Research Focus

Thoracic cancer investigators at the Perlmutter Cancer Center are focusing on the following broad areas study:

  • Screening and Early Detection
  • The biology of thoracic malignancies
  • National multi-institutional trials in thoracic malignancies

Screening and Early Detection

Current research includes such topics as:

  • Development of novel blood based biomarkers for the detection of lung cancer and malignant mesothelioma and, as well as biomarkers to guide the management of patients
  • Radiology studies which help to define nodule characteristics on CT and MRI in order to improve the accuracy of diagnosis

The Biology of Thoracic Cancers

Current research includes such topics as:

  • MicroRNAs in lung cancer and mesothelioma
  • Mutational analysis of lung cancer and mesothelioma
  • Stem cell like populations in lung cancer and mesothelioma
  • Resistance to therapy for lung cancer and mesothelioma
  • The role of mTOR inhibition in advanced non-small cell lung cancer
  • Immune system activation in non-small cell lung cancer through combination radiation therapy and treatment with monoclonal antibodies targeting CTLA-4
  • Anti-Glycan Antibody profiles as a predictor of response to therapy