Facilities and Research Cores

 

Protein Mass Spectrometry Core Facility for Neuroscience

Since its establishment in 2005, the New York University Protein Mass Spectrometry Core Facility for neuroscience has provided cutting edge mass spectrometry-based protein analysis to molecular neuroscientists at the New York University School of Medicine. Funding from NIH-NINDS has enabled neuroscientists at NYU to take advantage of sophisticated and involved protein mass spectrometry and proteomics that would otherwise not be available to them, and guarantee them access to the technology. Neuroscientists at New York University can identify from one to thousands of proteins of interest, modification of these proteins such as phosphorylation, glycosylation, proteolysis and lipids, perform functional proteomics studies to identify the proteins involved in key signal transduction processes in neurons, and characterize protein-protein interactions by surface plasmon resonance.

Here is a partial list of ongoing projects involving characterization of proteins responsible for key neuronal processes or disorders:

  • Steve Burden: role of signaling by MUSK in the neuromuscular synapse; protein clustering at the neuromuscular synapse
  • Moses Chao: neurotrophin signaling
  • Mitchell Chesler: Dynamics and effects of pH regulation in the brain
  • David Chiu: Neuroregeneration
  • Matthew Dalva (Thomas Jefferson University): Ephrin phosphoproteomics
  • Jeremy Dasen: Control of motor neuron identity and connectivity
  • Gordon Fishell: Development and integration of early born sst expressing interneurons
  • Robert Froemke: Role of oxytocin in maternal behavior
  • Wenbiao Gan: Experience-dependent plasticity of synaptic structure; in vivo studies of microglial functions in brain plasticity and pathology
  • Jorge Ghiso: Characterization of beta amyloid peptides
  • Barbara Hempstead (Weill Cornell): molecular mechanisms of neurotrophin signaling
  • Konstantin Ichtchenko: B anthracis toxin PTM characterization
  • Bryen Jordan (Albert Einstein CoM): Activity-dependent changes in PSD composition
  • Eric Kandel (Columbia University): mechanisms of synaptic plasticity
  • Eric Klann: eif2alpha phosphorylation in synaptic plasticity, memory, and brain disorders; translational control in synaptic plasticity and memory
  • Holger Knaut: Molecular regulation of trigeminal sensory ganglia by SDF1 in zebrafish
  • Cary Lai (Indiana University): neuregulin-ErbB signaling
  • Francis Lee (Weill Cornell) Functional analysis of variant bdnf (val66met)
  • Efrat Levy (NYU/NKI): Characterization of exosomes in Alzheimer’s disease
  • Paul Matthews (NYU/NKI): role of ApoE alleles in Alzheimer’s susceptibility; mechanism of increased risk for Alzheimer’s disease in diabetes
  • Simon Moller (St. John’s University): role of synuclein in Parkinson’s disease
  • Randy Nixon (NYU/NKI): Neurofilament phosphorylation
  • Niels Ringstad: molecular mechanisms of functioning of sensory neurons in C. elegans
  • Hyung Don Ryoo: retinal degeneration
  • Dimitris Placantonakis: Metabolomics and proteomics of gliomagenesis
  • Bernardo Rudy: Molecular components of a-type k+ channels; Development and function of 5ht3ar-expressing cortical gabaergic interneurons
  • Martin Sadowski: Physical interaction between apoE and Abeta
  • Jim Salzer: Phosphoproteomics of neuronal stimulation; Mechanisms of node of ranvier assembly
  • Einar M. Sigurdsson: Epitope-specific targeting of tau aggregates
  • Nicholas Stavropoulos: Mechanism of sleep in drosophila
  • Richard Tsien: Modulation of neurotransmission by Ca++ and activity
  • Clarissa L. Waites (Columbia SOM): Molecular pathway for synaptic vesicle maintenance and degradation
  • Ed Ziff: AMPAR-associated proteins and synaptic plasticity; PSD changes in aging mice

For more information, visit the core website

Contact Us
Dr. Thomas Neubert
Email: thomas.neubert@nyumc.org 
Phone: 212-263-7265

Rodent Behavior Core

The Rodent Behavior Core provides facilities and equipment for:

  • Spatial Learning and Memory (Morris Water Maze, Place Preference)
  • Associative Memory Formation (Fear Conditioning)
  • Anxiety and Depression (Elevated Plus, Forced Swim, Tail Suspension, Sucrose Preference)
  • Sensory Motor Gating (Prepulse Inhibition, Acoustic Startle) 
  • Drug Addiction and Withdrawal (Conditioned Place Preference, Locomotor Hyperactivity) 
  • Social Learning (Three Chambered Arena) 
  • Novelty Detection (Objection Recognition) 
  • Motor Learning (Rotating Rod test)
  • Perseverative Learning (Y-Maze) 
  • Working Memory (Radial Arm Maze) 
  • Real time video tracking to adapt user designed paradigms

For more information, visit the core website

Contact Us
Dr. Adam Mar
Email: adam.mar@nyumc.org
Phone: 212-263-9295

Cores

The Office of Collaborative Science (Cores) oversees the major core resource labs throughout the Medical Center and ensure that investigators have access to, and in some areas even pioneer, new enabling technologies for research. 

Click here for a list of all Cores and shared resources.