Program Objectives

Specific objectives for the Pediatric Hematology/Oncology rotation are outlined below and are based on recommendations published previously (A.D. Lascari et al Am J Ped Hem Onc. 8: 245-47,1986)

To develop a differential diagnosis and work up for *:

  • Anemia
  • Neutropenia
  • Thrombocytopenia
  • Thrombocytosis
  • Pancytopenia
  • Adenopathy
  • Splenomegaly
  • Abdominal mass
  • Mediastanal mass
  • Thrombosis
  • Bruising and bleeding

To understand the diagnosis, pathophysiology and management of the following hematological conditions:

  • Hemophilia, Von Willebrand disease *
  • Vitamin K deficiency *
  • Congenital thrombocytopenia
  • Platelet function disorders
  • Disseminated intravascular coagulation *
  • Hemolytic uremic syndrome
  • Immune thrombocytopenia, anemia, neutropenia
  • Red blood cell membrane defects *
  • Hemoglobinopathies *
  • Red blood cell enzymes defects
  • Transient erytroblastopenia
  • Aplastic anemia

To be familiar with the diagnosis, molecular basis and management of the following oncological conditions:

  • Pathogenesis of Childhood cancer *
  • Acute lymphoblastic leukemia *
  • Acute myelogenous leukemia
  • Histiocytosis
  • Hodgkin's disease
  • Non-Hodgkin's lymphoma
  • Brain tumors *
  • Neuroblastoma
  • Renal tumors
  • Bone and soft tissue sarcomas
  • Retinoblastoma
  • Hepatic tumors

To understand the principles of therapy of commonly encountered hematological and oncological conditions*:

  • Chemotherapy
  • Transfusion therapy, pheresis therapy
  • Management of coagulopathy
  • Management of sickle cell disease/thalassemia and transfusional hemochromatosis
  • Tumor lysis syndrome and other oncological emergencies
  • Deep venous thrombosis and pulmonary embolism
  • Management of fever and neutropenia

* Special emphasis