Role of the Receptor for Advanced Glycation Endproducts | NYU Langone Health

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Nolan Lab Research Role of the Receptor for Advanced Glycation Endproducts

Role of the Receptor for Advanced Glycation Endproducts

The Nolan Lab studies particulate matter-related lung disease in collaboration with the FDNY WTC Data Center and the FDNY WTC Health Program. We have demonstrated that mediators of metabolic syndrome, vascular disease, and inflammation predict development of abnormal lung function.

Graphic Listing Histopathology, Echocardiography, PET and CT Scans, and Biomarkers as Research Technologies Used by the Lab
We use a range of technologies to demonstrate a connection between particulate matter exposure and lunch disease.

Led by principal investigator Anna Nolan, MD, the lab’s major focus is to understand the roles of the receptor for advanced glycation endproducts (RAGE) and lysophosphatidic acid (LPA), a product of LDL cholesterol, in lung disease. Dr. Nolan performs these studies in collaboration with Ann Marie Schmidt, MD, in the Diabetes Research Program, who discovered RAGE and recently identified LPA as a novel ligand of RAGE.

Flow Chart Showing the Connection Between Particulate Matter and Lung Disease
We aim to understand the role of RAGE in particulate matter associated disease.

Dr. Nolan’s group translated the lab’s clinical observations into a murine model of particulate exposure while working with Lung-Chi Chen, PhD, and Terry Gordon, PhD. More recently we have assessed vascular measures and morphology in collaboration with Youssef Zaim Wadghiri, PhD, in the Preclinical Imaging Laboratory.

Related Publications

Caraher EJ … Nolan A. Receptor for advanced glycation end products contributes to particulate matter associated loss of lung function and hyperreactivity. PLoS ONE. 2017.

Haider SH … Nolan A. Receptor for advanced glycation end-products and environmental exposure related obstructive airways disease: A systematic review. Eur Respir Rev. 2019. DOI.