Emotion & Brain Injury Rehabilitation Research
At NYU Langone’s Rusk Rehabilitation, Prin X Amorapanth, MD, PhD, a physician–scientist, examines how neuroplasticity may alleviate functional impairments in people with acquired brain injuries and translates findings into novel neurorehabilitation treatments.
Dr. Amorapanth’s research seeks to identify markers of visuospatial impairment after acquired brain injury as well as noninvasive brain stimulation as both a therapeutic and investigative tool for improving rehabilitation and better understanding the mechanisms of recovery after brain injury.
Early in his career, Dr. Amorapanth helped identify distinct neural circuits in a fear pathway mediating different types of conditioned fear responses. This finding shifted away from the belief that conditioned fear was tied to a single circuit and showed that different areas within the brain, including the amygdala, are involved in fear response. This finding led to further studies that allowed Dr. Amorapanth to develop novel targeted diagnostic and treatment tools for emotional disorders in people with traumatic brain injury.
Dr. Amorapanth is currently investigating transcranial electrical stimulation as an adjunctive therapy for the rehabilitation of cognitive and emotional impairments in people with chronic traumatic brain injuries. His team of researchers assessed subjects with chronic traumatic brain injuries using a number of cognitive, emotional, and physiologic measures before and after transcranial stimulation. Subjects then watched film clips meant to elicit specific emotions and recorded their autonomic nervous system activity, which provided the team with an additional objective measure for assessing emotional responses. The team found that the subjects displayed different patterns of autonomic activity in response to emotional stimuli despite showing no changes in their subjective perceptions of these stimuli.
These changes in autonomic activity correlated with impaired attention as well. Data from this study also suggest a trend toward improved performance on measures of facial affect recognition and orienting attention in chronic traumatic brain injury subjects who received stimulation, as well as very few adverse side effects of stimulation and no adverse medical events.
Challenges and Lessons Learned for Acute Inpatient Rehabilitation of Persons With COVID-19: Clinical Presentation, Assessment, Needs, and Services Utilization
American journal of physical medicine & rehabilitation. 2021 12 01; 100:1115-1123
Altered Relationship between Working Memory and Brain Microstructure after Mild Traumatic Brain Injury
AJNR. American journal of neuroradiology. 2019 Sep ; 40:1438-1444
MULES on the sidelines: A vision-based assessment tool for sports-related concussion
Journal of the neurological sciences. 2019 Apr 28; 402:52-56
Mobile Universal Lexicon Evaluation System (MULES) in MS: Evaluation of a new visual test of rapid picture naming
Journal of the neurological sciences. 2018 Nov 15; 394:1-5
White Matter Tract Integrity: An Indicator Of Axonal Pathology After Mild Traumatic Brain Injury
Journal of neurotrauma. 2018 Apr 15; 35:1015-1020
The new Mobile Universal Lexicon Evaluation System (MULES): A test of rapid picture naming for concussion sized for the sidelines
Journal of the neurological sciences. 2018 Apr 15; 387:199-204
Traumatic brain injury results in altered physiologic, but not subjective responses to emotional stimuli
Brain injury. 2018 Jan ; 32:1712-1719
The effect of linguistic background on rapid number naming: implications for native versus non-native English speakers on sideline-focused concussion assessments
Brain injury. 2018 Mar ; 32:1690-1699