Research Areas

Bench in Ernst Lab

Divisions of the Department of Medicine

Vascular Biology and Disease, Myocardial Biology and Heart Failure, Cardiac Excitability and Arrhythmias, Cardiovascular Development and Genetics.

Endocrinology, Diabetes, and Metabolism
Lipodystrophy and hyperlipidemia, control of mammary gland development, cellular response to proteotoxic stress, hypertriglyceridemia, HIV-associated metabolic dysfunction, acromegaly, adult GH deficiency, therapies for Type-2 diabetes and macrovascular disease.

Liver diseases (especially hepatitis C), Endoscopy, Colon cancer screening, Acute and chronic GI bleeding, Helicobacter pylori; outcomes research in gastroenterology and hepatology.

General Internal Medicine and Clinical Innovation
Medical education, doctor-patient communication, health disparities, immigrant health, torture and its impact, research methodology, cardiovascular prevention and testing, geriatrics, medical informatics, and medical genetics.

Hematology and Medical Oncology
Development and testing of new biologic and synthetic cytotoxic agents; multimodality treatment; platelet physiology, oncogenes and molecular oncology, molecular biology of polycythemia vera, amyloidosis, HTLV-associated disorders, tyrosine kinases, bone marrow transplantation, angiogenesis, drug resistance in acute leukemia, lymphoma pathogenesis and lymphoma vaccines, HIV-associated malignancies, mechanisms of tumor metastasis.

Infectious Diseases and Immunology
AIDS research, Microbiology and Microbial Pathogenesis, Microbial Immunity and Immunology, Parasitology, Population Biology of Infectious Diseases.

Immune mechanisms of glomerular disease, signal transduction mechanisms, role of cyclin-dependent kinases (CDKs) as therapeutic targets in kidney disease, electrolyte transport across intestinal epithelia.

Pulmonary, Sleep, and Critical Care Medicine
Respiratory physiology and sleep disorders, tuberculosis, lung cancer, asthma, occupational and environmental lung disease, critical care.

Biology of inflammation and autoimmunity, including the role of leukocytes, endothelium, complement, cytokines, and eicosanoids, as well as the role of intracellular signaling cascades in inflammation.

Translational Medicine
Inflammation and anti-inflammatory drugs, wound healing and agents designed to enhance wound healing, hepatic cirrhosis and its therapy, angiogenesis and atherosclerosis, new therapies for the treatment of cancer.