Schizophrenia Research | NYU Langone Health

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Department of Psychiatry Research Schizophrenia Research

Schizophrenia Research

The mission of the Department of Psychiatry’s schizophrenia research group is to develop more effective and better-tolerated treatments for individuals with this chronic mental illness. Under the leadership of Donald C. Goff, MD, our investigators use emerging technologies, including brain imaging, genetics, bioinformatics, and computational neuroscience, to advance our understanding of schizophrenia and identify new treatment targets.

Treatment approaches we evaluate include pharmacologic agents, cognitive remediation, cognitive behavioral therapy, mobile digital technology, and neuromodulation. Using a precision medicine model, researchers match these treatments to individual patients using novel biomarkers.

Our faculty study schizophrenia at NYU Langone’s Tisch Hospital, NYU Langone Hospital—Brooklyn, NYC Health + Hospitals/Bellevue, and the New York State Office of Mental Health’s Manhattan Psychiatric Center and 125th Street Clinic, and The Nathan S. Kline Institute for Psychiatric Research. This wide range of clinical settings allows our investigators to study both early (particularly first episode) and later-stage psychosis. We are also able to focus on groups with the greatest unmet needs, including individuals with treatment-resistant illness, negative symptoms, cognitive deficits, comorbid illness, and those with a history of self-harm or violence.

Clinical Trials

Our current trials investigate treatments that may benefit patients early in the disease process and the role of hippocampal memory circuits in delusions.

Levetiracetam in Early Psychosis

To determine whether early intervention with levetiracetam protects the brain and improves the course of schizophrenia, Dr. Goff and his colleagues are conducting a placebo-controlled, single-dose parallel group trial of levetiracetam in patients with early psychosis. We are assessing hippocampal perfusion activity with pulsed arterial spin labeling.

For more information about this study, please contact Kamber Hart, research coordinator, at 646-754-4843 or kamber.hart@nyulangone.org. View full clinical trial information.

Hippocampal Memory Circuits in Delusions

Dr. Goff and his colleagues are using three novel high-resolution task-based and post-encoding resting functional MRI paradigms (pattern separation, sequential associative mismatch, and encoding plasticity) to assess hippocampal activity in patients with first episode psychosis before and after antipsychotic treatment. Fifty first psychosis subjects and 50 healthy matched controls are being assigned to each of the 3 imaging methods. Investigators are evaluating psychosis subjects at baseline and at eight weeks after starting antipsychotic medication to determine whether changes in delusions correlate with hippocampal changes detected on imaging.

For more information about this study, please contact Kamber Hart, research coordinator, at 646-754-4843 or kamber.hart@nyulangone.org. View full clinical trial information.

Can Cognitive Training Decrease Reactive Aggression?

Through The Nathan S. Kline Institute for Psychiatric Research, Matthew J. Hoptman, PhD, and Jean-Pierre Lindenmayer, MD, are investigating whether cognitive training helps people with schizophrenia to improve emotion regulation, impulse control, and aggression. The researchers, in collaboration with Weill Medical College of Cornell University investigators, are comparing computerized cognitive remediation and social cognition training to cognitive remediation alone. Estimated enrollment is 90 people.

For more information about this study, please contact Isidora Ljuri at 646-672-6173 or isidora.ljuri@omh.ny.gov. View full clinical trial information. The National Center for Advancing Translational Sciences is providing funding to the Clinical and Translational Science Center at Weill Medical College of Cornell University to conduct this study.

Neural Correlates of Emotion Regulation in Psychosis with Suicidal Ideation and Behavior

Matthew J. Hoptman, PhD, is investigating how brain function relates to emotion regulation in 52 people with psychoses and suicidal ideation and behavior compared to 52 subjects with no psychiatric condition. He is using fMRI and novel brain imaging techniques to assess brain structure, circuitry, and function. View additional study information.

Imaging Dopamine D2 Agonist Binding Sites in Schizophrenia

W. Gordon Frankle, MD, is studying dopamine abnormalities hypothesized to be responsible for the symptoms observed in schizophrenia. He and his colleagues are applying novel brain imaging techniques to measure dopamine release, the binding of dopamine to receptors, and the impact of dopamine on working memory in subjects with schizophrenia and healthy controls. This project is designed to help researchers understand whether increased dopamine release, increased dopamine binding to receptors, or some combination of these, is responsible for the symptoms observed in schizophrenia. View additional study information.

Basic and Translational Research

To translate new findings in basic and cognitive neuroscience to the clinic, our investigators take advantage of the rich neuroscience environment at NYU Langone, employing a team approach with colleagues at the Neuroscience Institute and Skirball Institute of Biomolecular Medicine. We also work with the Center for Neural Science at NYU, and The Nathan S. Kline Institute for Psychiatry Research.

Current Grants

Our researchers are funded by National Institutes of Health and not-for-profit health foundation grants.

National Institute of Mental Health

Levetiracetam in First Episode Psychosis; NIH R61MH112833

Hippocampal Memory Circuits in Delusions; NIH R01MH112733

American Foundation for Suicide Prevention

Neural Correlates of Emotional Regulation in Psychosis with Suicidal Ideation and Behavior; 2018 Standard Research Grant

Research Training

We offer medical students, residents, and fellows basic, translational, and clinical research opportunities in schizophrenia.

Faculty

Our research faculty are experts in schizophrenia research.

Donald C. Goff, MD
Esther Blessing, MD, PhD
W. Gordon Frankle, MD
Matthew J. Hoptman, PhD
Jean-Pierre Lindenmayer, MD
Leonardo V. Lopez, MD

Contact Us

For further information about the schizophrenia research group, please contact Dr. Goff at donald.goff@nyulangone.org.

Recent Publications

Our schizophrenia research faculty publish frequently in peer-reviewed journals. Here is a selection of their recent publications.

Aberrant resting-state functional connectivity of salience network in first-episode schizophrenia

Huang, Huan; Botao, Zeng; Jiang, Yuchao; Tang, Yingying; Zhang, Tianhong; Tang, Xiaochen; Xu, Lihua; Wang, Junjie; Li, Jin; Qian, Zhenying; Liu, Xu; Wang, Huiling; Luo, Cheng; Li, Chunbo; Xu, Jian; Goff, Donald; Wang, Jijun

Brain imaging & behavior. 2020 Oct ; 14:1350-1360

Proof of mechanism and target engagement of glutamatergic drugs for the treatment of schizophrenia: RCTs of pomaglumetad and TS-134 on ketamine-induced psychotic symptoms and pharmacoBOLD in healthy volunteers

Kantrowitz, Joshua T; Grinband, Jack; Goff, Donald C; Lahti, Adrienne C; Marder, Stephen R; Kegeles, Lawrence S; Girgis, Ragy R; Sobeih, Tarek; Wall, Melanie M; Choo, Tse-Hwei; Green, Michael F; Yang, Yvonne S; Lee, Junghee; Horga, Guillermo; Krystal, John H; Potter, William Z; Javitt, Daniel C; Lieberman, Jeffrey A

Neuropsychopharmacology. 2020 Oct ; 45:1842-1850

Effect of DAOA genetic variation on white matter alteration in corpus callosum in patients with first-episode schizophrenia

Su, Wenjun; Zhu, Tianyuan; Xu, Lihua; Wei, Yanyan; Zeng, Botao; Zhang, Tianhong; Cui, Huiru; Wang, Junjie; Jia, Yuping; Wang, Jinhong; Goff, Donald C; Tang, Yingying; Wang, Jijun

Brain imaging & behavior. 2020 Aug 03;

D-cycloserine augmentation of cognitive behavioral therapy for delusions: A randomized clinical trial

Diminich, Erica D; Dickerson, Faith; Bello, Iruma; Cather, Corinne; Kingdon, David; Rakhshan Rouhakhtar, Pamela J; Hart, Kamber L; Li, Chenxiang; Troxel, Andrea B; Goff, Donald C

Schizophrenia research. 2020 Aug ; 222:145-152

Parietal memory network and default mode network in first-episode drug-naïve schizophrenia: Associations with auditory hallucination

Guo, Qian; Hu, Yang; Zeng, Botao; Tang, Yingying; Li, Guanjun; Zhang, Tianhong; Wang, Jinhong; Northoff, Georg; Li, Chunbo; Goff, Donald; Wang, Jijun; Yang, Zhi

Human brain mapping. 2020 Jun 01; 41:1973-1984

Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice: A Joint Consensus Statement of the American Society of Clinical Psychopharmacology and the Therapeutic Drug Monitoring Task Force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie

Schoretsanitis, Georgios; Kane, John M; Correll, Christoph U; Marder, Stephen R; Citrome, Leslie; Newcomer, John W; Robinson, Delbert G; Goff, Donald C; Kelly, Deanna L; Freudenreich, Oliver; Piacentino, Daria; Paulzen, Michael; Conca, Andreas; Zernig, Gerald; Haen, Ekkehard; Baumann, Pierre; Hiemke, Christoph; Gründer, Gerhard; Pharmakopsychiatrie, The Therapeutic Drug Monitoring Task Force Of The Arbeitsgemeinschaft Für Neuropsychopharmakologie Und

Journal of clinical psychiatry. 2020 05 19; 81:

Optical coherence tomography of the retina in schizophrenia: Inter-device agreement and relations with perceptual function

Miller, Margaret; Zemon, Vance; Nolan-Kenney, Rachel; Balcer, Laura J; Goff, Donald C; Worthington, Michelle; Hasanaj, Lisena; Butler, Pamela D

Schizophrenia research. 2020 May ; 219:13-18

Reduced Microstructural Lateralization in Males with Chronic Schizophrenia: A Diffusional Kurtosis Imaging Study

McKenna, Faye; Babb, James; Miles, Laura; Goff, Donald; Lazar, Mariana

Cerebral cortex. 2020 Apr 14; 30:2281-2294