant Delivery Models in an Adult Nucleus CI Population
Investigator: Susan B. Waltzman, PhD

Investigation of the FAST Sound Coding Strategy in Newly Implanted Adult Cochlear Implant Recipients
Investigator: Susan B. Waltzman, PhD

Observational Study of Dental Outcomes in Head and Neck Cancer Patients (ORARAD)
Investigator: Brian L. Schmidt, MD, PhD, DDS

Phase II: Adaptive De-Escalation of Radiation Therapy Dose in Favorable Risk HPV-Positive Oropharyngeal Carcinoma (ART)
Investigators: Milan R. Amin, MD; Mark D. DeLacure, MD; Babak Givi, MD; Adam S. Jacobson, MD; Mark S. Persky, MD

Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)
Investigator: Kenneth S. Hu, MD

Study to Compare Avelumab in Combination with Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck (JAVELIN HEAD AND NECK 100)
Investigator: Zujun Li, MD

1456GCC A Phase II Trial of Reirradiation Combined with Open-Label MK-3475 (Pembrolizumab) in Patients with Locoregional Inoperable Recurrence or Second Primary Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Investigator: Zujun Li, MD

Clinical Outcomes Research

Faculty, residents, and medical students in the Department of Otolaryngology—Head and Neck Surgery have several additional ongoing clinical outcomes research projects underway.

Our current initiatives include the following:

  • examining quality-of-life changes among children who receive auditory brainstem implants, including case studies of children with a cochlear implant in one ear and an auditory brainstem implant in the other
  • studying the effect of later-diagnosed disabilities on cochlear implant performance among children who received implants before 12 months of age
  • assessing barriers to cochlear implantation among low-income families
  • determining causal factors for operating room infections during cochlear implant surgery
  • analyzing the epidemiological characteristics of patients with recurrent vocal fold leukoplakia
  • conducting cost analyses of radiotherapy versus microlaryngeal surgery for early glottic cancer and channeled, distal chip laryngoscope for in-office laryngopharyngeal biopsies
  • examining variability on the Voice Handicap Index-10 over time

For more information about clinical trials and clinical outcomes research, contact Kristin Montella, division administrator, research, and academic operations, at kristin.montella@nyulangone.org or 212-263-8182.