As leaders in the discovery and translation of new knowledge into policy and practice, the Department of Population Health has a large and growing portfolio of extramural funding aligned with our goal of advancing the health of populations. Core areas of research span the basic, clinical, and applied sciences and include behavior change, comparative effectiveness, epidemiology, biostatistics, decision science, cost effectiveness, behavioral economics, and medical ethics. Woven through these core areas are common themes and disease-specific foci. Themes include a commitment to research that addresses local and global communities; vulnerable populations; health disparities; health care delivery and system design; and social, genetic, and environmental determinants of health. Disease-specific foci include obesity, cardiovascular disease, cancer, tobacco and drug use, and preventable infections. Our research bridges disciplines and embraces partnerships with clinicians, communities, and policymakers.