Available Positions for Postdoctoral Fellows
At NYU School of Medicine, we frequently post new opportunities for postdoctoral fellows to join our team of world-class biomedical investigators.
If you are interested in applying for an available position, please contact the principal investigator directly using the contact information included with the position listing. You might find additional postdoc opportunities by searching the NYU School of Medicine website for a researcher or department that interests you. There may be additional research opportunities available.
NYU School of Medicine researchers who have an available postdoctoral position they would like to add to this list can submit the new postdoctoral position submission form.
Current postdocs nearing the end of their appointment can log into the postdoc community using their Kerberos ID to browse a list of job openings. Faculty and administrators from outside institutions who wish to add a job opening to this list can do so by submitting a career opportunity form.
Current Postdoctoral Openings
NYU School of Medicine is an equal opportunity employer committed to fostering diversity for postdoctoral fellows in the workplace. The following positions offer competitive salaries, excellent benefits, and eligibility for student housing.
Stress Response Pathways in Drosophila—November 6, 2018
The laboratory of Hyung Don Ryoo, PhD, has a position available for a researcher at the pre- or postdoctoral level. Our laboratory has focused on the use of Drosophila to study the role of specific stress response pathways in age-related retinal degeneration, lifespan, and general development. One particular pathway of interest is that mediated by ATF4, a transcription factor that is activated by unfolded protein overload in the endoplasmic reticulum or in response to amino acid deprivation. In recent years, we have developed new tools to study this pathway in Drosophila and found that it plays an important role in extending lifespan, delaying retinal degeneration, and mounting an anti-bacterial innate immune response (see Kang and colleagues in Journal of Cell Biology and Vasudevan and colleagues in Cell Reports). Intriguingly, ATF4 mRNA translation is stimulated specifically under stress conditions that reduce general mRNA translation due to a unique regulatory 5’ untranslated region.
The Ryoo Lab is interested in identifying new regulators of this process and to investigate how the pathway affects innate immune response and general stress resistance. In addition to the classical genetic techniques, our laboratory plans to employ cutting-edge genomic technologies for this work.
Interested candidates should send a CV to Dr. Ryoo at firstname.lastname@example.org.
Urothelial Differentiation and Stem Cells—November 6, 2018
A postdoctoral position is available in the joint team of Xue-Ru Wu, MD, and Tung-Tien Sun, PhD, to study the differentiation and stem cells of the urothelium. Diseases involving the urothelium include urinary tract infection and bladder cancer, which are among the most common human conditions.
Our team has a long-standing interest in studying epithelial differentiation and stem cells, having contributed to the identification of keratins as epithelial markers, the identification of corneal and follicular epithelial stem cells, and the discovery of uroplakins—which are major urothelial differentiation products that form 2D crystals covering the urothelial apical surface. Our current projects study the structure, function, and disease implications of uroplakins and the mechanisms of urinary tract infection and bladder tumorigenesis. For more information, see the Wu Lab and the Sun Lab.
We are looking for an ambitious postdoc to join our team. The candidate will preferably have a PhD degree related to biochemistry or cell and molecular biology and enjoy independent research. Please send your CV and the contact information for three references to Dr. Wu at email@example.com and/or Dr. Sun at firstname.lastname@example.org.
Tissue Regeneration and Translational Medicine—October 25, 2018
A postdoctoral position is available immediately in the laboratory of Leslie I. Gold, PhD, in NYU Langone’s Division of Translational Medicine. Our laboratory discovered that the calcium-binding endoplasmic reticulum chaperone protein, calreticulin (CRT), has profound positive biological effects on wound repair and tissue regeneration, which opens up an exciting new research field. Topical application of CRT heals wounds by tissue regeneration showing epidermal appendage neogenesis, such as hair follicles, without scarring. In vitro, CRT induces migration of cells to resurface the wound, proliferation of cells to populate the wound, the production of extracellular matrix proteins to remodel and reconstruct the wound defect, removal of dead cells for wound debridement, and prevention of infection. Studies are underway to understand the mechanisms and pathways involved in these novel extracellular functions of CRT, as well as structure–function relationships of the molecule.
We are seeking candidates who are creative and highly motivated and who possess the ability to work independently. Candidates with a strong background in tissue culture, cell biology, and general molecular biology and biochemical techniques, including migration assays, are preferred. This position is an excellent and exciting opportunity for you to gain exposure to all aspects of translational medicine (patent law, formulation, pharmacodynamics and toxicology, clinical trials, and FDA regulations) while continuing to explore the basic science mechanisms related to the novel functions of calreticulin. We offer an enriching and interactive basic science environment and special postdoctoral programs for independent growth. Please send your CV and at least three references to Dr. Gold at email@example.com.
Laryngology, Voice, and Swallowing—October 17, 2018
The laboratory of Ryan C. Branski, PhD is looking for postdoctoral candidates with a strong background in cell and molecular biology, who are broadly interested in research related to voice, swallowing, and airway disorders. Ideal candidates will have one to two years of laboratory experience with both animal models and cell culture techniques.
Our laboratory investigates new approaches to restoring function and improving quality of life for people with voice and speech disorders caused by aging, tumors, and vocal scarring. We currently have multiple grants for the National Institutes of Health to investigate the potential therapeutic effects of RNA-based therapeutics on tissue repair, the role of glucocorticoids on tissue health and response to injury, and a novel tissue engineering approach to address altered wound healing.
By leveraging the abundant clinical resources available at NYU Langone Health, we are uniquely able to translate our benchside research findings to improve the diagnosis and treatment of voice, speech, and swallowing disorders.
To apply, please send a cover letter describing your scientific interests and their potential resonance with our research, a CV, and two to three letters of recommendation to Dr. Branski at firstname.lastname@example.org.
Liver Cancer Research—October 17, 2018
The Welling Laboratory in Liver Cancer Research invites post-doctoral candidates to apply to the laboratory of Theodore H. Welling, MD, director of the Liver Tumor Program at NYU Langone’s Perlmutter Cancer Center.
Our laboratory focuses on the interplay between the tumor immunology microenvironment and tumor biologic processes, such as epithelial to mesenchymal transitions and stemness function in liver cancer.
Projects include the identification of mechanisms by which tumor associated macrophages (TAMs) promote hepatocellular carcinoma and cholangiocarcinoma progression. The preclinical evaluation of novel therapeutics designed to disrupt these mechanisms is another key project.
Our work spans basic discovery, preclinical modeling, and translational studies coupled with novel therapeutics. The Welling Laboratory is highly collaborative and works with many premier investigators in academia and the pharmaceutical industry. The lab is funded by institutional, Department of Defense, and private funds.
We are seeking candidates with strong dedication and independence, who are able to effectively communicate their work by publishing the results in premier journals. The postdoc will be involved in grant writing with an opportunity to submit their own career awards. We offer a scientifically stimulating environment with extensive resources and opportunities to collaborate within NYU Langone and externally.
Applicants must have the following qualifications:
- be a recent PhD graduate in immune-oncology, cancer biology, molecular biology, or relevant field
- have experience with molecular biology, genomic analysis, biochemistry and cell biology, in-vivo pharmacology, immunology, multiflow cytometry, cell culture
- experience with in-vivo syngeneic mouse tumor models and experience with 3D cell culture is preferred but not required
- experience in the isolation and characterization of immune cells from primary human and mouse tissues
- be able to demonstrate scientific rigor, scientific excellence, and technical excellence
- be independent, self-motivated, and innovative
- be able to present a publication record
- have excellent written and oral communication skills
- be willing to seek out grant funding from external sources and participate in writing grant proposals
- have outstanding interpersonal skills, strong work ethic, and organizational skills
- have the ability to work productively and constructively in a team environment
To apply, please send a cover letter including a statement of research interest, full CV, and contact information for three references to email@example.com.
Genomics of Developmental Disorders—October 15, 2018
The Chakravarti Lab focuses on investigating and modeling the molecular genetic basis of human disease, running the gamut from Mendelian to oligogenic to complex, using experimental, quantitative, and animal model approaches. A major project is on the genetic and functional dissection of Hirschsprung’s disease (HSCR), a multifactorial disorder of the enteric nervous system resulting from failure of intestinal innervation. We are interested in discovering the susceptibility genes and the cellular and developmental mechanisms leading to HSCR. We use genomic data from human patients and subjects, together with animal and cellular models of these disorders, to infer the genetic characteristics of complex inheritance and assess the role of gene regulatory networks in human disease.
The ideal candidate holds a PhD and/or an MD in genetics, molecular biology, or developmental biology and has some experience in computation; knowledge of human genetics is a plus. We are looking for a creative individual with a strong publication record and advanced expertise in experimental studies.
To apply or to obtain more information about the position, please contact Dr. Chakravarti at firstname.lastname@example.org. Applicants should include a CV, a one-page research statement, and the names of three references.
Division of Epidemiology—September 27, 2018
The fellowship will focus on mentored, applied research on the nature and prevention of substance abuse from a public health perspective. Although the specific content of the fellowship will be tailored to meet the goals of the fellow, particular emphasis will be placed on conducting research that examines the social and policy determinants of opioid use, abuse, and overdose, as well as the impact that opioid-related harm may have on the health of local populations.
The fellow will participate in ongoing research and design and lead studies of their own, with mentoring from Magdalena Cerdá, DrPh, and faculty from a wide variety of fields.
Specific opportunities exist to participate in studies that examine:
- the impact that laws and policies aimed at regulating the opioid supply have on prescribing, opioid misuse, opioid disorder, and overdose
- the synergistic and independent impact of opioid laws and policies and marijuana legalization on prescribing practices and opioid-related harm
- the impact of marijuana legalization on marijuana use and other types of substance use in Latin America
The fellow will also have the opportunity to initiate new projects and develop grant proposals.
The fellowship takes place within the newly created NYU Langone Center on Opioid Epidemiology and Policy, part of the Department of Population Health. Our faculty members conduct new research on the social determinants of substance use, the impact of state and national policies on substance use, and the effects of different treatment regimens and medications on substance use disorders.
Outstanding training opportunities for multidisciplinary research in substance use epidemiology are available within the department. Our divisions include epidemiology, biostatistics, healthcare delivery science, medical ethics, health and behavior, and comparative effectiveness and decision science.
Multidisciplinary research on substance use is also fostered through collaboration with NYU Rory Meyers College of Nursing’s Center for Drug Use and HIV Research, a National Institutes of Health-funded center that focuses on public health issues related to HIV, hepatitis C, and drug use. State-of-the-art research resources, including extensive biostatistical and bioinformatics support, are available.
Candidates must have a doctorate in epidemiology or an equivalent degree and have excellent qualifications in and demonstrated commitment to epidemiologic research. Experience in substance use epidemiology, particularly with opioids, is preferred.
Qualified applicants should email a cover letter describing their research experience and interest in this fellowship, a CV, and the names and contact information for three references to Elizabeth Clancy, program manager, at email@example.com.
Host–Microbe Interactions in Immunity and Regeneration—August 20, 2018
The laboratory of Shruti Naik, PhD, is looking for postdoctoral candidates with a strong background in molecular immunology, microbiology, and/or skin biology who are broadly interested in inflammation and tissue regeneration and/or host–microbe interactions.
Our laboratory is studying the dynamic interactions between immune cells, epithelial cells, and microbes in barrier tissues that interface with the environment. Drawing from the fields of immunology, microbiology, and stem cell biology, we use an interdisciplinary approach to mechanistically understand the factors that dictate barrier tissue fitness and function. By leveraging the abundant clinical resources available at NYU Langone Health, we are uniquely able to translate our benchside findings to gain a better understanding of human immunity and its role in health and disease.
To apply, please email Dr. Naik at firstname.lastname@example.org with the following documents:
- a cover letter describing your scientific interests and their potential resonance with our research
- a CV
- three letters of recommendation sent directly to Dr. Naik
Neurovascular Dysfunction and Alzheimer’s Disease—August 20, 2018
The laboratory of Silvia Fossati, PhD, has a position available for a postdoctoral fellow. This laboratory is part of NYU Langone’s Department of Psychiatry and the Center for Cognitive Neurology in the Department of Neurology.
Our laboratory has worked on elucidating the role of neurovascular dysfunction and mitochondria-mediated cell death mechanisms in Alzheimer’s disease, with an aim to develop possible therapeutic strategies. We are interested in candidates with skills in molecular and cell biology, as well as transgenic animal studies in Alzheimer’s disease and related disorders, including treatment, behavior, and immunohistochemical and biochemical analysis.
We are seeking a motivated, enthusiastic PhD graduate who has a broad background in the areas described. Specifically, the fellow will investigate the synergistic role of cardiovascular risk factors and amyloidosis on the molecular mechanisms of brain endothelial and neurovascular degeneration. The effective date of appointment would be September 1, 2018, or later.
Requirements of this position include the following:
- a recent PhD graduate with experience and publications in the field of Alzheimer’s disease and/or other neurodegenerative diseases (e.g., stroke)
- knowledge of molecular and cell biology, mouse studies, immunohistochemistry, and biochemistry. A good knowledge of general neuroscience and Alzheimer’s disease is preferred.
- experience with scientific writing and publication
The successful candidate is a self-motivated and driven individual who is able to exhibit exceptional research productivity and take responsibility for independent management of the project. We are seeking a detail-oriented researcher who thinks critically to effectively design experiments and solve complex research problems, possesses the ability to work in a team and interact with students who need instruction, and is a collaborative, hands-on individual who proactively shares knowledge and expertise with laboratory members. Excellent written and oral communication skills, with the ability to prepare manuscripts and presentations and to assist with grant applications, are critical.
Qualified applicants should provide a cover letter outlining their research experience and interests, a CV, and the names and address of three references addressed to Dr. Fossati at email@example.com.
Ion Channels in Immunity to Infection, Tumors, and Autoimmunity—August 10, 2018
A postdoctoral position is available in the laboratory of Stefan Feske, MD, at NYU Langone’s Experimental Pathology Program. The Feske Lab has long-standing expertise in investigating calcium signaling pathways in cells of the immune system. We study the molecular regulation of calcium release-activated channels (CRAC) formed by ORAI and stromal interaction molecule (STIM) proteins and investigate their role in the physiology of immune and other cells.
We use mice with targeted deletion of CRAC channels and human patients with mutations in CRAC channel genes to investigate how calcium signals control immune responses to infection and tumors, and in autoimmunity and inflammation (e.g., multiple sclerosis and colitis). Other ion channels also regulate T cell-mediated immunity to pathogens, tumors, and self. The Feske Lab is characterizing ion channels that control these immune responses.
We are seeking motivated and creative postdoctoral researchers who have recently earned a PhD or MD/PhD and who are interested in pursuing projects in the area of ion channels in immunity and inflammation. We are part of the world-class immunology research community at NYU Langone Health and its Perlmutter Cancer Center. Our research is published in leading journals including Nature, New England Journal of Medicine, Immunity, Nature Immunology, Nature Communications, The Journal of Experimental Medicine, The Journal of Clinical Investigation, and Proceedings of the National Academy of Sciences.
Candidates should have a strong background in T cell function that includes experience in analyzing T cell-mediated immune responses in vivo using mouse models. Candidates with experience in ion channel function in immune cells or other cell types are especially encouraged to apply. A background in molecular and cell biology, including recombinant DNA technology, is desired. Please send a cover letter explaining relevant work experience and interests, a CV, and the contact information of three references to Dr. Feske at firstname.lastname@example.org.
Cardiovascular Disease, Diabetes, and Lipid Metabolism—July 23, 2018
NYU Langone’s Division of Endocrinology, Diabetes, and Metabolism is recruiting a postdoctoral fellow to work in the laboratory of Ira J. Goldberg, MD.
Lipid uptake, inflammation, and angiogenesis are modulated by cluster of differentiation (CD) 36. The postdoc will work on a project funded by the National Heart, Lung, and Blood Institute of the National Institutes of Health to assess how CD36 deficiency in either cardiomyocytes or endothelial cells affects the response to ischemia. Previous experience in studies of cardiovascular function and/or lipid metabolism is desirable, but not required. Evidence of successful completion of research projects and publications is required.
Send your CV and references to Victoria Brown, division administrator, at email@example.com.
Translational Research in Ovarian and Endometrial Cancers—July 23, 2018
A postdoctoral research fellow or research scientist position is available in the Gynecology Research Laboratory of Douglas A. Levine, MD. We are recruiting ambitious, enthusiastic, and highly motivated individuals to join our laboratory group addressing critical problems in common and rare gynecologic cancers. The focus of our laboratory is on translational research related to ovarian and endometrial cancers.
The ideal candidate possesses a background and track record in molecular biology and has experience working with colleagues at all levels of training and ability, from postdoctoral fellows to clinical fellows and research scientists. The position includes independent work and supervision of other laboratory members. A senior postdoctoral fellow would have the opportunity to transition into a senior research scientist based on performance and productivity. Someone looking to transition from a basic science environment to a translational laboratory would be welcomed.
Applicants should hold a PhD degree and have strong laboratory, writing, and analytical skills. Significant experience in molecular biology and cancer biology is required. Good communication and organizational skills and a strong work ethic are a must. The ability to work collaboratively and to provide innovative solutions to complex problems is important. Experience in chromatin remodeling or DNA repair is necessary.
To apply for this position or for more information, please contact Dr. Levine at firstname.lastname@example.org. Candidates should submit the following items:
- a cover letter indicating current and future research interests and expected availability date
- a CV
- a description of past research experience and accomplishments
- the names and contact information of three references
Chromatin Regulation, Transcription, and Cell Cycle—July 9, 2018
A postdoctoral position is available in the laboratory of Gregory David, PhD, to study how chromatin-based events regulate cell cycle exit, including senescence and quiescence. Our laboratory is interested in understanding how to modulate cellular proliferation in diseases such as cancer and bone marrow failure syndrome. We are using a wide range of experimental systems, including mouse models of cancer.
The fellow will have the opportunity to study the contribution of specific histone modifiers in the regulation of cell cycle exit, including hematopoietic stem cell quiescence, cancer stem cell quiescence, and/or senescence in preneoplastic lesions.
Recent PhD graduates with experience in transcription, chromatin biology, cell cycle, and/or hematopoietic stem cells who possess a record of publications can apply. Interested applicants should email Dr. David at email@example.com with a copy of their CV and scientific interests.
Glioma Epigenetics and Signaling—June 29, 2018
Two postdoctoral fellow positions are available in the laboratory of Dimitris G. Placantonakis, MD, PhD, at NYU School of Medicine. Our laboratory is interested in modeling glioma and elucidating the pathogenic mechanisms of the disease. Our ultimate goal is developing novel therapies for glioma. The cellular platforms we study include patient-derived xenograft models and human pluripotent stem cells.
The fellow will be involved in two major areas of research:
- elucidating signaling mechanisms downstream of a cell–surface receptor that plays a crucial role in glioblastoma progression and characterizing the effects of receptor activation on cancer stem cell biology
- characterizing epigenetic alterations and novel dependencies in a novel model of low-grade glioma based on the human neural stem cell platform
Qualified candidates will have a PhD or an MD/PhD degree and experience in the following areas:
- signaling and pharmacology
- epigenetics and chromatin conformation
- stem cell biology
- glioma biology
Experience with cell culture and mouse modeling is desired, but motivated candidates with other background experiences are also encouraged to apply.
The laboratory is supported by grants from the National Institutes of Health, the New York State Stem Cell Science program (NYSTEM), and private foundations. Employees benefit from a collaborative scientific environment and access to NYU Langone’s scientific cores and shared resources, as well as close affiliations with the Perlmutter Cancer Center, the Kimmel Center for Stem Cell Biology, the Neuroscience Institute, the Brain Tumor Center, and the Department of Neurosurgery. Learn more about postdoctoral training at NYU School of Medicine.
Please email a letter of interest, your CV, and a list of three references to Dr. Placantonakis at firstname.lastname@example.org.
Computational and Neurophysiological Basis of Decision-Making in Monkeys—June 12, 2018
A postdoctoral position is available in the laboratory of Paul W. Glimcher, PhD to study the computational and neurophysiological basis of decision-making in monkeys as part of an National Institutes of Health-funded project looking at canonical neural computations in value coding and their relationship to optimal choice behavior.
In the Glimcher Laboratory at the NYU Center for Neural Science, we are examine the relationship between statistical regularities in the environment and adaptive neural responses in decision-related circuits. The successful candidate will have the opportunity to develop their own research questions within this conceptual and experimental framework.
Candidates must have a PhD in neuroscience or a related field. Previous experience in neurophysiology, monkey behavior, and computational modeling is preferred. MATLAB proficiency is a plus. However, all enthusiastic, curious, and ambitious candidates with a doctoral degree are encouraged to apply.
Please submit your CV, a cover letter, and the names and contact information for three references to be considered for the position. We offer a supportive and creative equal-opportunity environment. Previous postdocs in our lab have gone on to tenured or tenure-track positions at Duke University, University of Pennsylvania, Yale University, University of Toronto, University of Sydney, Institute of Neuroscience at the Chinese Academy of Sciences, Boston College, Rutgers University, Trinity, NYU Singapore, Brown University, the Champalimaud Foundation, and the French National Center for Scientific Research.
Translational Neuroscience of Drug Addiction—June 12, 2018
A postdoctoral position is available in the laboratory of Paul W. Glimcher, PhD to study the neuroeconomics of drug addiction with an interdisciplinary team focused on understanding how opiate addiction and human decision-making interrelates.
The Glimcher Laboratory at the NYU Center for Neural Science is a well-funded pioneering research group composed of psychologists, neuroscientists, economists, and psychiatrists. We use a wide-range of techniques including hospital measures of human decision-making, functional MRI, and single-unit studies in our research.
In addition to developing an individual research program, the postdoc will participate in a recently funded National Institutes of Health clinical research study examining risk and protective factors for substance use in individuals seeking treatment for opioid addiction. The study borrows methods from neuroeconomics, clinical neuroscience, and computational psychiatry.
The successful candidate will have strong computational skills as well as experience in the study of addiction. This is an opportunity to work with large, longitudinal, multi-modal (clinical, physiological, behavioral, and imaging) datasets. You also develop original research questions within this conceptual and experimental framework under the supervision of Paul Glimcher, PhD and John Rotrosen, MD at NYU and Anna Konova, PhD at Rutgers University.
Candidates must hold a PhD, MD, or MD/PhD in psychology, neuroscience, or a related field. Previous experience working with patient populations, functional neuroimaging, and/or computational modeling is desired but not required. The ideal candidate will be enthusiastic, curious, and will have excellent organizational and interpersonal skills.
Please submit a brief letter of interest describing how your current experience, skills, and future goals align with this position; an up-to-date CV; and contact information for three references.
We offer a supportive and creative equal-opportunity environment. Previous postdocs in our lab have gone on to tenured or tenure-track positions at Duke University, University of Pennsylvania, Yale University, University of Toronto, University of Sydney, the Chinese Academy of Sciences Institute of Neuroscience, Boston College, Rutgers University, Trinity, NYU Singapore, Brown University, the Champalimaud Foundation, and the French National Center for Scientific Research.
Brain Imaging and Decision Making—June 12, 2018
A postdoctoral position is available in the laboratory of Paul W. Glimcher, PhD for candidates with expertise in MRI and functional MRI who are interested in studying the neuroeconomics of decision making and/or drug addiction with an interdisciplinary team of psychologists, neuroscientists, economists, and psychiatrists.
The Glimcher Laboratory at the NYU Center for Neural Science conducts research using techniques that include in-hospital measures of human decision-making, lab studies of behavior, functional MRI, and single unit studies in animals.
The successful candidate will have strong computational skills as well as experience in either functional MRI or the study of addiction. Experience with the study of drug addiction and/or PET are a plus.
In addition to developing an individual research program, the postdoctoral fellow can participate in a National Institutes of Health-funded clinical research study examining risk and protective factors for substance use in individuals seeking treatment for opioid addiction that borrows methods from neuroeconomics, clinical neuroscience, and computational psychiatry.
This is an opportunity to work with large, longitudinal, multi-modal (clinical, physiological, behavioral, and imaging) datasets. You also develop original research questions within this conceptual and experimental framework under the supervision of Paul Glimcher, PhD and John Rotrosen, MD at NYU and Anna Konova, PhD at Rutgers University.
Candidates must hold a PhD, MD, or MD/PhD in psychology, neuroscience, imaging, or a related field. Previous experience working with patient populations, functional neuroimaging, and PET and/or computational modeling is desired but not required. The ideal candidate will be enthusiastic, curious, and will have excellent organizational and interpersonal skills.
Please submit a brief letter of interest describing how your current experience, skills, and future goals align with this position; your CV; and contact information for three references.
Extracellular Matrix and Immunology Research—May 18, 2018
A postdoctoral position is available in the laboratory of Shukti Chakravarti, PhD, to investigate regulations of innate and adaptive immunity by the extracellular matrix (ECM).
Dr. Chakravarti’s laboratory focuses on interstitial ECM proteoglycans, lumican, fibromodulin, biglycan, and decorin. Earlier studies by our laboratory established that these proteoglycans regulate structure of collagen fibrils, corneal transparency, and connective tissue health. Our laboratory has also identified novel functions for lumican in neutrophil chemotaxis, in bacterial phagocytosis, and in signals that regulate host response to bacterial lipopolysaccharides. Mice deficient in lumican show poor clearance of infections in Pseudomonas aeruginosa ocular and lung infection models. Our studies have shown that multiple toll-like receptor functions are regulated by these ECM proteoglycans. Mice deficient in each of these ECM proteins are being used to explore their functions in host immune regulations.
Our laboratory’s long-term goals are to understand how these ECM components maintain structural integrity under homeostatic conditions and interact with immune cells during infections and autoimmunity to modulate inflammation and tissue damage.
The ideal candidate holds a PhD degree in immunology with additional training in cell biology and biochemistry. The successful candidate is self-motivated and takes the initiative to understand ocular surface immunology and ECM biology. The candidate is expected to have expertise in flow cytometry, confocal microscopy, and handling mice. This individual will investigate mechanisms by which these proteoglycans regulate antigen-presenting cell functions in bacterial and viral infections.
To apply, please send your CV, a one-page statement outlining your research interest, and the names of three references to Dr. Chakravarti at email@example.com.
Links between Mammary Development and Breast Cancer Risk—May 14, 2018
A postdoctoral position is available in the laboratory of Pamela Cowin, PhD to study the roles of an unusual adhesion G protein-coupled receptor (GPCR) during mammary development and breast cancer.
We are exploring how adhesion GPCRs control stem cell and progenitor cell dynamics and ductal extension during pubertal development in the normal mammary gland. These proteins are elevated in aggressive forms of human breast cancer, and our studies in mice suggest they may promote local invasion and breast cancer metastasis.
We have developed genetically modified mice that permit cells expressing adhesion GPCRs to be identified, harvested, molecularly characterized and tested for their regenerative abilities after transplantation. With these mice, we are able to ablate cells expressing adhesion GPCRs and test the effect of their removal on mammary development and tumor formation. We are also able to image and trace in vivo the contribution of adhesion GPCR cells to the mammary lineage. These loss- and gain-of-function analyses will define the role of these receptors within the mammary hierarchy and determine its pathological contribution to breast cancer.
Our lab has long-standing expertise in deciphering basic mechanisms of cell–cell adhesion to determine the roles of signaling pathways in embryonic and adult mammary development and in creating novel mouse models of breast cancer. We seek a postdoctoral fellow who wishes to be immersed in these fields.
We view postdoctoral training as a critical period in preparing individuals for independent careers in research. We seek a candidate who aspires to learn how to frame and answer novel scientific questions and who has the drive and desire to pioneer and take ownership of this new research area.
Our laboratory is situated within NYU Langone’s Department of Cell Biology, a community of researchers with expertise in developmental patterning and stem cell biology. Candidates must hold a PhD in a biological subject. To apply please send a CV, a cover letter, and the names and contact information of three references to Dr. Pamela Cowin at firstname.lastname@example.org.
Genomics of Cardiovascular Disease—May 4, 2018
Our laboratory focuses on the formulation, development, and application of genetic, genomic, and computational technologies and perspectives for the discovery of genes and mechanisms in a variety of complex (non-Mendelian) human diseases, specifically cardiovascular diseases. We use a variety of human patients' and subjects' genomic data, together with animal and cellular models of these disorders, to infer the genetic characteristics of complex inheritance and assess the role of gene regulatory networks in human disease. Our overall goals are to develop a paradigm for the genetics of common disease and to assess how genomic information can be used to understand disease mechanisms.
The successful candidate will research the genetics and genomics of complex cardiovascular phenotypes, specifically blood pressure regulation. The candidate will work on human genome sequence data from subjects of a large epidemiological cohort study to analyze the contributions of different genes and tissues contributing to interindividual variation in blood pressure and hypertension risk.
The ideal candidate holds a PhD and/or an MD in genetics, statistics, or the computational sciences; knowledge of human genetics is a plus. We are looking for a creative individual with a strong publication record and advanced expertise in software development and statistical analyses.
To apply or to obtain more information about the position, please contact Dr. Chakravarti at email@example.com. Applicants should include a CV, a one-page research statement, and the names of three references.