Cancer Cell Biology High-Impact Publications
Research by faculty at Perlmutter Cancer Center’s Cancer Cell Biology Program is published in leading scientific journals.
Biancur DE … Kimmelman AC. Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism. Nat Commun. 2017. DOI.
Chen H … Mohammadi M. Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. eLife. 2017. DOI.
Chung SS … Park CY. CD99 is a therapeutic target on disease stem cells in myeloid malignancies. Sci Transl Med. 2017. DOI.
Cimmino L … Aifantis I. Restoration of TET2 function blocks aberrant self-renewal and leukemia progression. Cell. 2017. DOI.
Court H … Philips MR. Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT. J Cell Biol. 2017. DOI.
Fehrenbacher N … Philips MR. The G protein-coupled receptor GPR31 promotes membrane association of KRAS. J Cell Biol. 2017. DOI.
Goldman KN … Schneider RJ. mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy. Proc Natl Acad Sci USA. 2017. DOI.
Kuchay S … Pagano M. PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017. DOI.
Modrek AS … Placantonakis DG. Low-grade astrocytoma mutations in IDH1, P53, and ATRX cooperate to block differentiation of human neural stem cells via repression of SOX2. Cell Rep. 2017. DOI.
Pae J … Lehmann R. GCL and CUL3 control the switch between cell lineages by mediating localized degradation of an RTK. Dev Cell. 2017. DOI.
Pekar O … Hubbard EJA. Linking the environment, DAF-7/TGFbeta signaling and LAG-2/DSL ligand expression in the germline stem cell niche. Developement. 2017. DOI.
Romero R … Papagiannakopoulos T. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. Nat Med. 2017. DOI.
Sayin VI … Papagiannakopoulos T. Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. eLife. 2017. DOI.
Wang X … Wu X-R. Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin. Sci Rep. 2017. DOI.
Yin JC … Neel BG. Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome. Nat Commun. 2017. DOI.