Researchers in the Mood Disorders and Cognition (MDC) research program in NYU Langone’s Department of Psychiatry investigate the neurobiology of mood and cognition disorders, including major depression, bipolar disorder, Alzheimer’s disease, and novel treatments for these conditions, including pharmacological agents and brain stimulation strategies.

The program is led by Dan Iosifescu, MD, MSc. His past work includes the clinical and mechanistic study of novel, rapidly acting treatments for mood disorders, such as ketamine, minocycline, low field magnetic stimulation, and the recognition and treatment of cognitive deficits associated with mood disorders. His current studies focus on transcranial photobiomodulation—which is being tested, separately, in subjects with major depression and in those with early-stage Alzheimer’s disease—and the comparison of several treatments for bipolar depression.

In addition to serving as principal investigator in several large, multicenter trials of new therapies in major depression, bipolar disorder, and Alzheimer’s disease, Dr. Iosifescu has led key studies using functional MRI (fMRI), magnetic resonance spectroscopy, ¹⁸F-MK6240 PET, and quantitative electroencephalography to investigate associated neurobehavioral substrates.

Clinical Trials

Descriptions of our current clinical trials are below.

Transcranial Near-Infrared Radiation and Cerebral Blood Flow in Depression, R33 (TRIADE-R33)

Our researchers are determining if application of near-infrared energy to the forehead can change depressive symptoms and the blood flow in the brains of people with depression, by comparing near-infrared laser exposure with a placebo or sham procedure. For more information about this trial, including eligibility requirements, please contact Zamfira Parincu at Zamfira.Parincu@NYULangone.org, or Anna Petersonat Anna.Peterson@NYULangone.org. View full clinical trial information.

Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD)

Our researchers are testing the efficacy and safety of 24 sessions of transcranial photobiomodulation (t-PBM) with near-infrared light, delivered over eight weeks and compared to sham, in improving clinical symptoms of mild cognitive impairment and early Alzheimer’s disease. Additionally, we explore the brain mechanisms of t-PBM with advanced neuroimaging. For more information about this trial, including eligibility requirements, please contact Zamfira.Parincu@NYULangone.org or Anna Peterson at Anna.Peterson@NYULangone.org. View full clinical trial information.

A Pilot Phase II Open-Label, Single-Center Study of Sodium-Glucose Cotransporter-2 Inhibitor Empagliflozin in Major Depressive Disorder (SGLT2-MDD)

Led by David T. Liebers, MD, MPil, MPP, our researchers are testing the antidepressant effects of empagliflozin, the generic form of Jardiance, a medication commonly prescribed for Type 2 diabetes, in patients with major depressive disorder. We also explore the effects that empagliflozin has on metabolic markers, ketogenesis, and gut microbiome. For more information about this trial, including eligibility requirements, please contact Zamfira Parincu at Zamfira.Parincu@NYULangone.org or Anna Peterson at Anna.Peterson@NYULangone.org. View full clinical trial information.

A Single-Center Observational Study of Reference Point Setting in Major Depressive Disorder (RESET-MDD)

Led by Paul W. Glimcher, PhD, this study seeks to investigate how affective mood can have negative effects on people’s decision-making processes and how this can perpetuate major depressive disorder. Our researchers use behavioral decision-making paradigms to elucidate these mechanisms. For more information about this trial, including eligibility requirements, please contact Zamfira Parincu at Zamfira.Parincu@NYULangone.org or Anna Peterson at Anna.Peterson@NYULangone.org.

Sequential Multiple Assignment Randomized Trial for Bipolar Depression: SMART-BD

As a part of a multicentered clinical trial led by Andrew Nierenberg, MD, and funded by the Patient-Centered Outcomes Research Institute (PCORI), our researchers will address how to best treat people with bipolar disorder who are experiencing major depressive episodes. In this trial, we aim to compare the safety and effectiveness of three U.S. Food and Drug Administration (FDA)–approved medications for the treatment of bipolar depression—cariprazine, lurasidone, and quetiapine—with a commonly used antipsychotic and antidepressant combination, namely aripiprazole and escitalopram. For more information about this trial, including eligibility requirements, please contact Zamfira Parincu at Zamfira.Parincu@NYULangone.org or Anna Peterson at Anna.Peterson@NYULangone.org. View full clinical trial information.

Assessment of Glutamate Neurotransmission, Brain Bioenergetics, and Neuroinflammation in Major Depressive Disorder Using TSPO PET and MRI

This study, led by Steven H. Baete, PhD, uses advanced neuroimaging techniques to assess neuroinflammation in patients with major depressive disorder and healthy volunteers. For more information about this trial, including eligibility requirements, please contact Zamfira Parincu at Zamfira.Parincu@NYULangone.org or Anna Peterson at Anna.Peterson@NYULangone.org. View full clinical trial information.

Current Grants

We receive funding from the National Institutes of Health (NIH), National Institutes of Mental Health (NIMH), not-for-profit research organizations, and private industry.

Grants we have received from the NIH include the following:

• Transcranial Near-Infrared Radiation and Cerebral Blood Flow in Depression (TRIADE; NIH, R61-R33 MH122647)
• Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD; NIH-NIA, R01 AG068248)

Grants from the Alzheimer’s Association include the following:

• Photobiomodulation for Early Stage Alzheimer's Disease (PhESAD)

Grants from the Patient-Centered Outcomes Research Institute (PCORI) include the following:

• Sequential Multiple Assignment Randomized Trial for Bipolar Depression (SMART-BD)
• Augmentation versus Switch: Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders with Treatment Resistant Depression (ASCERTAIN-TRD) (Grant Completed)

Research Training

Dr. Iosifescu advises NYU Grossman School of Medicine psychiatry residents who are interested in conducting research on mood disorders.

Research Faculty and Staff

Dan Iosifescu, MD, MSc
Mood Disorders and Cognition Research Program, Director

Ricardo M. Osorio Suarez, MD
Associate Professor of Psychiatry

Kathy F. Yates, PhD
Research Associate Professor of Psychiatry, Senior Neuropsychologist

David T. Liebers, MD, MPil, MPP
Chief Resident, Psychiatry PGY-4

David is chief resident and part of the research career development pathway in the psychiatry residency program at NYU Grossman School of Medicine. His focus is clinical research on novel therapeutics for psychiatric conditions that target abnormal brain bioenergetic metabolism and treatments that could potentially be disease modifying. He earned an MD and MPP from Harvard Medical School and Harvard Kennedy School where his research focused on the application of polygenic risk scores to illness course in mood disorders. He is a graduate of the University of Rochester, and read history and philosophy of science for an MPhil at the University of Cambridge on a Gates Scholarship.

Simon Khuvis, MD, PhD
Resident, Psychiatry PGY-4

Simon received his bachelor’s degree in engineering from the Cooper Union and his MD and PhD from the Zucker School of Medicine at Hofstra/Northwell. In graduate school, he worked in the laboratory of Dr. Ashesh Mehta, studying the single-unit correlates of visual memory and epilepsy biomarkers in patients undergoing intracranial EEG monitoring. He is currently pursuing a research track residency at NYU Grossman School of Medicine, with a specialization in psychiatry. His research interests include novel devices for the treatment of cognitive disorders.

Naomi L. Gaggi, PhD
Postdoctoral Fellow

Naomi is a postdoctoral research fellow who earned her PhD in neuroscience in 2022. She is currently working on identifying profiles of cerebral metabolism in multiple clinical populations, including Alzheimer’s disease and individuals with sleep disorders. She is using multimodal neuroimaging and understanding how transcranial photobiomodulation can enhance blood flow and metabolism in these populations. She is also a T32 fellow in sleep science (T32HL160511) under the guidance of Dr. Osorio Suarez and Dr. Iosifescu.

Anna L. Peterson, MA
Research Data Associate

Anna earned her master’s degree in psychology from NYU in 2022. She aspires to earn a doctorate in neuroscience, and her research interests include the relationship between mood and cognition, psychedelic therapies, and temporal lobe seizure activity. Anna conducts research trials and studies in the Mood Disorders and Cognition Research Program.

Zamfira Parincu, BA
Research Data Associate

Zamfira earned her bachelor’s degree in psychology from Columbia University in 2021. She is interested in leveraging cognitive factors to study the etiology and pathology of mood disorders. Zamfira aspires to pursue a doctorate in clinical psychology to advance research in mood disorders. She conducts research trials and studies in the Mood Disorders and Cognition Research Program.

Jacqueline Hilbert, BS
Research Data Associate

Jacqueline earned her bachelor’s degree in legal studies from St. John’s University in 2022. She is currently pursuing a master’s degree in psychology at St. John’s University. Jacqueline spends a majority of her time working on the TRAP-AD and TRIADE-R33 studies and aspires to build a career in the field of clinical psychology.

Program Alumni and Current Placement

Yoonju Cho, MD, PhD
Clinical Psychiatry Fellow, Massachusetts General Hospital

Ram Sharma, MD
Clinical Instructor of Psychiatry and Human Behavior, Sidney Kimmel Medical College, Thomas Jefferson University

Ellen Krotow, RN
Staff Nurse, NYU Langone Acute Neuroscience Unit

Arwa Adib, BA
PhD Student, University of Oregon Department of Psychology

Anthony (Xiaotong) Song, MA
PhD Students, University of Kentucky Department of Psychology

Zanetta Kovbasyuk, MS
Assistant Research Scientist, NYU Langone’s Department of Neurology

Yumiko Wiranto, MA
PhD Student, University of Kansas Department of Psychology

Dongni Yan, MA
Associate Research Coordinator, NYU Langone’s Neuroscience Institute

Weiqi (Vicky) Xu, MA
Research Coordinator, Chinese Academy of Sciences-Institute of Neuroscience, People’s Republic of China

Hanna Lissinna, MA
Graduate Research Assistant, NYU Silver School of Social Work

Contact Us

For more information about the Mood Disorders and Cognition Research Program, please contact Zamfira Parincu at Zamfira.Parincu@NYULangone.org or Anna Peterson at Anna.Peterson@NYULangone.org.

For more information about joining our research team, please contact Dr. Iosifescu at Dan.Iosifescu@NYULangone.org.

Featured Publications

We publish in peer-reviewed academic journals. A selection of recent work is below.