Pediatric Nephrology Research | NYU Langone Health

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Division of Pediatric Nephrology Pediatric Nephrology Research

Pediatric Nephrology Research

Researchers in NYU Langone’s Division of Pediatric Nephrology work to improve treatments for kidney disease and hypertension and to develop precision medicine treatments for glomerular disease and kidney injury in children and adolescents.

Investigators in the division are conducting observational cohort studies of children with glomerular disease and studying the impact of environmental chemicals on the progression of kidney disease.

The division’s research activities include studies of the effect of a gluten-free diet on difficult-to-manage nephrotic syndrome. Researchers are also developing a platform clinical trial of precision medicine–based treatments for children and adolescents with glomerular disease. Additionally, they are researching biomarkers to assess the onset and severity of acute kidney injury.

Researchers in the division serve as principal investigators for the Nephrotic Syndrome Study Network for Children (cNEPTUNE) precision medicine clinical trials for baseline immunosuppression exposure, as well as the Cure Glomerulonephropathy (CureGN) prospective observational cohort study. The division maintains industry partnerships with pharmaceutical companies to develop precision medications for glomerular disease.

The pediatric nephrology team is building a clinical program for pediatric kidney transplant in patients who weigh more than 25 kg, or 55 lb. They are working to improve environmental health literacy as a prelude to a clinical trial focusing on reducing chemical exposure and improving outcomes.

The division collaborates with other departments and divisions at NYU Langone to improve the health of children with glomerular disease. Division experts are partnering with the Division of General Pediatrics and the Department of Population Health on a survey study that examines the effects of engaging families and patients in research. The division is also working with the Sala Institute for Child and Family Centered Care and the Clinical and Translational Science Institute to engage families in clinical research at Hassenfeld Children’s Hospital—34th Street.

Together with pediatric endocrinologists and child and adolescent psychologists, division researchers study the impact of kidney disease on families to provide better treatments and an improved quality of life.

Featured Publications

Elevated Levels of Urinary Biomarkers TIMP-2 and IGFBP-7 Predict Acute Kidney Injury in Neonates after Congenital Heart Surgery

Ramírez, Michelle; Chakravarti, Sujata; Busovsky-McNeal, Melissa; McKinstry, Jaclyn; Al-Qaqaa, Yasir; Sahulee, Raj; Kumar, T K Susheel; Li, Xiaochun; Goldberg, Judith D; Gefen, Ashley M; Malaga-Dieguez, Laura

Journal of pediatric intensive care. 2022 Jun ; 11:153-158

Catheter-Directed Thrombolysis for Neonatal IVC and Bilateral Renal Vein Thrombosis: A Case Report

Guichet, Phillip L; Jasinski, Sylwia; Malaga-Dieguez, Laura; De Los Reyes, Francis A; Ahuja, Tania; Bride, Karen L; Patel, Amish

Journal of pediatric hematology/oncology. 2021 May 01; 43:e554-e557

Pulmonary Manifestations of Renal Disorders in Children

Malaga-Dieguez, Laura; Trachtman, Howard; Giusti, Robert

Pediatric clinics of North America. 2021 Feb ; 68:209-222

Center Volume and Kidney Transplant Outcomes in Pediatric Patients

Contento, Marissa N; Vercillo, Rachel N; Malaga-Dieguez, Laura; Pehrson, Laura Jane; Wang, Yuyan; Liu, Mengling; Stewart, Zoe; Montgomery, Robert; Trachtman, Howard

Kidney medicine. 2020 May-Jun; 2:297-306

The Psychosocial Impact of a Diagnosis of Hypertension in Pediatric Patients

Bieber, Amy Kalowitz; Pehrson, Laura Jane; Vento, Suzanne; Malaga-Dieguez, Laura; Spruill, Tanya M; Trachtman, Howard

Kidney international reports. 2020 Feb ; 5:228-230

Hypokalemia Associated With a Claudin 10 Mutation: A Case Report

Meyers, Nicole; Nelson-Williams, Carol; Malaga-Dieguez, Laura; Kaufmann, Horacio; Loring, Erin; Knight, James; Lifton, Richard P; Trachtman, Howard

American journal of kidney diseases. 2019 Mar ; 73:425-428

Infection-associated glomerulonephritis

Malaga-Dieguez, Laura

[S.l. : s.n.], 2019. p.437-450. (3857182)

Interstitial nephritis: Two pediatric cases with atypical radiological features

Connors, Joseph; Aronov, Rachel; Malaga-Dieguez, Laura; Vento, Suzanne; Pehrson, Laura Jane; Wu, Ming; Lala, Shailee; Trachtman, Howard

Radiology case reports. 2018 Oct ; 13:1003-1006