Publications

MARTIN BLASER, MD

Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. Anjelique F. Schulfer, Thomas Battaglia, Yelina Alvarez, Luc Bijnens, Victoria E. Ruiz, Melody Ho, Serina Robinson, Tonya Ward, Laura M. Cox, Arlin B. Rogers, Dan Knights, R. Balfour Sartor and Martin J. Blaser. Nature Microbiology. 2017.
 
A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity. Ruiz VE, Battaglia T, Kurtz ZD, Bijnens L, Ou A, Engstrand I, Zheng X, Iizumi T, Mullins BJ, Müller CL, Cadwell K, Bonneau R, Perez GI, Blaser MJ. Nature Communications. 2017; 8, 518 doi:10.1038/s41467-017-00531-6.  

JILL BUYON, MD, AND BORIS REIZIS, PhD

Digestion of chromatin in apoptotic cell microparticles prevents autoimmunity. Sisirak V, Sally B, D’Agati V, Martinez-Ortiz W, Özçakar ZB, David J, Rashidfarrokhi A, Yeste A, Panea C, Bogunovic M, Ivanov II, Quintana FJ, Sanz I, Elkon KB, Tekin M, Yalçınkaya F, Cardozo TJ, Clancy RM, Buyon JP, Reizis B. Cell. 2016 Jun 30;166(1):88–101. PMID: 27293190.   

DNA as a self-antigen: nature and regulation. Soni C, Reizis B. Curr Opin Immunol. 2018 Sep 24;55:31-37.

Plasmacytoid dendritic cells are largely dispensable for the pathogenesis of experimental inflammatory bowel disease. Sawai CM, Serpas L, Neto AG, Jang G, Rashidfarrokhi A, Kolbeck R, Sanjuan MA, Reizis B*, Sisirak V*. Front Immunol. 2018 Oct 25;9:2475.  (*joint corresponding authors).  

Dnase1l3 deletion causes aberrations in length and end motif frequencies in plasma DNA. Serpas L, Chan RWY, Jiang P, Ni M, Sun K, Rashidfarrokhi A, Soni S, Sisirak V, Lee WS, Cheng SH, Peng W, Chan KCA, Chiu RWK, Reizis B*, Lo YMD*. Proc Natl Acad Sci USA. 2019 in press. (*joint corresponding authors).

Plasmacytoid dendritic cells: development, regulation and role in immune responses. Reizis B. Immunity 2019 in press.

KEN CADWELL, PhD

B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains. Wong SY, Coffre M, Ramanan D, Hines MJ, Gomez LE, Peters LA, Schadt EE, Koralov SB, Cadwell K. J Immunol. 2018 Sep 1;201(5):1442-145. PMC6103850

Autophagy proteins suppress protective type I interferon signaling in response to the gut microbiota. Martin PK, Marchiando A, Xu R, Rudensky E, Yeung F, Schuster SL, Kernbauer E, Cadwell K. Nat Microbiol. 2018 Oct;3(10):1131-1141. PMC6179362

Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. Cadwell K, Debnath J. J Cell Biol. 2018 Mar 5;217(3):813-822. PMC5839790

Autophagy and Inflammation. Matsuzawa-Ishimoto Y, Hwang S, Cadwell K. Annu Rev Immunol. 2018 Apr 26;36:73-101. PMC29144836

DAN LITTMAN, MD, PhD

c-Maf-dependent regulatory T cells mediate immunological tolerance to intestinal microbiota.  Xu, M., Pokrovskii, M., Ding, Y., Yi, R., Au, C., Galan, C., Bonneau, R., & Littman, D.R. (2018) Nature, 554, 373-77. PMID: 29414937

Transcriptional regulatory networks that promote and restrict identities and functions of intestinal innate lymphoid cells.  Pokrovskii, M., Hall, J.A., Ochayon, D.E., Yi, R., Chaimowitz, N.S., Seelamneni, H., Carriero, N., Watters, A., Waggoner, S.N., Littman, D.R.*, Bonneau, R.* & Miraldi, E.R. (2018) bioRxiv 292987

Critical role for the microbiota in CX3CR1+ intestinal mononuclear phagocyte regulation of intestinal T cell responses. Kim, M., Galan, C., Hill, A.A., Wu, W-J., Fehlner-Peach, H., Song, H.W., Schady, D., Bettini, M.L., Simpson, K.W., Longman, R.S., Littman, D.R. & Diehl, G.E. (2018).  Immunity 49, 151-63.  PMID:  29980437

TIMOTHY NIEWOLD, MD

Associations Between Type I Interferon and Antiphospholipid Antibody Status Differ Between Ancestral Backgrounds.  Iwamoto T, Dorschner JM, Jolly M, Huang XY, Niewold TB. Lupus Sci Med 2018;5:e000246.

Lupus-associated functional polymorphism in PNP causes cell cycle abnormalities in human immune cells. Ghodke-Puranik Y, Dorschner JM, Vsetecka DM, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Eliopoulos E, Zervou MI, Goulielmos GN, Jensen MA, Niewold TB. Arthritis & Rheumatology. 2017 Dec;69:2328-2337.

A novel ELANE mutation associated with inflammatory arthritis, defective NET-osis, and recurrent parvoviral infection. Thanarajasingam U, Jensen MA, Dorschner JM, Wampler Muskardin T, Ghodke-Puranik Y, Purmalek M, Eliopoulos E, Zervou MI, Goulielmos GN, Howard M, Kaplan MJ, Niewold TB. Arthritis & Rheumatology. 2017 Dec;69:2396-2401.

By Cytof: Heterogeneity of human monocytes. Loke P, Niewold TB. [Editorial] Arteriosclerosis, Thrombosis, and Vascular Biology. 2017 Aug;37:1423–24.
Type I interferon in rheumatic diseases.  Wampler Muskardin TL, Niewold TBNature Reviews Rheumatology. 2018 Mar;14:214-228.  

JOSE SCHER, MD, AND SERGEI KORALOV, PhD

The lung microbiota in early rheumatoid arthritis and autoimmunity. Jose U. Scher, Vijay Joshua, Alejandro Artacho, Shahla Abdollahi-Roodsaz, Johan Öckinger, Susanna Kullberg, Magnus Sköld, Anders Eklund, Johan Grunewald, Jose C. Clemente, Carles Ubeda, Leopoldo N. Segal, and Anca I. Catrina. Microbiome. 2016.11.17.

Short- and long-term effects of oral vancomycin on the human intestinal microbiota. Sandrine Isaac, Jose U. Scher, Ana Djukovic, Nuria Jimenez, Dan R. Littman, Steven B. Abramson, Eric G. Pamer, and Carles Ubeda. Journal of Antimicrobial Chemotherapy. 2016.10.05.

The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventions. Shahla Abdollahi-Roodsaz, Steven B. Abramson, and Jose U. Scher. Nature Reviews Rheumatology. 2016.06.03.

miRNAs in B cell development and Lymphomagenesis. Coffre M and Koralov SB. Trends in Molecular Medicine. 2017 Aug;23(8):721–736.

Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis. Manasson J, Shen N, Garcia Ferrer HR, Ubeda C, Iraheta I, Heguy A, Von Feldt JM, Espinoza LR, Garcia Kutzbach A, Segal LN, Ogdie A, Clemente JC, Scher JU. Arthritis Rheumatol. 2018 Feb;70(2):242-254. doi: 10.1002/art.40359. Epub 2018 Jan 3.

The role of the gut microbiome in systemic inflammatory disease. Clemente JC, Manasson J, Scher JU. BMJ. 2018 Jan 8;360:j5145. doi: 10.1136/bmj.j5145.

Augmented Th17 Differentiation Leads to Cutaneous and Musculoskeletal Inflammation in a Novel Model of Psoriatic Arthritis. Lu Yang, Melania H. Fanok, Aranzazu Mediero-Munoz, Laura K. Fogli, Shahla Abdollahi, Bruce N. Cronstein, Jose U. Scher, Sergei B. Koralov. Arthritis Rheumatol. 2018 Feb 13. doi: 10.1002/art.40447.

Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis. Rebecca Rogier, Heather Evans-Marin, Julia Manasson, Peter van der Kraan, Birgitte Walgreen, Monique Helsen, Liduine van den Bersselaar, Fons van de Loo, Peter van lent, Steven Abramson, Wim van den Berg, Marije Koenders, Jose U. Scher, and Shahla Abdollahi-Roodsaz. Sci Rep. 2017 Nov 15;7(1):15613. doi: 10.1038/s41598-017-15802-x.

GREGG SILVERMAN, MD

Is Gut Microbial LPS a Potential Trigger of Juvenile Idiopathic Arthritis? Doua F. Azzouz and Gregg J. Silverman. The Journal of Rheumatology. 2017;44;1569–1571.

Persistence of Disease-Associated Anti-Citrullinated Protein Antibody-Expressing Memory B Cells in Rheumatoid Arthritis in Clinical Remission. Pelzek AJ, Grönwall C, Rosenthal P, Greenberg JD, McGeachy M, Moreland L, Rigby WF, Silverman GJ. Arthritis & Rheumatology. 2017 Jun;69(6):1176-1186. doi: 10.1002/art.40053. E-pub 2017 May 3.PMID: 28118534.

Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity. Grönwall C, Clancy RM, Getu L, Lloyd KA, Siegel DL, Reed JH, Buyon JP, Silverman GJ. Journal of Autoimmunity. 2016. S0896-8411(16)30075-0. doi: 10.1016/j.jaut.2016.05.14. PMID:27289167.

Unbiased RACE based massive parallel surveys of duplexed human antibody repertoires. Methods in Molecular Biology El. Bannoudi H, Silverman GJ 2017;1643:45-73. doi: 10.1007/978-1-4939-7180-0_5. PMID: 28667529.

Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal. D.F. Azzouz, A. Omarbekova, A.Heguy, D. Schwudke, N. Gisch, B. H. Rovin, R. Caricchio5, J. P. Buyon, A. V. Alekseyenko and G. J. Silverman. Annals Rheumatic Diseases, in press

The microbiome in SLE pathogenesis. Silverman GJ. Nat Rev Rheumatol. 2019 Jan 3. doi: 10.1038/s41584-018-0152-z. [Epub ahead of print]

Essential Domain-Dependent Roles Within Soluble IgG for in vivo Superantigen Properties of Staphylococcal Protein A: Resolving the B-Cell Superantigen Paradox. Ulloa-Morales AJ, Goodyear CS, Silverman GJ. Front Immunol. 2018 Sep 19;9:2011. doi: 10.3389/fimmu.2018.02011. eCollection 2018.