Experts in NYU Langone’s Division of Bariatric Surgery conduct clinical trials that help advance the practice of weight loss medicine. If you are interested in learning more about or participating in any of our studies, contact Gabrielle Maranga, research manager, at 212-263-2174 or gabrielle.maranga@nyulangone.org.

Current Clinical Trials

Following are our division’s current trials.

Efficacy and Safety of Tirzepatide Once Weekly in Participants Without Type 2 Diabetes Who Have Obesity or Are Overweight with Weight-Related Comorbidities: A Randomized Double-Blind Placebo-Controlled Trial

This study tests the investigational drug tirzepatide, to discover how well it works to help people with excess weight or obesity with weight-related conditions such as high blood pressure, high cholesterol, obstructive sleep apnea, or cardiovascular disease.

Principal investigator: Holly F. Lofton, MD

Knee Osteoarthritis Pre- and Post-Bariatric Surgery and Medical Weight Loss Biomarker Study

The purpose of this study is to evaluate knee osteoarthritis and its associated pain in patients with obesity scheduled to have bariatric surgery or a monitored weight loss program.

Principal investigator: Jonathan Samuels, MD

Semaglutide Obesity Trial

The purpose of this study is to determine whether semaglutide may reduce the risk of cardiovascular events—stroke, heart attack, and other conditions that damage the heart—in patients with excess weight or obesity who have prior cardiovascular disease.

Principal investigator: Holly F. Lofton, MD

SWIFT Trial: Surgical Weight Loss to Improve Functional Status Trajectories Following Total Knee Arthroplasty

The purpose of this study is to determine whether weight-loss surgery before total knee arthroplasty surgery reduces risk and improves long-term outcomes.

Principal investigator: Jonathan Samuels, MD

Other Division Research

In addition to the trials above, our division faculty conduct and participate in studies such as the following:

• a long-term study investigating the effects of gastric banding on adolescents
• quality improvement studies that seek to enhance surgical outcomes and patient quality of life
• a retrospective chart review study investigating symptoms of gastroesophageal reflux disease after bariatric surgery

As one of the oldest programs in the nation, we provide data to the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program.

Bariatric Surgery Faculty Publications

Faculty in NYU Langone’s Division of Bariatric Surgery publish in the field’s most respected peer-reviewed publications.