Research

 

The Fresco Institute seeks to fundamentally advance the understanding and treatment of Parkinson’s disease and movement disorders. By bringing together basic scientists, clinician scientists, and clinicians, we strive to develop innovative concepts and research programs related to these disorders. The strong and growing interactions between basic and clinical departments within NYU and with institutions of scientific and higher learning in Italy provide a unique scope and community engaged in this important mission.

To achieve significant progress in the understanding and treatment of Parkinson’s disease and movement disorders, the Fresco Institute engages basic researchers and clinician scientists from the Neuroscience Institute, Neurology, and Neurosurgery, who meet and interact with one another on a regular basis to collectively investigate fundamental research in the following areas:

  • Understanding the mechanisms of neurodegeneration underlying Parkinson’s disease
  • Identifying the cells and molecules that control the release of dopamine in the brain
  • Uncovering the brain circuits that control the selection, initiation, and execution of voluntary movements
  • Revealing how movement-related brain circuits change in Parkinson’s disease to give rise to decreased motor performance, tremor, and postural instability
  • Gaining a better understanding of the non-motor complications of Parkinson's disease, such as depression, cognitive impairments, sleep disorders, impulse control disorders, and autonomic dysfunction
  • Investigating new pharmacological and non-pharmacological therapies for motor and non-motor symptoms of Parkinson’s disease
  • Devising non-invasive neurostimulation paradigms and physical exercise routines to provide long-term improvements in motor and cognitive performance
  • Developing innovative models of care that demonstrably improve the quality of life of patients, caregivers, and their families.

Please browse the links at left to learn more about our team of basic and clinical researchers, ongoing clinical trials for Parkinson’s and movement disorders, and a list of recently completed studies and research publications.