Judith & Stewart Colton Center for Autoimmunity Publications
Researchers at NYU Langone’s Judith and Stewart Colton Center for Autoimmunity regularly publish their work on the immunological basis of autoimmune diseases in prominent peer-reviewed journals.
Below are highlights from our faculty’s recent publications.
Jill P. Buyon, MD, and Boris Reizis, PhD
Sisirak V … Reizis B. Digestion of chromatin in apoptotic cell microparticles prevents autoimmunity. Cell. 2016. DOI.
Ken H. Cadwell, PhD
Wong SY … Cadwell K. Intramicrobiome interactions mediated pathological TLR4 signaling during Nod2 deficiency. (In preparation)
Lea Ann Chen, MD
Tang MS … Loke P. Integrated analysis of biopsies from inflammatory bowel disease patients identifies SAA1 as a link between mucosal microbes with TH17 and TH22 cells. Inflamm Bowel Dis. 2017. DOI.
Bowcutt R … Loke P. Isolation and cytokine analysis of lamina propria lymphocytes from mucosal biopsies of the human colon. J Immunol Methods. 2015. DOI.
Hourigan SK … Oliva-Hemker M. Microbiome changes associated with sustained eradication of Clostridium difficile after single faecal microbiota transplantation in children with and without inflammatory bowel disease. Aliment Pharmacol Ther. 2015. DOI.
Chen LA … Sears CL. Decreased fecal bacterial diversity and altered microbiome composition in children colonized with Clostridium difficile. J Pediatr Gastroenterol Nutr. 2019; 68(4):502–508.
Dan R. Littman, MD, PhD
Xu M … Littman DR. c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature. 2018. DOI.
Kim S … Huh JR. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature. 2017. DOI.
Yim YS … Choi GB. Reversing behavioural abnormalities in mice exposed to maternal inflammation. Nature. 2017. DOI.
Galan C … Diehl GE. The microbiota conditions CX CR1+ intestinal mononuclear phagocytes to regulate pro- and anti-inflammatory intestinal T cell responses. (Submitted)
Timothy Niewold, MD
Jenks SA … Sanz I. Distinct effector B cells induced by unregulated Toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus. Immunity. 2018. DOI.
Juge PA … Dieudé P. MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease. N Engl J Med. 2018. DOI.
Ghodke-Puranik Y … Niewold TB. Lupus-associated functional polymorphism in PNP causes cell cycle abnormalities and interferon pathway activation in human immune cells. Arthritis Rheumatol. 2017. DOI.
Loke P and Niewold TB. By CyTOF: Heterogeneity of human monocytes. Arterioscler Thromb Vasc Biol. 2017. DOI.
Thanarajasingam U … Niewold TB. Brief report: A novel ELANE mutation associated with inflammatory arthritis, defective NETosis, and recurrent parvovirus infection. Arthritis Rheumatol. 2017. DOI.
Johannes Nowatzky, MD
Nowatzky J … Bhardwaj N. CD11b/CD18 ligation of monocyte-derived dendritic cells dampens human Th17 cell responses (52.6). J Immunol. 2012;188(1 Suppl):52.6.
Jose U. Scher, MD, and Sergei B. Koralov, PhD
Manasson J … Scher JU. Gut microbiota perturbations in reactive arthritis and postinfectious spondyloarthritis. Arthritis Rheumatol. 2018. DOI.
Yang L … Koralov SB. Augmented Th17 differentiation leads to cutaneous and synovio-entheseal inflammation in a novel model of psoriatic arthritis. Arthritis Rheumatol. 2018. DOI.
Coffre M and Koralov SB. miRNAs in B cell development and lymphomagenesis. Trends Mol Med. 2017. DOI.
Isaac S … Ubeda C. Short- and long-term effects of oral vancomycin on the human intestinal microbiota. J Antimicrob Chemother. 2017. DOI.
Rogier R … Abdollahi-Roodsaz S. Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis. Sci Rep. 2017. DOI.
Abdollahi-Roodsaz S, Abramson SB, and Scher JU. The metabolic role of the gut microbiota in health and rheumatic disease: Mechanisms and interventions. Nat Rev Rheumatol. 2016. DOI.
Scher JU … Catrina AI. The lung microbiota in early rheumatoid arthritis and autoimmunity. Microbiome. 2016. DOI.
Gregg Silverman, MD
Azzouz DF and Silverman GJ. Is gut microbial LPS a potential trigger of juvenile idiopathic arthritis? J Rheumatol. 2017. DOI.
Bannoudi H and Silverman GJ. Unbiased RACE-based massive parallel surveys of human IgA antibody repertoires. Methods in Mol Biol. 2017. DOI.
Pelzek AJ … Silverman GJ. Persistence of disease-associated anti–citrullinated protein antibody–expressing memory B cells in rheumatoid arthritis in clinical remission. Arthritis Rheumatol. 2017. DOI.
Grönwall C … Silverman GJ. Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity. J Autoimmun. 2016. DOI.
Anquetil C … Silverman GJ. Predominance of IgA autoantibodies in SLE. (In preparation)
Azzouz D … Silverman GJ. Strains of an aerobic gut commensal are linked to lupus nephritis. (In preparation)