Available Positions for Postdoctoral Fellows

Postdoctoral Training Available Positions for Postdoctoral Fellows
Researcher in Lab with Pipette
Postdoctoral Training Available Positions for Postdoctoral Fellows

At NYU School of Medicine, we frequently post new opportunities for postdoctoral fellows to join our team of world-class biomedical investigators.

If you are interested in applying for an available position, please contact the principal investigator directly using the contact information included with the position listing. You might find additional postdoc opportunities by searching the NYU School of Medicine website for a researcher or department that interests you. There may be additional research opportunities available.

NYU School of Medicine researchers who have an available postdoctoral position they would like to add to this list can submit the new postdoctoral position submission form.

Current postdocs nearing the end of their appointment can log into the postdoc community using their Kerberos ID to browse a list of job openings. Faculty and administrators from outside institutions who wish to add a job opening to this list can do so by submitting a career opportunity form.

Current Postdoctoral Openings

Tissue Regeneration and Translational Medicine—January 3, 2018

A postdoctoral position is available immediately in the laboratory of Leslie I. Gold, PhD, at NYU Langone’s Departments of Medicine and Pathology. The Gold Laboratory discovered that calreticulin, the calcium-binding endoplasmic reticulum chaperone protein, has profound positive biological effects on wound repair and tissue regeneration, creating an exciting new research field. Wounds heal with regrowth of hair follicles and without scarring. In vitro, calreticulin has been shown to effect migration of cells into a wound, proliferation of cells to populate the wound for remodeling, the production of extracellular matrix proteins to fill in the wound defect, removal of dead cells for wound debridement, and prevention of infection.

Studies are underway to understand the mechanisms and pathways involved in these novel extracellular functions of calreticulin, and the structure and functional relationships of the molecule. We are seeking a postdoctoral researcher who is interested in this area of research and prefer candidates who demonstrate the ability to be creative, are highly motivated, can work independently, and possess a background in tissue culture, cell biology and general molecular biology, and biochemical techniques including migration and phagocytosis assays.

This position is an excellent and exciting opportunity for exposure to all aspects of translational medicine (patent law, formulation, pharmacodynamics and toxicology, clinical trials, FDA regulations) while continuing to explore the basic science mechanisms related to the novel functions of calreticulin. We provide a highly enriched and interactive basic science environment.

If you are interested in this position, please send your CV and at least three references to Dr. Gold at leslie.gold@nyumc.org.

Translational Cancer and Leukemia Research—January 3, 2018

The Translational Cancer and Leukemia Research Laboratory in NYU Langone’s Division of Hematology and Medical Oncology, NYU Langone’s Perlmutter Cancer Center, and NYU School of Medicine invites PhD-trained postdoctoral applications. The laboratory focuses on the molecular-genomic characterization of primary AML, MDS, and MPNs in correlation to their response to commonly used therapies, in particular elucidating mechanisms of response and resistance to clinically used drugs in patients. We also focus on mechanistically understanding genomic findings and to validate molecular vulnerabilities as sites for rational therapeutic interventions. Ultimately novel therapies and diagnostic approaches will be developed and directly translated into clinical application; several therapeutic concepts developed in the laboratory were already translated into clinical studies.

Currently available projects include the following:

  • DNA damage response and repair; specifically understanding the mechanisms of the anti-leukemic activity of WEE1 and CHEK1 inhibition
  • characterizing epigenetic/hypomethylating agent resistance and design of rational combinations
  • novel therapeutic approaches for myeloproliferative neoplasm

The postdoctoral positions offer a unique opportunity to engage in and be part of the development of a newly built program at NYU Langone and the Perlmutter Cancer Center. As such, strong dedication and independence are required with the chance of gaining deep insights into state-of-the-art translational cancer research and genomic-molecularly based personalized medicine. We offer a scientifically stimulating environment, with extensive resources and opportunities to collaborate within NYU Langone and externally.

Applicants are expected to have a strong background in molecular biology and cancer research, preferably in hematological malignancies and/or leukemia, and be proficient in most molecular biology methods. You should have obtained a PhD degree with excellent results, be detail oriented, and have good record-keeping and oral and written communication skills. You must be able to work independently in a fast-paced, dynamic research environment. All projects will involve mouse models and work on primary human specimens from patients and trials.

In addition, applicants are expected to participate in general laboratory maintenance. Manuscript writing, contributing to grant applications, and potentially participating in the mentoring of PhD/MD students are part of the postdoctoral experience.

You will have close interaction with the primary investigator and be actively involved in all aspects of the Translational Leukemia Program and early drug development, with access to the latest investigational anticancer drugs and developments. The laboratory is funded by several agencies, including the National Cancer Institute, Leukemia and Lymphoma Society, and American Society of Clinical Oncology, and at the institutional level.

Applicants should send a letter of motivation in English, one to two pages; a CV; and a list of publications with the two most important ones marked. Please also provide the names of two to three potential referees as a single combined pdf file by email to Raoul Tibes, MD, PhD, at raoul.tibes@nyumc.org.

Mechanisms and Treatment of Anxiety, Trauma, and Grief-Related Disorders—December 13, 2017

A postdoctoral fellowship in psychology is available with the Anxiety and Complicated Grief Program, a new clinical research program in NYU Langone’s Department of Psychiatry, led by Naomi Simon, MD.

Our mission is to improve understanding and treatment of anxiety- and fear-related disorders and complicated grief through clinical investigation and treatment studies. We aim to leverage the exponential growth in real-time advances in genetics, neurobiology, molecular biology, pharmacotherapy, and psychology to better understand key factors that lead to the development and persistence of anxiety and grief disorders, as well as their optimal treatment.

The fellowship is designed to provide comprehensive training in research investigation and clinical care in anxiety, grief, and fear-based disorders, including complicated grief, panic disorder, social anxiety disorder, generalized anxiety disorder, and post-traumatic stress disorder. Ongoing studies at various stages of recruitment and data analysis include clinical trials of pharmacotherapy, cognitive behavioral therapy, and yoga, and cross-diagnostic biomarker research utilizing blood samples.

Additional areas of interest include psychophysiological assessments and fear-conditioning paradigms, emotion perception experiments, real-time patient monitoring, sleep-related studies, and collaboration with neuroimaging laboratories.

The postdoctoral fellow will have the exciting opportunity to assist in the growth of this new program and will receive close mentorship and support as he or she continues to develop a professional career in clinical psychology and clinical research.

Applicants must have a PhD degree and have completed an internship in clinical psychology by July 2018. Competitive applicants will have prior experience in relevant clinical care and/or research; a background in related psychology, neuroscience, and/or biological studies; and demonstrated interest in this line of research as exemplified by academic presentations and/or peer-review publications.

Candidates who are motivated to pursue a career in clinical research to investigate the phenomenology and treatment of anxiety-, fear-, and/or grief-related conditions will be considered for the position and are encouraged to apply. Supervised clinical time to support training and licensure is included in the fellowship.

Interested applicants should email their cover letter and CV to Dr. Simon at naomi.simon@nyumc.org and program coordinator Rebecca Lubin at rebecca.lubin@nyumc.org by February 1, 2018. We are accepting applications on a rolling basis.

NYU School of Medicine is an equal opportunity employer committed to fostering diversity for postdoctoral fellows in the workplace. The following positions offer competitive salaries, excellent benefits, and eligibility for student housing.

Cancer Immunology, Imaging, Biophysics, and Structural Biology—December 11, 2017

A postdoctoral position is available immediately in the laboratory of Michelle Krogsgaard, PhD, at NYU Langone’s Department of Pathology and Perlmutter Cancer Center. The Krosgaard Laboratory is seeking a fellow for a project focused on manipulating T-cell immune responses to cancer while maintaining specificity to avoid autoimmunity and off-target toxicity, which is recognized as one of the most important and challenging areas for clinical cancer immunotherapy.

Our laboratory combines biophysical techniques including nuclear magnetic resonance spectroscopy, 2D affinity/force measurements, computational docking, imaging with chemical labeling, and T-cell functional studies to provide an overall signaling model involving the T-cell receptor and CD3 complex (TCR–CD3) and associated proteins to better understand the molecular basis for transmitting activating signals in T cells.

Identifying the molecular determinants of TCR–CD3 and other associated kinase interactions involved in the initiation of T-cell signaling forms the basis for designing novel therapeutics (synthetic T-cell receptors, chimeric antigen receptors, antibodies, or small molecules) that strengthen or weaken these interactions and target specific disease conditions.

Candidates must have a recent PhD in biology, molecular biophysics, or a related area. Experience in basic cellular immunology, molecular biology, structural and biophysical methods protein expression, tissue culture, in vivo mouse models, and flow cytometry is advantageous but not required.

The successful candidate is expected to be detail-oriented, highly organized, able to multitask, take initiative, and start and complete projects. He or she must be flexible and able to function in a fast-paced, changing work environment, with a variety of people from different backgrounds. The candidate must also be comfortable working with computers and proficient in Microsoft Office, PowerPoint, and Excel.

The Krosgaard Laboratory is located in Smilow Research Center, a new building with excellent research facilities on the NYU Langone campus in midtown Manhattan.

Salary and benefits are commensurate with experience. Interested applicants should forward a cover letter; current and future research interests (maximum one page); curriculum vitae; and the names, telephone numbers, and email addresses of three references to Dr. Krogsgaard at krogsm01@med.nyu.edu.

RNA-Protein Complexes and Non-coding RNA—November 8, 2017

A postdoctoral position is available immediately in the laboratory of Alexander Serganov at NYU Langone’s Department of Biochemistry and Molecular Pharmacology. The Serganov Laboratory is looking for a talented self-motivated postdoctoral scientist with a proven academic track record and a strong interest in cutting-edge interdisciplinary research.

The group studies the application of genome-wide techniques, biochemical methods, X-ray crystallography, and cryo-electron microscopy (cryo-EM) to answer fundamental questions about gene expression control by RNA-protein complexes and noncoding RNAs in prokaryotes and eukaryotes. Research topics include transcriptional and translational control, mRNA modification, and RNA degradation. The postdoc will primarily focus on RNA-mediated regulation of gene expression in mammals and the impact of RNA-protein complexes on the development of human diseases.

The candidate should hold a PhD or be a PhD candidate in structural biology, biochemistry, molecular biology, or related fields. Qualified candidates should have a strong background in routine molecular biology techniques and protein purification. Experience in X-ray crystallography, cryo-EM, and RNA research is highly desirable.

The successful candidate is expected to take a strong lead on the project and develop independent ideas. Demonstrated ability to work effectively in a collaborative multidisciplinary environment is necessary. Strong record keeping, good work ethic, and initiative are essential. Good communication in English is expected.

Interested applicants should submit a detailed CV, a brief statement of research interests describing previous research experiences, and the names and contact information (email addresses and telephone numbers) of three references to Dr. Alexander Serganov at alexander.serganov@nyumc.org.

Consideration of submitted applications will start immediately and continue until the position is filled. We provide a stimulating scientific atmosphere, collaboration with leading groups, a competitive salary, excellent benefits, and subsidized housing.

Adult and Pediatric Cognitive Impairment and the Use of Transcranial Direct Current Stimulation (tDCS)—October 30, 2017

A postdoctoral position is available at the Multiple Sclerosis Comprehensive Care Center at NYU Langone’s Ambulatory Care Center. In addition to providing patient care, our team of multiple sclerosis (MS) experts is at the forefront of research into new treatments for MS including therapies that improve function and end the disease.

We are seeking a motivated and creative postdoctoral researcher who is interested in overseeing ongoing research studies in the areas of adult and pediatric cognitive impairment and the use of transcranial direct current stimulation (tDCS). Other projects include managing and analyzing a large clinical database and assisting with manuscript and grant writing.

Candidates should have advanced knowledge of database management and statistics, including REDCap web application, SPSS software, and R software, and advanced writing skills and experience with publications and grant submissions.

Familiarity with cognitive assessment and clinical research and experience working with patients who have neurologic or psychiatric disease is also required. Candidates who are familiar with neuromodulation research are especially encouraged to apply.

Please send a cover letter explaining relevant work experience and interests, a CV, and the contact information of three references to Leigh E. Charvet, PhD, at leigh.charvet@nyumc.org and copy Nicole Mahaffey at nicole.mahaffey@nyumc.org.

The Role of TGF Beta and Inflammation in Aneurysm Production—October 1, 2017

A postdoctoral position is available immediately in the laboratory of Daniel Rifkin, MD, at NYU Langone’s Department of Cell Biology. The Rifkin Laboratory is seeking an ambitious and motivated PhD to investigate the role of TGF beta and inflammation in the pathogenesis of thoracic aneurysms. 

In animals and humans, a number of mutations of proteins of the extracellular matrix (ECM) result in dilation and eventual rupture of the thoracic aorta. The most common of these conditions is Marfan syndrome, an autosomal dominant condition caused by mutations in the gene for fibrillin-1, a large multidomain, ubiquitous ECM protein. The one other known protein group in the fibrillin family are the latent transforming growth factor beta (TGFβ) binding proteins (LTBP).

As the name implies, the LTBPs bind TGFβ. The fact that fibrillin-1 binds to LTBP-1 led to the suggestion that abnormalities in fibrillin-1 might affect TGFβ function. Indeed, lowering TGFβ levels in Marfan syndrome mice decreases the severity of aortic aneurysms. We have found that loss of LTBP-3 in Marfan mice also prevents dilation and protects against rupture. Additionally, the loss of Rag2 in Marfan mice blocks rupture but does not inhibit dilation.

Our current research is focused on the molecular role of LTBP-3 in aneurysm production, the role of the immune system in vessel rupture, and early and late contributions of LTBPs and TGFβ to blood vessel physiology.

We are currently using mouse genetics, as well as cell, molecular, and genomic approaches to identify unique molecular targets of TGFβ, as well as immune-dependent lytic reactions. We also use cell culture methods to examine the effect of permuting specific TGFβ-related proteins of the physiology on vascular smooth muscle cells derived from our mouse models.

Candidates should have experience with mouse breeding, cell biology and/or biochemistry.

Our laboratory is located on the NYU Langone campus at 31st Street and First Avenue in midtown Manhattan. We collaborate with several groups within NYU School of Medicine as well as groups at Mt. Sinai School of Medicine and Yale University Medical School. We provide an exciting and stimulating scientific atmosphere with emphasis on the mechanistic and translational aspects of growth factor, matrix, and vascular biology. We provide a competitive salary and excellent benefits.

Applicants should send a CV, a letter describing research experience and career goals, the names and contact information for three individuals who can serve as references, and expected date of availability to Dr. Daniel Rifkin at daniel.rifkin@nyumc.org.

Ion Channels in Immunity to Infection, Tumors, and Autoimmunity—September 21, 2017

A postdoctoral position is available in the laboratory of Stefan Feske, MD, at NYU Langone’s Experimental Pathology Program. The Feske Lab has long-standing expertise in investigating calcium signaling pathways in cells of the immune system. We study the molecular regulation of calcium release-activated channels (CRAC)  formed by ORAI and stromal interaction molecule (STIM) proteins and investigate their role in the physiology of immune and other cells.

We use mice with targeted deletion of CRAC channels and human patients with mutations in CRAC channel genes to investigate how calcium signals control immune responses to infection and tumors, and in autoimmunity and inflammation (e.g., multiple sclerosis and colitis). Other ion channels also regulate T cell-mediated immunity to pathogens, tumors, and self. The Feske Lab is characterizing ion channels that control these immune responses.

We are seeking motivated and creative postdoctoral researchers who have recently earned a PhD or MD/PhD and who are interested in pursuing projects in the area of ion channels in immunity and inflammation. We are part of the world-class immunology research community at NYU Langone Health and its Perlmutter Cancer Center. Our research is published in leading journals including Nature, New England Journal of Medicine, Immunity, Nature Immunology, Nature Communications, The Journal of Experimental Medicine, The Journal of Clinical Investigation, and Proceedings of the National Academy of Sciences.

Candidates should have a strong background in T cell function that includes experience in analyzing T cell-mediated immune responses in vivo using mouse models. Candidates with experience in ion channel function in immune cells or other cell types are especially encouraged to apply. A background in molecular and cell biology, including recombinant DNA technology, is desired. Please send a cover letter explaining relevant work experience and interests, a CV, and the contact information of three references to Dr. Feske at feskes01@nyumc.org.

Cell Fate Determination and Synapse Formation—September 19, 2017

A postdoctoral position is available in the laboratory of Jessica E. Treisman, PhD, at NYU Langone’s Skirball Institute of Biomolecular Medicine. The Treisman Lab uses the visual system of Drosophila, a type of fruit fly, as a model to understand how cell–cell signaling and intrinsic transcriptional networks drive cells in the nervous system to adopt different fates, and how these neurons then identify the correct synaptic partners and assemble functional circuits.

We are seeking a motivated and creative postdoctoral researcher who is interested in pursuing a project related to these topics. The Skirball Institute of Biomolecular Medicine offers a highly collaborative research environment located in the heart of New York City.

Candidates should have recently obtained or be about to obtain a PhD in a field of biological science and should have a strong publication record. Experience in genetics, molecular biology, biochemistry, and cell culture and/or imaging would be an advantage. Please send a CV, statement of research interests, and contact information for three references to Dr. Treisman at jessica.treisman@med.nyu.edu.

Secretion of Exosomes, a Neuroprotective Mechanism in Alzheimer’s Disease—September 8, 2017

Postdoctoral positions are available immediately in the laboratory of Efrat Levy, PhD, for outstanding, highly motivated postdoctoral research fellows to play a major role in state-of-the-science integrative studies of Alzheimer’s disease and related neurodegenerative conditions.

The projects for these positions focus on the following:

(a) defining the mechanisms regulating exosome generation, secretion, and their content, and to test the hypothesis that pathogenic alterations of the endosomal/lysosomal pathway in Alzheimer’s disease disrupt brain exosome release. Furthermore, this study aims to demonstrate that restoring normal exosome production may be an innovative therapeutic approach for reducing endosomal/lysosomal pathway pathology in Alzheimer’s disease.

(b) Studying our hypothesis that the interaction between the Italian amyloid beta, which contains an amino acid substitution at residue 2 of amyloid beta, and wild-type amyloid beta hinders amyloid beta oligomerization, amyloidogenesis and neurotoxicity, and investigate the mechanism(s) by which Italian amyloid beta is protective. The proposed research will develop exosomes as vehicles to deliver protective Italian amyloid beta within the brain, a novel therapeutic approach for Alzheimer’s disease.

These studies routinely employ multidisciplinary approaches including behavioral tests of mouse models, mouse and human postmortem immunohistochemistry, biochemical analyses, including Western blot and ELISA, and in vitro models of Alzheimer’s disease.

Dr. Levy’s laboratory is located at the Center for Dementia Research at Nathan S. Kline Institute, an affiliate of NYU School of Medicine. The institute is a world-renowned facility for research on Alzheimer’s disease and other neurodegenerative disorders situated close to New York City, providing a unique research and training opportunity to combine molecular, morphologic, and in vitro and in vivo approaches in a multidisciplinary setting.

Applicants must have a recent PhD or the equivalent and must have a strong research background as evidenced by peer-reviewed publications in international journals.

To apply, please send a full CV, a brief statement of current research and long-term goal, and names and contact information of three references to Dr. Levy at efrat.levy@nyumc.org.

Neuromodulation of Motor Skill Learning—August 22, 2017

A postdoctoral position is available immediately in the laboratory of Heidi Schambra, MD, at NYU Langone’s Department of Neurology and Department of Rehabilitation Medicine (Rusk Rehabilitation).

The Mobilis Lab aims to enhance motor recovery after stroke using targeted physical training, noninvasive brain stimulation, and neuropharmacology. We are currently studying motor skill learning in healthy individuals. We aim to manipulate neural networks in the cortex and brainstem with transcranial electrical stimulation (e.g. tDCS and cranial nerve stimulation) during learning and movement. We also seek mechanistic understanding of behavioral change using TMS neurophysiology and kinematic analysis. Eventually, we will extend our interventions to individuals with stroke undergoing quantitative training. We expect the postdoctoral fellow to lead the development of these projects.

The postdoc’s responsibilities include subject recruitment, acquiring and processing motor-learning data in human subjects, data analysis and synthesis, presenting findings at scientific meetings, writing and submitting manuscripts to peer-reviewed journals, contributing to grant proposals, and mentoring students and visiting fellows. He or she will also gain experience learning about wearable sensor technology.

We seek a motivated and enthusiastic candidate with a keen interest in motor systems neuromodulation and neurophysiology. The candidate must have doctoral experience using noninvasive brain stimulation and/or motor behavioral tasks in humans; the ability to work independently and with a collaborative interdisciplinary team; and be comfortable working with healthy people and people who’ve experienced a stroke. Experience with Python programming language, Igor Pro software, optical motion tracking, movement kinematics, and/or Spanish language proficiency is a plus.

NYU Langone supports the professional development of our postdocs’ academic research career. To apply, submit a CV; a brief cover letter explaining your research experience, interests, goals, and available start date (three pages or less); and the names and contact information of three references who are familiar with your research and academic work to Dr. Heidi Schambra at heidi.schambra@nyumc.org.

Platelets, Inflammation, and Cardiovascular Disease—August 22, 2017

A postdoctoral position is available in the platelet laboratory of Jeffrey S. Berger, MD, MS, at NYU Langone Health’s Leon H. Charney Division of Cardiology. Our laboratory is dedicated to elucidating the mechanism and regulation of platelet- mediated complications in atherogenesis, thrombosis, and inflammatory disease states.

Platelets are major players in the fields of thrombosis and hemostasis and inflammation and immune activation. Increased platelet activity contributes to the pathogenesis of vascular dysfunction, atherosclerosis, thrombosis, and a heightened inflammatory state. Using a combination of human transcriptional profiling studies, mouse models, and cell culture, we aim to identify novel signaling pathways in platelets that contribute to cardiovascular risk.

The postdoc conducts research to investigate novel and targetable signaling pathways in platelets. The successful candidate joins a dedicated and hardworking team determined to achieve results that change the way we treat cardiovascular disease and other inflammatory diseases.

Ideal candidates hold a PhD and/or an MD in biological sciences or biomedical-related fields and must have a solid background in one or more of the following fields: thrombosis and hemostasis, immunology, and/or genetics. We are looking for a creative and driven individual with a strong publication record and advanced expertise in molecular biology (including reverse transcription polymerase chain reaction, or RT-PCR; cloning; immunoprecipitation; and western blotting), flow cytometry, cellular imaging/microscopy, and platelet physiology. Previous experience in high-throughput sequencing, such as RNA sequencing (RNA-seq) and assay for transposase-accessible chromatin (ATAC-seq) techniques, is highly desired.

To apply or to obtain more information about the position, please contact Dr. Berger at jeffrey.berger@nyumc.org. Include a CV, brief statement of research background, and the names of three references.

Checkpoints Signaling and Tumor Immunology—August 11, 2017

A postdoctoral position is available in NYU Langone’s Department of Medicine and Laura and Isaac Perlmutter Cancer Center under the joint mentorship of Adam Mor, MD, PhD, and Mark Philips, MD. The goal of our research is to improve the treatment and outcome of patients with cancers by studying the lymphocyte, the leading cell involved in host response against malignancies. More specifically, we are interested in exploring signaling events related to inhibitory receptors in T cells. The successful candidate will investigate novel and targetable co-receptors signaling pathways in T lymphocytes. The postdoc joins a dedicated and hardworking team determined to reach results that change the way we treat malignancies.

Candidates must have a PhD or MD with a solid background in one or more of the following fields: immunology, cell biology, proteomics (mass spectrometry and data analysis), animal models of tumors, and flow cytometry. Candidates should demonstrate an ability to be creative, be highly motivated, work independently, and have a background in tissue culture, cell biology, and general molecular and biochemical techniques. Experience with confocal imaging is an advantage. Prior postdoctoral experience is acceptable, but not obligatory.

This position is available effective October 1, 2017, and is a one-year appointment renewable for up three years. All applicants must attend an in-person interview in New York City. To apply, send a CV and cover letter describing your scientific experiences to Dr. Mor at adam.mor@nyumc.org.

Wound Repair and Tissue Regeneration—August 3, 2017

A postdoctoral position is available in the laboratory of Daniel J. Ceradini, MD, at NYU Langone for those seeking to conduct independent biomedical research on tissue repair, tissue regeneration, and tissue transplantation/re-engineering.

We investigate novel methods to modulate stem cells and/or their functional environment using several preclinical models in mice and rats. Specifically, we are interested in the impact of oxygen tension on stem/progenitor function and how this can be exploited to restore vascular regeneration in disease states and facilitate the re-engineering of tissue constructs to generate tolerant replacement parts.

Applicants should have a PhD in biomedical sciences with proficiency in molecular biology and immunohistochemical techniques, have experience in tissue regeneration and repair, and be familiar working with animal models and imaging techniques. Additionally, candidates should be able to guide and supervise students and other lab members.

The postdoc will participate in projects dealing with wound repair and tissue regeneration, as well as tissue transplantation/re-engineering, particularly processes involving mesenchymal stem cells in diabetic and other preclinical rodent models. Specifically, he or she will investigate whether modulation of critical molecular regulators of reactive oxygen species-associated pathways during wound healing affects the function of stem/progenitor populations. He or she will also corroborate findings from animal models using human tissues.

This study involves maintaining mouse and rat colonies; performing survival surgery; collecting image data from living animals; harvesting mouse/rat tissue; performing and analyzing Western blots, enzyme-linked immunosorbent assays (ELISAs), and quantitative polymerase chain reaction (PCR); interpreting frozen and paraffin tissue section immunohistochemistry (IHC); and assessing gross phenotypes. The work will entail detailed molecular and phenotypic analyses and preparation of manuscripts for publication.

The specific duties and responsibilities of the postdoc include the following:

  • formulating hypotheses and generating a study design that is appropriate and specific
  • developing and executing experiments and independently analyzing data
  • analyzing and interpreting results in the context of disease pathology
  • applying molecular biology techniques
  • supervising, managing, and maintaining transgenic mouse colonies
  • writing, implementing, and updating mouse and rat protocols in compliance with Institutional Animal Care and Use Committee guidelines
  • maintaining human tissue acquisition protocols in compliance with institutional review board guidelines
  • collaborating with other research staff in lab
  • supervising and training lab members
  • writing and editing manuscripts with relevant literature searches
  • preparing figures and schematic diagrams for publication and presentations
  • writing, editing, and proofreading grant proposals

Please send a cover letter indicating research experience and interests, a CV, and the names and email address of two to three references to Linda Verlin, at linda.verlin@nyumc.org, and Renee McKell, at renee.mckell@nyumc.org.

Transcriptional Networks Regulating Cardiac Rhythm—July 11, 2017

A postdoctoral position is available immediately in the laboratory of David S. Park, MD, PhD, at NYU Langone Health’s Leon H. Charney Division of Cardiology with a focus on studying gene regulatory networks that govern cardiac excitability and repolarization.

Reliable cardiac rhythm is essential for life. Each heartbeat is generated and propagated by the specialized cardiac conduction system, which is composed of pacemaker cells and the rapidly conducting ventricular conduction system.

Using a combination of mouse models, signal transduction screens, and transcriptional profiling libraries, we identify novel gene regulatory networks that govern the electrical properties of cardiac conduction system cells and working myocytes (Park DS, Fishman GI, Cardiovasc Dev Dis. 2017; Shekhar et al., J Clin Invest. 2016; Park et al., Nat Commun. 2016).

We then study the response of these gene regulatory networks to pathological states, such as myocardial infarction and heart failure, with the goal of generating new therapeutic strategies for heart rhythm disorders.

The ideal candidate holds a PhD and/or an MD in biological sciences or biomedical-related fields. Candidates with expertise in molecular and cellular biology, mouse cardiac physiology, mouse surgical techniques (myocardial infarction surgery or transaortic constriction banding), genome editing, and gene network analysis are particularly encouraged to apply.

To apply or to obtain more information about the position, please contact Dr. Park at david.park@nyumc.org. Applicants should include a CV, brief statement of research background, and the names of three references.