Available Positions for Postdoctoral Fellows
At NYU School of Medicine, we frequently post new opportunities for postdoctoral fellows to join our team of world-class biomedical investigators.
If you are interested in applying for an available position, please contact the principal investigator directly using the contact information included with the position listing. You might find additional postdoc opportunities by searching the NYU School of Medicine website for a researcher or department that interests you. There may be additional research opportunities available.
NYU School of Medicine researchers who have an available postdoctoral position they would like to add to this list can submit the new postdoctoral position submission form.
Current postdocs nearing the end of their appointment can log into the postdoc community using their Kerberos ID to browse a list of job openings. Faculty and administrators from outside institutions who wish to add a job opening to this list can do so by submitting a career opportunity form.
Current Postdoctoral Openings
NYU School of Medicine is an equal opportunity employer committed to fostering diversity for postdoctoral fellows in the workplace. The following positions offer competitive salaries, excellent benefits, and eligibility for student housing.
Chromosome Architecture in Cancer Research—April 18, 2018
Postdoctoral positions are available in the laboratory of Jane Skok, PhD, in both our wet lab and dry lab, to work on chromosome architecture in cancer research. The Skok Lab combines sophisticated experimental (fluorescent in situ hybridization; live imaging; and chromosome conformation capture, or 3C) and analytical aspects of chromosome folding with the tools of genetics to understand how higher-order mechanisms help preserve genome integrity and regulate gene expression.
For the wet lab postdoc, we would prefer experience in 3C and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR). The dry lab postdoc should have experience in next generation sequencing data, 3C, and modeling analysis.
Candidates are expected to establish independent research projects and to produce high-impact publications, which should provide postdoctoral fellows with an excellent opportunity for further career development in academia.
Development of Recombinant Botulinum Neurotoxin Derivatives—April 6, 2018
The laboratory of Konstantin Ichtchenko, PhD, is seeking a senior postdoctoral associate to conduct cutting-edge research in designing, expressing, and purifying protein biopharmaceuticals for neurological disease. The research involves first-in-class fusion proteins that enable delivery of single domain antibodies, polypeptides, and small molecules to the cytoplasm of neurons without a viral vehicle. Our research program is heavily focused on translational research, and experience in development of biopharmaceutical processes is desirable. The recruited individual leads an effort to engineer, express, purify, and test recombinant proteins with unique and specified characteristics as neuron-targeting delivery vehicles.
Candidates’ responsibilities include bioengineering recombinant proteins with unique characteristics, leading the expression and purification processes of proteins, establishing in vitro testing methods, and collaborating with experts in the development of GMP (good manufacturing practices) processes for the pilot production of therapeutic compounds.
The following are the required qualifications for this role:
- PhD degree in molecular biology, biochemistry, bioengineering, or related disciplines
- extensive experience in gene cloning, protein engineering, expression, and purification
- knowledge and experience in protein chemistry, protein conjugation, and protein labeling
- basic understanding of the GMP manufacturing process for protein pharmaceuticals. Experience is highly desirable, but not essential.
- broad experience in protein expression systems, including insect cell culture, mammalian expression systems, and prokaryotic expression systems
- broad experience in protein purification using multiple methods—affinity chromatography, ion exchange chromatography, size exclusion, and others
- broad experience in analytical biochemistry (e.g., Western blotting, immunoprecipitation, flow cytometry, and development of batch records and product specifications)
- strong data analysis, interpretation, and troubleshooting skills
- strong work ethic, purpose driven, self-motivated, and timeline focused
To apply, please send a CV with a brief description of your research experience and career goals to Dr. Ichtchenko at firstname.lastname@example.org. The deadline to apply is April 30, 2018.
Genome Editing to Model and Treat Monogenic Diseases—March 21, 2018
A postdoctoral position is available immediately in the laboratory of Chengzu Long, PhD, at NYU Langone’s Leon H. Charney Division of Cardiology and Helen L. and Martin S. Kimmel Center for Stem Cell Biology. Our projects focus on advancing the novel genome-editing technology to model and treat cardiac and neuromuscular diseases. For more information, see Long and colleagues in JAMA Neurology.
Monogenic disorders affect millions of people worldwide. The recent advance in novel precision genome-editing technologies and human pluripotent stem cell biology are revolutionizing our approach to study the pathology of diseases and eventually to develop the potential therapeutics for these diseases. Using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system-mediated genome editing, we successfully prevented muscular dystrophy in the mouse model. For more information, see Long and colleagues in Science 2014 and Science 2016.
We are optimizing genome-editing strategies on the culprit genes in patients’ cardiomyocytes, three-dimensional engineered heart muscle (for more information, see Long and colleagues in Science Advances and Zhang and colleagues in Science Advances) and novel animal models (for more information, see Amoasii and colleagues in Science Translational Medicine).
The ideal candidate holds a PhD and/or MD in biological sciences or biomedical-related fields. Candidates with expertise in stem cell biology and neuroscience are particularly encouraged to apply.
To apply or to obtain more information about this position, please contact Dr. Long at email@example.com. Applicants should include a CV, brief statement of research background, and names of three references.
Stem Cell and Regeneration—March 6, 2018
Two full-time postdoctoral researcher positions are available in the Hansjörg Wyss Department of Plastic Surgery at NYU Langone, in the laboratory of Catherine Lu, PhD. The laboratory investigates the basic biology of stem cell in the skin using sweat gland as a model system. Analysis of genetic mouse models and molecular, cell biological, and biochemical analysis in genetically manipulated cells are applied to study the wound repair and regeneration of the skin. For more information, see Lu and colleagues in Science.
The successful candidate is expected to develop a research project with the principal investigator, using a diverse array of laboratory techniques to address fundamental questions in skin biology and regenerative medicine. The candidate must be highly motivated and passionate about research, have good communication skills, keep clean and highly organized experimental records, and work efficiently and collaboratively as part of our team. Excellent work is expected to lead to publication in high-impact journals, and the researcher is supported to present in international conferences.
We are seeking highly motivated and productive individuals with a PhD in biology or any related field in biomedical sciences. Candidates with expertise in bioinformatics, neuroscience, or biomedical engineering are considered with priority. You should possess excellent knowledge in molecular biology and cell biology; the ability to think and work independently; experience in handling mice, mammalian cell culture, and molecular cloning; experience with immunofluorescent staining and flow cytometry (preferred); ability to multitask, take initiative, be creative, and to start and complete projects; and proficiency in computer skills (MS Office and Adobe Creative Suite), database management, and image analysis software.
Please email a cover letter explaining relevant research experience and your specific interest in our lab, a detailed CV, and names and contact information of three references. Applications are only considered if all three documents are received. Please send your application materials to Dr. Lu at firstname.lastname@example.org and Renee McKell, senior research coordinator, at email@example.com.
Melanoma Biomarker Research—March 2, 2018
A postdoctoral position is available in laboratory of David Polsky, MD, PhD, to study circulating cell-free tumor DNA and participate in the development of clinical tests to assist in the management of patients with melanoma and glioblastoma.
The Polsky Laboratory is part of the Cutaneous Biology Center and Interdisciplinary Melanoma Cooperative Group at NYU Langone’s Perlmutter Cancer Center. The current focus of the lab is the analytical and clinical validation of droplet digital PCR assays to detect specific mutations in the plasma of cancer patients, with plans to test the clinical utility of these assays in prospective clinical trials. For an example of the work being done in the laboratory, see Chang and colleagues in Molecular Oncology.
This position provides training in translational research for those holding a doctoral degree, both physicians and nonphysicians, who are committed to furthering their personal development and scholarly training in preparation for a position in academia, industry, or government, focused in the areas of cutaneous biology and skin disease. Candidates should have experience with DNA extraction and PCR-based mutation detection methods. Preference is given to applicants with a background in mutation detection from human materials (e.g., plasma or tumor samples).
Successful candidates are expected to apply for training support though all available mechanisms, including the NYU Cutaneous Biology and Skin Disease Training Program (T32 AR064184). To be eligible to apply for T32 support, applicants should have recently completed their PhD degree and must be legal U.S. citizens or permanent residents.
Highly motivated recent PhD and MD/PhD graduates who are interested in the field of cell-free DNA and helping to bring new molecular tools to the clinic in the care of patients with skin diseases and cancers are encouraged to apply and should be available for an interview.
Please send a cover letter explaining relevant work experience; a CV; and the names, telephone numbers, and email addresses of three references by email to Dr. Polsky at firstname.lastname@example.org.
Structural and Biophysical Research on JAK2 Tyrosine Kinase—March 2, 2018
A postdoctoral position is available immediately in the laboratory of Stevan Hubbard, PhD, at NYU Langone’s Skirball Institute of Biomolecular Medicine. The Hubbard Lab seeks a highly motivated individual interested in continuing our structural and biophysical studies of JAK2 tyrosine kinase (for more information, see Bandaranayake and colleagues in Nature Structural and Molecular Biology and Shan and colleagues also in Nature Structural and Molecular Biology). Applicants should have a PhD in structural biology, biophysics, or biochemistry and a record of publication. A brief letter of interest, a CV, and the names of two to three references should be sent to Dr. Hubbard at email@example.com.
HIV Virology and Immunology—February 27, 2018
Postdoctoral positions are available in the laboratory of Nathaniel Landau, PhD, in the Department of Microbiology at NYU Langone to study host restrictions to HIV replication. Our research focuses on understanding the mechanisms by which cells restrict virus replication, the innate immune response and T cell response to infection, viral mechanisms of immune evasion, the identification of new restriction factors, and the development of gene therapy-based approaches to treat AIDS using mouse models.
The applicant joins a research team funded by the National Institutes of Health (NIH) that takes innovative approaches to probe important questions in molecular virology using molecular biology, genomics, and proteomics. NYU Langone offers a rich scientific and intellectual environment for collaborative projects and provides an array of cutting-edge instrumentation and core facilities. Salaries are within the NIH postdoctoral guidelines and based on experience. Subsidized housing is available and benefits are included.
The candidate must hold a PhD degree and have a strong background in molecular biology with a record of publication in virology or a related field and experience with flow cytometry, Western blotting, tissue culture, and plasmid vector construction. You must be independent, motivated, ambitious, and interested to join an interactive and diverse research group.
Email your CV, a brief statement of research interests, and contact information for three references to Dr. Landau at firstname.lastname@example.org.
Vascular Biology Research—February 21 , 2018
A postdoctoral position is available in the laboratory of Jesús Torres-Vázquez, PhD, at NYU Langone’s Skirball Institute of Biomolecular Medicine. The Torres-Vázquez Lab studies the formation, remodeling, and function of the vascular system in the zebrafish with emphasis on vascularization of the central nervous system and endothelial barriergenic differentiation during development and disease, molecular and cellular mechanisms of vessel assembly and lumenization, and anatomical patterning of angiogenic growth by guidance cues.
We are seeking a candidate who has an exceptional publication record, research experience with model organisms, and experience with genetics, cell biology, confocal microscopy, gene expression analysis, bioinformatics, quantitative biology, genomics, cell culture, or biochemistry. In addition, you should possess excellent verbal and written communication skills.
To apply, please email your CV to Dr. Torres-Vázquez at email@example.com with the following subject line: Postdoctoral Applicant 2018: Your Name. Include the following information at the top of your CV:
- name; address (city, state, country); and telephone
- availability date
- degree(s), date(s) awarded, and GPA(s)
- name, title, email, and phone number of three references
- a short paragraph describing your scientific interests, experience, and career goals
- a summary of your doctoral thesis or current research project written for the general public
Diabetic Cardiovascular Disease—February 12, 2018
A postdoctoral position is available immediately in NYU Langone’s Diabetes Research Program for studies in the field of diabetic cardiovascular disease. Our research involves the following:
- developing multidimensional approaches to examine the mechanisms whereby the cardiovascular system responds to stress or injury in diabetes
- applying the knowledge gained to develop therapeutic strategies to prevent, slow, or reverse the progression of diabetic cardiovascular disease.
An ideal applicant should have a doctoral degree (PhD or MD/PhD) and must have solid experience with contemporary techniques in the study of cardiovascular disease, preferably with an emphasis in cardiovascular physiology. Expertise with mice cardiac surgery, vascular surgery, and measurements of cardiovascular function is essential. In addition, experience with cellular and molecular techniques, as well as the use of proteomics and/or metabolomics, would be preferred. Knowledge of the prevailing hypothesis and mechanisms underlying cardiovascular dysfunction in diabetes is also essential.
Additional skills include breeding and genotyping of mice, preparation of mRNA protein lysates from tissues and cells, performance of real-time PCR and Western blotting, and knowledge of the principles to be applied for RNA-sequencing analyses. Additional highly desired skills include expertise in flow cytometry and fluorescent activated cell sorting. You should be highly motivated, enthusiastic about science, learn quickly, think creatively and independently, and work efficiently. Our postdoctoral fellows train with a highly collaborative and talented group of pre- and postdoctoral research scientists.
To apply, please email your CV, a list of three suggested references, and a short statement describing your experience, goals, and reasons for your interest in this position to Ravichandran Ramasamy, PhD, at firstname.lastname@example.org.
Blood and Marrow Transplantation—February 6, 2018
NYU Langone’s Perlmutter Cancer Center is accepting applications for a postdoctoral fellowship research position in blood and marrow transplantation. This is a full-time position in the laboratory of Juan Lafaille. The successful candidate must have a PhD or MD degree and an interest in the prevention of graft-versus-host disease. Experience in flow cytometry and small animal work is preferred.
Salary and benefits are commensurate with experience. Interested applicants should forward a cover letter, current and future research interests (maximum one page), CV, and the names, telephone numbers, and email addresses of three references by email to A. Samer Al-Homsi, MD, MBA, clinical professor at NYU Langone’s Department of Medicine and director of the Blood and Marrow Transplant Program at Perlmutter Cancer Center, at email@example.com.
Genomics of Complex Cardiovascular Disease—February 1, 2018
A postdoctoral position is available immediately in the laboratory of Aravinda Chakravarti, PhD, at NYU Langone’s new Center for Human Genetics and Genomics, which is in relation to the Institute for Systems Genetics.
Our laboratory focuses on the formulation, development, and application of genetic, genomic, and computational technologies and perspectives for the discovery of genes and mechanisms in a variety of complex (non-Mendelian) human diseases, specifically cardiovascular diseases such as hypertension and sudden cardiac death. Our overall goals are to develop a paradigm for the genetics of common disease and to assess how genomic information can be used in modern clinical medicine in the era of personalized medicine.
The successful candidate will research the genetics and genomics of complex phenotypes, specifically blood pressure regulation. The candidate will work on human genome sequence data from subjects of a large epidemiological cohort study to analyze the contributions of different genes and tissues contributing to interindividual variation in blood pressure, and therefore, risk of hypertension.
The ideal candidate holds a PhD and/or an MD in human genetics, biostatistics, or other biomedical-related fields. Candidates must have a solid background in one or more of the following fields: genetics, computational biology, or biostatistics. We are looking for a creative and driven individual with a strong publication record and advanced expertise in software development and statistical analyses.
To apply or to obtain more information about the position, please contact Dr. Chakravarti at firstname.lastname@example.org. Applicants should include a CV, brief statement of research background, and the names of three references.
Platelets, Inflammation, and Cardiovascular Disease—January 23, 2018
A postdoctoral position is available in the platelet laboratory of Jeffrey S. Berger, MD, MS, at NYU Langone Health’s Leon H. Charney Division of Cardiology. Our laboratory is dedicated to elucidating the mechanism and regulation of platelet- mediated complications in atherogenesis, thrombosis, and inflammatory disease states.
Platelets are major players in the fields of thrombosis and hemostasis and inflammation and immune activation. Increased platelet activity contributes to the pathogenesis of vascular dysfunction, atherosclerosis, thrombosis, and a heightened inflammatory state. Using a combination of human transcriptional profiling studies, mouse models, and cell culture, we aim to identify novel signaling pathways in platelets that contribute to cardiovascular risk.
The postdoc conducts research to investigate novel and targetable signaling pathways in platelets. The successful candidate joins a dedicated and hardworking team determined to achieve results that change the way we treat cardiovascular disease and other inflammatory diseases.
Ideal candidates hold a PhD and/or an MD in biological sciences or biomedical-related fields and must have a solid background in one or more of the following fields: thrombosis and hemostasis, immunology, and/or genetics. We are looking for a creative and driven individual with a strong publication record and advanced expertise in molecular biology (including reverse transcription polymerase chain reaction, or RT-PCR; cloning; immunoprecipitation; and western blotting), flow cytometry, cellular imaging/microscopy, and platelet physiology. Previous experience in high-throughput sequencing, such as RNA sequencing (RNA-seq) and assay for transposase-accessible chromatin (ATAC-seq) techniques, is highly desired.
To apply or to obtain more information about the position, please contact Dr. Berger at email@example.com. Include a CV, brief statement of research background, and the names of three references.
Molecular Underpinnings of Lung Cancer—January 22, 2018
A postdoctoral position is available immediately in the laboratory of Kwok-Kin Wong, MD, PhD. The Wong Laboratory is a translational oncology laboratory at NYU Langone's Perlmutter Cancer Center. Our laboratory focuses on advancing the understanding of genetic and tumor immune alterations involved in lung tumorigenesis and pathogenesis, and have been instrumental in evolving lung cancer into a genetically stratified disease and changing how lung cancer patients are treated. Our highly collaborative laboratory has pioneered generating and utilizing genetically engineered mouse lung cancer models to validate oncogenic drivers and test novel therapeutics against specific genetic oncogenic drivers. These preclinical models are now being used to lead the next revolution in lung cancer treatment through the combined assessment of genetics and tumor immunology.
Working with leading academic clinicians and basic scientists as well as scientists from premier biotech and pharmaceutical companies, the successful candidate has the opportunity to do groundbreaking work to elucidate fundamental understanding of the molecular underpinnings of lung cancer. The successful candidate contributes to and participates in pioneering work on the interplay of genetics, tumor immune infiltrate, and therapeutics in preclinical lung cancer models with the ultimate goal of developing rational treatment hypotheses to be tested in the clinic. In addition, you have the opportunity to work with industrial partners (pharmaceutical and biotechnology) on the development of next-generation lung cancer therapies, to generate understanding of drug mechanism of actions and development of novel treatments and combinations, novel biomarkers, and identify new targets for novel therapeutics. Applicants also effectively communicate their work by writing manuscripts and successfully publishing their results in journals.
Applicants must have a PhD degree in cancer biology, immunology, or biological sciences and experience with molecular biology, genomic analysis, and biochemistry and cell biology. Both in vivo pharmacology experience and immunology experience is a plus. You must also have demonstrated scientific rigor and excellence, and technical excellence.
We are seeking a self-motivated and innovative candidate who can work independently and possess strong work ethic and organizational skills. Additionally, you have an outstanding publication record; excellent written, oral, and interpersonal communication skills; and an ability to work productively and constructively in a team environment. In short, you are able to excel in a goal-oriented, multifaceted, and fast-moving environment.
Interested candidates should email Christina Almonte at firstname.lastname@example.org.
Tissue Regeneration and Translational Medicine—January 3, 2018
A postdoctoral position is available immediately in the laboratory of Leslie I. Gold, PhD, at NYU Langone’s Departments of Medicine and Pathology. The Gold Laboratory discovered that calreticulin, the calcium-binding endoplasmic reticulum chaperone protein, has profound positive biological effects on wound repair and tissue regeneration, creating an exciting new research field. Wounds heal with regrowth of hair follicles and without scarring. In vitro, calreticulin has been shown to effect migration of cells into a wound, proliferation of cells to populate the wound for remodeling, the production of extracellular matrix proteins to fill in the wound defect, removal of dead cells for wound debridement, and prevention of infection.
Studies are underway to understand the mechanisms and pathways involved in these novel extracellular functions of calreticulin, and the structure and functional relationships of the molecule. We are seeking a postdoctoral researcher who is interested in this area of research and prefer candidates who demonstrate the ability to be creative, are highly motivated, can work independently, and possess a background in tissue culture, cell biology and general molecular biology, and biochemical techniques including migration and phagocytosis assays.
This position is an excellent and exciting opportunity for exposure to all aspects of translational medicine (patent law, formulation, pharmacodynamics and toxicology, clinical trials, FDA regulations) while continuing to explore the basic science mechanisms related to the novel functions of calreticulin. We provide a highly enriched and interactive basic science environment.
If you are interested in this position, please send your CV and at least three references to Dr. Gold at email@example.com.
Translational Cancer and Leukemia Research—January 3, 2018
The Translational Cancer and Leukemia Research Laboratory in NYU Langone’s Division of Hematology and Medical Oncology, NYU Langone’s Perlmutter Cancer Center, and NYU School of Medicine invites PhD-trained postdoctoral applications. The laboratory focuses on the molecular-genomic characterization of primary AML, MDS, and MPNs in correlation to their response to commonly used therapies, in particular elucidating mechanisms of response and resistance to clinically used drugs in patients. We also focus on mechanistically understanding genomic findings and to validate molecular vulnerabilities as sites for rational therapeutic interventions. Ultimately novel therapies and diagnostic approaches will be developed and directly translated into clinical application; several therapeutic concepts developed in the laboratory were already translated into clinical studies.
Currently available projects include the following:
- DNA damage response and repair; specifically understanding the mechanisms of the anti-leukemic activity of WEE1 and CHEK1 inhibition
- characterizing epigenetic/hypomethylating agent resistance and design of rational combinations
- novel therapeutic approaches for myeloproliferative neoplasm
The postdoctoral positions offer a unique opportunity to engage in and be part of the development of a newly built program at NYU Langone and the Perlmutter Cancer Center. As such, strong dedication and independence are required with the chance of gaining deep insights into state-of-the-art translational cancer research and genomic-molecularly based personalized medicine. We offer a scientifically stimulating environment, with extensive resources and opportunities to collaborate within NYU Langone and externally.
Applicants are expected to have a strong background in molecular biology and cancer research, preferably in hematological malignancies and/or leukemia, and be proficient in most molecular biology methods. You should have obtained a PhD degree with excellent results, be detail oriented, and have good record-keeping and oral and written communication skills. You must be able to work independently in a fast-paced, dynamic research environment. All projects will involve mouse models and work on primary human specimens from patients and trials.
In addition, applicants are expected to participate in general laboratory maintenance. Manuscript writing, contributing to grant applications, and potentially participating in the mentoring of PhD/MD students are part of the postdoctoral experience.
You will have close interaction with the primary investigator and be actively involved in all aspects of the Translational Leukemia Program and early drug development, with access to the latest investigational anticancer drugs and developments. The laboratory is funded by several agencies, including the National Cancer Institute, Leukemia and Lymphoma Society, and American Society of Clinical Oncology, and at the institutional level.
Applicants should send a letter of motivation in English, one to two pages; a CV; and a list of publications with the two most important ones marked. Please also provide the names of two to three potential referees as a single combined pdf file by email to Raoul Tibes, MD, PhD, at firstname.lastname@example.org.
Mechanisms and Treatment of Anxiety, Trauma, and Grief-Related Disorders—December 13, 2017
Our mission is to improve understanding and treatment of anxiety- and fear-related disorders and complicated grief through clinical investigation and treatment studies. We aim to leverage the exponential growth in real-time advances in genetics, neurobiology, molecular biology, pharmacotherapy, and psychology to better understand key factors that lead to the development and persistence of anxiety and grief disorders, as well as their optimal treatment.
The fellowship is designed to provide comprehensive training in research investigation and clinical care in anxiety, grief, and fear-based disorders, including complicated grief, panic disorder, social anxiety disorder, generalized anxiety disorder, and post-traumatic stress disorder. Ongoing studies at various stages of recruitment and data analysis include clinical trials of pharmacotherapy, cognitive behavioral therapy, and yoga, and cross-diagnostic biomarker research utilizing blood samples.
Additional areas of interest include psychophysiological assessments and fear-conditioning paradigms, emotion perception experiments, real-time patient monitoring, sleep-related studies, and collaboration with neuroimaging laboratories.
The postdoctoral fellow will have the exciting opportunity to assist in the growth of this new program and will receive close mentorship and support as he or she continues to develop a professional career in clinical psychology and clinical research.
Applicants must have a PhD degree and have completed an internship in clinical psychology by July 2018. Competitive applicants will have prior experience in relevant clinical care and/or research; a background in related psychology, neuroscience, and/or biological studies; and demonstrated interest in this line of research as exemplified by academic presentations and/or peer-review publications.
Candidates who are motivated to pursue a career in clinical research to investigate the phenomenology and treatment of anxiety-, fear-, and/or grief-related conditions will be considered for the position and are encouraged to apply. Supervised clinical time to support training and licensure is included in the fellowship.
Interested applicants should email their cover letter and CV to Dr. Simon at email@example.com and program coordinator Rebecca Lubin at firstname.lastname@example.org by February 1, 2018. We are accepting applications on a rolling basis.
Cancer Immunology, Imaging, Biophysics, and Structural Biology—December 11, 2017
A postdoctoral position is available immediately in the laboratory of Michelle Krogsgaard, PhD, at NYU Langone’s Department of Pathology and Perlmutter Cancer Center. The Krosgaard Laboratory is seeking a fellow for a project focused on manipulating T-cell immune responses to cancer while maintaining specificity to avoid autoimmunity and off-target toxicity, which is recognized as one of the most important and challenging areas for clinical cancer immunotherapy.
Our laboratory combines biophysical techniques including nuclear magnetic resonance spectroscopy, 2D affinity/force measurements, computational docking, imaging with chemical labeling, and T-cell functional studies to provide an overall signaling model involving the T-cell receptor and CD3 complex (TCR–CD3) and associated proteins to better understand the molecular basis for transmitting activating signals in T cells.
Identifying the molecular determinants of TCR–CD3 and other associated kinase interactions involved in the initiation of T-cell signaling forms the basis for designing novel therapeutics (synthetic T-cell receptors, chimeric antigen receptors, antibodies, or small molecules) that strengthen or weaken these interactions and target specific disease conditions.
Candidates must have a recent PhD in biology, molecular biophysics, or a related area. Experience in basic cellular immunology, molecular biology, structural and biophysical methods protein expression, tissue culture, in vivo mouse models, and flow cytometry is advantageous but not required.
The successful candidate is expected to be detail-oriented, highly organized, able to multitask, take initiative, and start and complete projects. He or she must be flexible and able to function in a fast-paced, changing work environment, with a variety of people from different backgrounds. The candidate must also be comfortable working with computers and proficient in Microsoft Office, PowerPoint, and Excel.
The Krosgaard Laboratory is located in Smilow Research Center, a new building with excellent research facilities on the NYU Langone campus in midtown Manhattan.
Salary and benefits are commensurate with experience. Interested applicants should forward a cover letter; current and future research interests (maximum one page); curriculum vitae; and the names, telephone numbers, and email addresses of three references to Dr. Krogsgaard at email@example.com.
RNA-Protein Complexes and Non-coding RNA—November 8, 2017
A postdoctoral position is available immediately in the laboratory of Alexander Serganov at NYU Langone’s Department of Biochemistry and Molecular Pharmacology. The Serganov Laboratory is looking for a talented self-motivated postdoctoral scientist with a proven academic track record and a strong interest in cutting-edge interdisciplinary research.
The group studies the application of genome-wide techniques, biochemical methods, X-ray crystallography, and cryo-electron microscopy (cryo-EM) to answer fundamental questions about gene expression control by RNA-protein complexes and noncoding RNAs in prokaryotes and eukaryotes. Research topics include transcriptional and translational control, mRNA modification, and RNA degradation. The postdoc will primarily focus on RNA-mediated regulation of gene expression in mammals and the impact of RNA-protein complexes on the development of human diseases.
The candidate should hold a PhD or be a PhD candidate in structural biology, biochemistry, molecular biology, or related fields. Qualified candidates should have a strong background in routine molecular biology techniques and protein purification. Experience in X-ray crystallography, cryo-EM, and RNA research is highly desirable.
The successful candidate is expected to take a strong lead on the project and develop independent ideas. Demonstrated ability to work effectively in a collaborative multidisciplinary environment is necessary. Strong record keeping, good work ethic, and initiative are essential. Good communication in English is expected.
Interested applicants should submit a detailed CV, a brief statement of research interests describing previous research experiences, and the names and contact information (email addresses and telephone numbers) of three references to Dr. Alexander Serganov at firstname.lastname@example.org.
Consideration of submitted applications will start immediately and continue until the position is filled. We provide a stimulating scientific atmosphere, collaboration with leading groups, a competitive salary, excellent benefits, and subsidized housing.
Adult and Pediatric Cognitive Impairment and the Use of Transcranial Direct Current Stimulation (tDCS)—October 30, 2017
A postdoctoral position is available at the Multiple Sclerosis Comprehensive Care Center at NYU Langone’s Ambulatory Care Center. In addition to providing patient care, our team of multiple sclerosis (MS) experts is at the forefront of research into new treatments for MS including therapies that improve function and end the disease.
We are seeking a motivated and creative postdoctoral researcher who is interested in overseeing ongoing research studies in the areas of adult and pediatric cognitive impairment and the use of transcranial direct current stimulation (tDCS). Other projects include managing and analyzing a large clinical database and assisting with manuscript and grant writing.
Candidates should have advanced knowledge of database management and statistics, including REDCap web application, SPSS software, and R software, and advanced writing skills and experience with publications and grant submissions.
Familiarity with cognitive assessment and clinical research and experience working with patients who have neurologic or psychiatric disease is also required. Candidates who are familiar with neuromodulation research are especially encouraged to apply.
Please send a cover letter explaining relevant work experience and interests, a CV, and the contact information of three references to Leigh E. Charvet, PhD, at email@example.com and copy Nicole Mahaffey at firstname.lastname@example.org.
The Role of TGF Beta and Inflammation in Aneurysm Production—October 1, 2017
A postdoctoral position is available immediately in the laboratory of Daniel Rifkin, MD, at NYU Langone’s Department of Cell Biology. The Rifkin Laboratory is seeking an ambitious and motivated PhD to investigate the role of TGF beta and inflammation in the pathogenesis of thoracic aneurysms.
In animals and humans, a number of mutations of proteins of the extracellular matrix (ECM) result in dilation and eventual rupture of the thoracic aorta. The most common of these conditions is Marfan syndrome, an autosomal dominant condition caused by mutations in the gene for fibrillin-1, a large multidomain, ubiquitous ECM protein. The one other known protein group in the fibrillin family are the latent transforming growth factor beta (TGFβ) binding proteins (LTBP).
As the name implies, the LTBPs bind TGFβ. The fact that fibrillin-1 binds to LTBP-1 led to the suggestion that abnormalities in fibrillin-1 might affect TGFβ function. Indeed, lowering TGFβ levels in Marfan syndrome mice decreases the severity of aortic aneurysms. We have found that loss of LTBP-3 in Marfan mice also prevents dilation and protects against rupture. Additionally, the loss of Rag2 in Marfan mice blocks rupture but does not inhibit dilation.
Our current research is focused on the molecular role of LTBP-3 in aneurysm production, the role of the immune system in vessel rupture, and early and late contributions of LTBPs and TGFβ to blood vessel physiology.
We are currently using mouse genetics, as well as cell, molecular, and genomic approaches to identify unique molecular targets of TGFβ, as well as immune-dependent lytic reactions. We also use cell culture methods to examine the effect of permuting specific TGFβ-related proteins of the physiology on vascular smooth muscle cells derived from our mouse models.
Candidates should have experience with mouse breeding, cell biology and/or biochemistry.
Our laboratory is located on the NYU Langone campus at 31st Street and First Avenue in midtown Manhattan. We collaborate with several groups within NYU School of Medicine as well as groups at Mt. Sinai School of Medicine and Yale University Medical School. We provide an exciting and stimulating scientific atmosphere with emphasis on the mechanistic and translational aspects of growth factor, matrix, and vascular biology. We provide a competitive salary and excellent benefits.
Applicants should send a CV, a letter describing research experience and career goals, the names and contact information for three individuals who can serve as references, and expected date of availability to Dr. Daniel Rifkin at email@example.com.
Ion Channels in Immunity to Infection, Tumors, and Autoimmunity—September 21, 2017
A postdoctoral position is available in the laboratory of Stefan Feske, MD, at NYU Langone’s Experimental Pathology Program. The Feske Lab has long-standing expertise in investigating calcium signaling pathways in cells of the immune system. We study the molecular regulation of calcium release-activated channels (CRAC) formed by ORAI and stromal interaction molecule (STIM) proteins and investigate their role in the physiology of immune and other cells.
We use mice with targeted deletion of CRAC channels and human patients with mutations in CRAC channel genes to investigate how calcium signals control immune responses to infection and tumors, and in autoimmunity and inflammation (e.g., multiple sclerosis and colitis). Other ion channels also regulate T cell-mediated immunity to pathogens, tumors, and self. The Feske Lab is characterizing ion channels that control these immune responses.
We are seeking motivated and creative postdoctoral researchers who have recently earned a PhD or MD/PhD and who are interested in pursuing projects in the area of ion channels in immunity and inflammation. We are part of the world-class immunology research community at NYU Langone Health and its Perlmutter Cancer Center. Our research is published in leading journals including Nature, New England Journal of Medicine, Immunity, Nature Immunology, Nature Communications, The Journal of Experimental Medicine, The Journal of Clinical Investigation, and Proceedings of the National Academy of Sciences.
Candidates should have a strong background in T cell function that includes experience in analyzing T cell-mediated immune responses in vivo using mouse models. Candidates with experience in ion channel function in immune cells or other cell types are especially encouraged to apply. A background in molecular and cell biology, including recombinant DNA technology, is desired. Please send a cover letter explaining relevant work experience and interests, a CV, and the contact information of three references to Dr. Feske at firstname.lastname@example.org.
Cell Fate Determination and Synapse Formation—September 19, 2017
A postdoctoral position is available in the laboratory of Jessica E. Treisman, PhD, at NYU Langone’s Skirball Institute of Biomolecular Medicine. The Treisman Lab uses the visual system of Drosophila, a type of fruit fly, as a model to understand how cell–cell signaling and intrinsic transcriptional networks drive cells in the nervous system to adopt different fates, and how these neurons then identify the correct synaptic partners and assemble functional circuits.
We are seeking a motivated and creative postdoctoral researcher who is interested in pursuing a project related to these topics. The Skirball Institute of Biomolecular Medicine offers a highly collaborative research environment located in the heart of New York City.
Candidates should have recently obtained or be about to obtain a PhD in a field of biological science and should have a strong publication record. Experience in genetics, molecular biology, biochemistry, and cell culture and/or imaging would be an advantage. Please send a CV, statement of research interests, and contact information for three references to Dr. Treisman at email@example.com.
Secretion of Exosomes, a Neuroprotective Mechanism in Alzheimer’s Disease—September 8, 2017
Postdoctoral positions are available immediately in the laboratory of Efrat Levy, PhD, for outstanding, highly motivated postdoctoral research fellows to play a major role in state-of-the-science integrative studies of Alzheimer’s disease and related neurodegenerative conditions.
The projects for these positions focus on the following:
(a) defining the mechanisms regulating exosome generation, secretion, and their content, and to test the hypothesis that pathogenic alterations of the endosomal/lysosomal pathway in Alzheimer’s disease disrupt brain exosome release. Furthermore, this study aims to demonstrate that restoring normal exosome production may be an innovative therapeutic approach for reducing endosomal/lysosomal pathway pathology in Alzheimer’s disease.
(b) Studying our hypothesis that the interaction between the Italian amyloid beta, which contains an amino acid substitution at residue 2 of amyloid beta, and wild-type amyloid beta hinders amyloid beta oligomerization, amyloidogenesis and neurotoxicity, and investigate the mechanism(s) by which Italian amyloid beta is protective. The proposed research will develop exosomes as vehicles to deliver protective Italian amyloid beta within the brain, a novel therapeutic approach for Alzheimer’s disease.
These studies routinely employ multidisciplinary approaches including behavioral tests of mouse models, mouse and human postmortem immunohistochemistry, biochemical analyses, including Western blot and ELISA, and in vitro models of Alzheimer’s disease.
Dr. Levy’s laboratory is located at the Center for Dementia Research at Nathan S. Kline Institute, an affiliate of NYU School of Medicine. The institute is a world-renowned facility for research on Alzheimer’s disease and other neurodegenerative disorders situated close to New York City, providing a unique research and training opportunity to combine molecular, morphologic, and in vitro and in vivo approaches in a multidisciplinary setting.
Applicants must have a recent PhD or the equivalent and must have a strong research background as evidenced by peer-reviewed publications in international journals.
To apply, please send a full CV, a brief statement of current research and long-term goal, and names and contact information of three references to Dr. Levy at firstname.lastname@example.org.