Judith & Stewart Colton Center for Autoimmunity Publications
Researchers at NYU Langone’s Judith and Stewart Colton Center for Autoimmunity regularly publish their work on the immunological basis of autoimmune diseases in prominent peer-reviewed journals.
Below are highlights from our faculty’s recent publications.
Martin J. Blaser, MD
Schulfer AF . . . Blaser MJ. Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. Nat Microbiol. 2017. DOI.
Ruiz VE . . . Blaser MJ. A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity. Nat Commun. 2017. DOI.
Steven Burden, PhD, and Damian Ekiert, PhD
Fichtner ML … O’Connor KC. Self-Antigen Driven Affinity Maturation is Required for Pathogenic Monovalent IgG4 Autoantibody Development. J Exp Med. 2020. DOI.
Jill P. Buyon, MD, and Boris Reizis, PhD
Soni C and Reizis B. Self-DNA at the epicenter of SLE: Immunogenic forms, regulation, and effects. Front Immunol. 2019. DOI.
Reizis B. Plasmacytoid dendritic cells: Development, regulation, and function. Immunity. 2019. DOI.
Serpas L . . . Lo YMD. Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA. Proc Natl Acad Sci USA. 2019. DOI.
Sawai CM . . . Sisirak V. Plasmacytoid dendritic cells are largely dispensable for the pathogenesis of experimental inflammatory bowel disease. Front Immunol. 2018. DOI.
Soni C and Reizis B. DNA as a self-antigen: Nature and regulation. Curr Opin Immunol. 2018. DOI.
Sisirak V . . . Reizis B. Digestion of chromatin in apoptotic cell microparticles prevents autoimmunity. Cell. 2016. DOI.
Ken H. Cadwell, PhD, and P’ng Loke, PhD
Neil JA . . . Cadwell K. IFN-I and IL-22 mediate protective effects of intestinal viral infection. Nat Microbiol. 2019. DOI.
Martin PK . . . Cadwell K. Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota. Nat Microbiol. 2018. DOI.
Wong SY . . . Cadwell K. B cell defects observed in Nod2 knockout mice are a consequence of a Dock2 mutation frequently found in inbred strains. J Immunol. 2018. DOI.
Matsuzawa-Ishimoto Y, Hwang S, and Cadwell K. Autophagy and inflammation. Annu Rev Immunol. 2018. DOI.
Cadwell K and Debnath J. Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. J Cell Biol. 2018. DOI.
Stefan Feske, MD, and Rodrigo S. Lacruz, MSc, PhD
Vaeth M . . . Feske S. Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels. Nat Commun. 2019. DOI.
Dan R. Littman, MD, PhD
Chen H … Alt FW. BCR Selection and Affinity Maturation in Peyer's Patch Germinal Centres. Nature. 2020. DOI.
Lee JL ... Littman DR. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. Cell. 2020. DOI.
Teruyuki S … Littman DR. Redundant Cytokine Requirement for Intestinal Microbiota-Induced Th17 Cell Differentiation in Draining Lymph Nodes. bioRxiv. 2020. DOI.
Fehlner-Peach H . . . Littman DR. Distinct polysaccharide utilization profiles of human intestinal Prevotella copri isolates. 2019. Cell Host Microbe. DOI.
Pokrovskii M . . . Miraldi ER. Characterization of transcriptional regulatory networks that promote and restrict identities and functions of intestinal innate lymphoid cells. Immunity. 2019. DOI.
Xu M . . . Littman DR. c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature. 2018. DOI.
Kim M . . . Diehl GE. Critical role for the microbiota in CX3CR1+ intestinal mononuclear phagocyte regulation of intestinal T cell responses. Immunity. 2018. DOI.
Timothy Niewold, MD
Salmon JE, Niewold TB. A Successful Trial for Lupus – How Good Is Good Enough? N Engl J Med. 2020. DOI.
Thanarajasingam U . . . Niewold TB. Type I interferon predicts an alternate immune system phenotype in systemic lupus erythematosus. ACR Open Rheumatol. 2019. DOI.
Sinicato NA . . . Appenzeller S. Familial aggregation in childhood and adulthood-onset systemic lupus erythematosus. Arthritis Care Res. 2019. DOI.
Ghodke-Puranik Y . . . Niewold TB. Novel genetic associations with interferon in systemic lupus erythematosus identified by replication and fine-mapping of trait-stratified genome-wide screen. Cytokine. 2019. DOI.
Iwamoto T . . . Niewold TB. Associations between type I interferon and antiphospholipid antibody status differ between ancestral backgrounds. Lupus Sci Med. 2018. DOI.
Muskardin TLW and Niewold TB. Type 1 interferon in rheumatic diseases. Nat Rev Rheumatol. 2018. DOI.
Ghodke-Puranik Y . . . Niewold TB. Lupus-associated functional polymorphism in PNP causes cell cycle abnormalities and interferon pathway activation in human immune cells. Arthritis Rheumatol. 2017. DOI.
Thanarajasingam U . . . Niewold TB. Brief report: A novel ELANE mutation associated with inflammatory arthritis, defective NETosis, and recurrent parvovirus infection. Arthritis Rheumatol. 2017. DOI.
Jose U. Scher, MD, and Sergei B. Koralov, PhD
Scher JU … Abramson SB. Pharmacomicrobiomics in Inflammatory Arthritis: Gut Microbiome as Modulator of Therapeutic Response. Nat Rev Rheumatol. 2020. DOI.
Herrera A . . . Koralov SB. Low SATB1 expression promotes IL-5 and IL-9 expression in Sézary Syndrome. J Invest Dermatol. 2019. DOI.
Mimitou E … Smibert P. Expanding the CITE-seq Tool-Kit: Detection of Proteins, Transcriptomes, Clonotypes and CRISPR Perturbations in Single Cells. Nature Methods. 2019. DOI.
Evans-Martin H … Abdollahi-Roodsaz S. Microbiota‐Dependent Involvement of Th17 Cells in Murine Models of Inflammatory Arthritis. Arthritis and Rheum. 2018. DOI.
Wong SY … Cadwell K. B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains. J Immunol. 2018. DOI.
Yang L . . . Koralov SB. Augmented Th17 differentiation leads to cutaneous and synovio-entheseal inflammation in a novel model of psoriatic arthritis. Arthritis Rheumatol. 2018. DOI.
Clemente JC, Manasson J, and Scher, JU. The role of the gut microbiome in systemic inflammatory disease. BMJ. 2018. DOI.
Manasson J . . . Scher JU. Gut microbiota perturbations in reactive arthritis and postinfectious spondyloarthritis. Arthritis Rheumatol. 2018. DOI.
Cao W… Sundrud MS. The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids. Immunity. 2017. DOI.
Rogier R . . . Abdollahi-Roodsaz S. Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis. Sci Rep. 2017. DOI.
Isaac S . . . Ubeda C. Short- and long-term effects of oral vancomycin on the human intestinal microbiota. J Antimicrob Chemother. 2017. DOI.
Scher JU . . . Catrina AI. The lung microbiota in early rheumatoid arthritis and autoimmunity. Microbiome. 2016. DOI.
Gregg Silverman, MD
Silverman GJ, Azzouz DF. Response to: 'The Level of Peripheral Regulatory T Cells is Linked to Changes in Gut Commensal Microflora in Patients with Systemic Lupus Erythematosus' by Zhang et al and the Phylogeny of a Candidate Pathobiont in Lupus Nephritis. Ann Rheum Dis. 2019. DOI.
Silverman GJ, Azzouz DF, and Alekseyenko AV. Systemic lupus erythematosus and dysbiosis in the microbiome: Cause or effect or both? Curr Opin Immunol. 2019. DOI.
Silverman GJ. The microbiome in SLE pathogenesis. Nat Rev Rheumatol. 2019. DOI.
Azzouz D . . . Silverman GJ. Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal. Ann Rheum Dis. 2019. DOI.
El Bannoudi H . . . Silverman GJ. Unbiased RACE-based massive parallel surveys of human IgA antibody repertories. Methods in Mol Biol. 2017. DOI.
Azzouz DF and Silverman GJ. Is gut microbial LPS a potential trigger of juvenile idiopathic arthritis? J Rheumatol. 2017. DOI.
Pelzek AJ . . . Silverman GJ. Persistence of disease-associated anti-citrullinated protein antibody-expressing memory B cells in rheumatoid arthritis in clinical remission. Arthritis Rheumatol. 2017. DOI.
Grönwall C . . . Silverman GJ. Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity. J Autoimmun. 2016. DOI.