Department of Medicine Research Areas
Researchers within the subspecialty divisions of the Department of Medicine at NYU Langone are advancing the frontiers of biomedical investigation.
Investigators in the Leon H. Charney Division of Cardiology are leaders in basic, translational, clinical, and population-based cardiovascular investigation. Major areas of interest include vascular biology and disease, lipid biology and atherosclerosis, ion channel biology and arrhythmogenic heart disease, immunometabolism, cardiovascular genetics and inherited heart disease, cardiovascular prevention, and women’s heart disease.
The Division of Cardiology is home to several specialized research and clinical centers that comprise numerous faculty and trainees, including NYU Langone’s Center for the Prevention of Cardiovascular Disease, Cardiovascular Clinical Research Center, Heart Rhythm Center, and Heart Valve Center.
Each center is supported by extensive National Institutes of Health, foundation, and philanthropic support, and all are dedicated to improving cardiovascular health. Learn more about our cardiovascular research.
Endocrinology, Diabetes, and Metabolism Research
Investigators in the Division of Endocrinology, Diabetes, and Metabolism are researching new methods of diagnosing and treating thyroid cancer, better management therapies for diabetes and obesity, and strategies for minimizing cardiovascular disease risk in patients with diabetes.
Translational researchers in the Diabetes Research Program are examining the molecular underpinnings of diabetes and obesity, including the receptor for advanced glycation end products (RAGE) pathways, to pave the way for more effective treatments in the future. Others are developing new algorithms to determine the best medications to minimize atherosclerosis risk in patients with diabetes and devising best practices for incorporating mobile health technology into diabetes self-management. Learn more about our endocrinology, diabetes, and metabolism research.
Gastroenterology and Hepatology Research
Investigators in the Division of Gastroenterology and Hepatology are expanding our understanding of pancreatic cancer’s ability to evade the immune system, the risks and benefits of particular bariatric surgical techniques in specific patient populations, pouch surgery for ulcerative colitis and Crohn’s disease, the importance of collaborative disease management for patients with inflammatory bowel disease, and antiviral therapies for hepatitis C. Learn more about our gastroenterology and hepatology research.
General Internal Medicine and Clinical Innovation Research
Investigators in the Division of General Internal Medicine and Clinical Innovation conduct basic and translational research and clinical trials on topics such as patient safety, shared decision-making, practice management, medical education, hospital medicine, obesity, and clinical innovation.
Our faculty also collaborate with other departments to conduct research related to comparative effectiveness, cost-effectiveness, postoperative care, behavioral economics, medical informatics and e-technology, chronic disease and substance abuse prevention and treatment, and immigrant health. Learn more about our general internal medicine and clinical innovation research.
Geriatric Medicine and Palliative Care Research
Investigators in the Division of Geriatric Medicine and Palliative Care collaborate with the Department of Neuroscience and Physiology and the Department of Population Health on basic science, translational research, and clinical trials to advance care for patients with Alzheimer’s disease and other dementias, bone and joint conditions, diabetes, hypertension, incontinence, memory loss, and urinary tract infections.
Hematology and Medical Oncology Research
Investigators in the Division of Hematology and Medical Oncology are developing new cytotoxic agents, multimodality treatments, and cancer prevention strategies and are studying biomarkers in early cancer development as diagnostic and prognostic tools.
Members of the hematology research team at Perlmutter Cancer Center are investigating high-dose vitamin C, which boosts production of an enzyme that encourages bone marrow stem cells to mature and die, as a treatment option for patients with certain types of leukemia and preleukemia. In the Clinical Leukemia Program, researchers are testing a combination of a first-in-kind B-cell lymphoma 2 (Bcl-2) protein/gene with current standard of care as a possible new treatment for acute myeloid leukemia.
Medical oncologists in our High-Risk Cancer Genetics Program are examining hereditary syndromes that increase cancer risk and methods for improving outcomes in underserved populations, such as increasing access to risk reduction programs and genetic counseling. Learn more about our hematology and medical oncology research.
Infectious Diseases and Immunology Research
Investigators in the Division of Infectious Diseases and Immunology conduct basic science investigations, translational research, clinical trials, and epidemiological studies on topics such as HIV pathogenesis, tuberculosis, malaria, staphylococcal infections, the human microbiome, and healthcare-associated infections. Learn more about our infectious diseases and immunology research.
Investigators in the Division of Nephrology perform basic science research on the impact of kidney disease on the gut microbiome, physiological research on the cardiovascular complications of dialysis, and translational and genetics research on the causes of rare kidney stones.
Clinical trials on topics such as nephrolithiasis and hemodialysis are ongoing. Learn more about our nephrology research.
Precision Medicine Research
Investigators in the Division of Precision Medicine are conducting research in several areas, including inflammation and anti-inflammatory drugs, wound healing, hepatic cirrhosis, angiogenesis and atherosclerosis, new cancer therapies, and pathways linking perceived stress and altered immunity. Learn more about our precision medicine research.
Pulmonary, Critical Care, and Sleep Medicine Research
Investigators in the Division of Pulmonary, Critical Care, and Sleep Medicine conduct laboratory-based investigations, translational research, clinical trials, and epidemiological studies focused on conditions ranging from cancer and inflammatory diseases such as chronic obstructive pulmonary disease (COPD) and asthma, to infectious respiratory disorders and environmental lung disease.
Researchers in our federally funded World Trade Center Health Program are exploring the mechanisms of lung injuries, developing biomarkers to identify patients at risk for adverse pulmonary outcomes, and providing ongoing care for medically affected rescue and responder populations.
Other researchers are developing immunotherapy trials for patients with lung cancer and mesothelioma who aren’t candidates for surgery, studying the role of immunoglobulin E antibodies in allergic disease, and investigating airway microbe–host interaction and the microbiome in the development of lung diseases such as COPD and lung cancer. Learn more about our pulmonary, critical care, and sleep medicine research.
Investigators in the Division of Rheumatology focus on three main research areas: diseases of systemic autoimmunity, inflammatory and autoimmune arthritis, and degenerative and metabolic joint and bone disease. Research is facilitated at two comprehensive bench-to-bedside centers—NYU Langone’s Lupus Center and Psoriatic Arthritis Center—which are supported by grants from the National Institutes of Health, foundations, and philanthropy. Our division is highly integrated with the Judith and Stewart Colton Center for Autoimmunity and is home to the largest registry of people with neonatal lupus.
Ongoing lupus research initiatives involve investigating disease mechanisms to determine why some at-risk women develop lupus and others do not, sequencing the gut microbiome to better understand the root causes of disease flares and kidney injury progression, understanding the role of DNase1L3 and advanced molecular sequencing of autoantibodies, identifying pregnancy risk factors, and leveraging transcriptomic analysis of kidney and skin biopsies to identify novel targets for therapy. We also study lupus in older patients and the need to adjust medication after many years of exposure. Learn more about our rheumatology research.