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Division of Endocrine Surgery Endocrine Surgery Research

Endocrine Surgery Research

Faculty in the Division of Endocrine Surgery at NYU Grossman School of Medicine conduct ongoing clinical and scientific research, in addition to treating patients who have endocrine conditions. We conduct a wide array of multidisciplinary research projects, all with the goal of ultimately improving the care of our patients.

Our goal is to learn more about the natural history of thyroid cancer and the molecular changes that may make some types of cancer more aggressive than others.

Through this type of research, we aim to individualize patient care by identifying those who need to be treated more aggressively, as well as those who may not need to be treated at all. We are continually evaluating new surgical techniques to further decrease the risk of thyroid and parathyroid surgery and minimize patient discomfort.

Our research, led by Kepal N. Patel, MD, seeks to understand the mechanisms controlling the mitogen-activated protein kinase (MAPK) pathway in order to provide valuable insight into thyroid progression. As the MAPK pathway has been implicated in other types of cancer, including pancreatic cancer, colon cancer, and melanoma, Dr. Patel’s research is applicable to multiple diseases.

The goal of our research program is to identify molecular factors that may serve as prognosticators and potential therapeutic targets for aggressive thyroid carcinoma. Dr. Patel was awarded a grant from the Thyroid, Head and Neck Cancer (THANC) Foundation in cooperation with the American Thyroid Association for his research in thyroid cancer.

Dr. Patel is also the lead author of the first set of evidence-based guidelines to surgically manage adult thyroid disease, including thyroid nodules and cancer. By describing and evaluating the evidence and risk–benefit ratio of clinical recommendations, the guidelines support clinical decision-making.

Endocrine Surgery Faculty Publications

Faculty in our division publish in the field’s most respected peer-reviewed publications.

Molecular Profiling of 50,734 Bethesda III-VI Thyroid Nodules by ThyroSeq v3: Implications for Personalized Management

Chiosea, Simion; Hodak, Steven P; Yip, Linwah; Abraham, Devaprabu; Baldwin, Chelsey; Baloch, Zubair; Gulec, Seza A; Hannoush, Zeina C; Haugen, Bryan R; Joseph, Lija; Kargi, Atil Y; Khanafshar, Elham; Livhits, Masha J; McIver, Bryan; Patel, Kepal; Patel, Snehal G; Randolph, Gregory W; Shaha, Ashok R; Sharma, Jyotirmay; Stathatos, Nikolaos; van Zante, Annemieke; Carty, Sally E; Nikiforov, Yuri E; Nikiforova, Marina N

Journal of clinical endocrinology & metabolism. 2023 Oct 18; 108:2999-3008

General Principles for the Safe Performance, Training, and Adoption of Ablation Techniques for Benign Thyroid Nodules: An American Thyroid Association Statement

Sinclair, Catherine F; Baek, Jung Hwan; Hands, Kathleen E; Hodak, Steven P; Huber, Timothy C; Hussain, Iram; Lang, Brian Hung-Hin; Noel, Julia E; Papaleontiou, Maria; Patel, Kepal N; Russ, Gilles; Russell, Jonathon; Spiezia, Stefano; Kuo, Jennifer H

Thyroid : official journal of the American Thyroid Association. 2023 Oct ; 33:1150-1170

The Current Status of Minimally Invasive Adrenalectomy for Aldosterone Producing Adenoma: Controversial Issues, and Realistic Expectations of Clinical Cure

Pachter, Hersch Leon; Arthurs, Likolani; Sant, Vivek; Underwood, Hunter; Kulkarni, Kopel; Parikh, Manish; Agrawal, Nidhi; Suh, Insoo; DiMaggio, Charles

Journal of endocrine surgery. 2023 Jun; 23:27-39

Invited Commentary: The Path Toward Broader Validation and Adoption of Transoral Thyroidectomy

Suh, Insoo; Patel, Kepal N

World journal of surgery. 2023 May ; 47:1209-1210

Case Report: Giant Thyroid Angiolipoma-Challenging Clinical Diagnosis and Novel Genetic Alterations

Wilkins, Reid; Zan, Elcin; Leonardi, Olga; Patel, Kepal N; Jacobson, Adam S; Jour, George; Liu, Cheng Z; Zhou, Fang

Head & neck pathology. 2023 Mar ; 17:246-252

Implementation of a formal sleep center-based screening protocol for primary aldosteronism in patients with obstructive sleep apnea

Wright, Kyla; Mahmoudi, Mandana; Agrawal, Nidhi; Simpson, Hope; Lui, Michael S; Pachter, H Leon; Patel, Kepal; Prescott, Jason; Suh, Insoo

Surgery. 2023 Jan ; 173:59-64

The clinical significance of the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) category 5 thyroid nodules: Not as risky as we think?

Wright, Kyla; Brandler, Tamar C; Fisher, Jason C; Rothberger, Gary D; Givi, Babak; Prescott, Jason; Suh, Insoo; Patel, Kepal N

Surgery. 2023 Jan ; 173:239-245

The Year in Thyroidology: Surgical Science

Patel, Kepal N

Thyroid. 2023 Jan ; 33:21-23