Pediatric Cardiology Research | NYU Langone Health

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Division of Pediatric Cardiology Pediatric Cardiology Research

Pediatric Cardiology Research

Researchers in NYU Langone’s Division of Pediatric Cardiology are pioneers in three-dimensional advanced cardiac imaging and printing for cardiac congenital heart disease. Along with investigators in the Congenital Heart Program, the division works with this advanced technology for precise assessment of preintervention anatomy and surgery simulation. The dedicated Congenital Cardiovascular Care Unit provides clinical research opportunities to improve specialized treatment for children with cardiovascular disease.

The division collaborates with the New York City Office of Chief Medical Examiner to investigate genetic causes of sudden cardiac death. One of the aims is to understand the role of genetic mutations in sudden death in patients with no clinical history of cardiac abnormalities.

Division members are investigating how rare genetic mutations in cardiac genes produce arrhythmias. Another area of investigation is the development of a system that allows obstetricians to image fetal hearts at 12 to 16 weeks gestation, allowing for early consultation with fetal cardiac specialists. Quality-of-life research is also being conducted to determine the effects of multiple procedures and hospitalizations on patients with heart disease.

Every quarter, the division’s global team of researchers screens pediatric patients in Trinidad for cardiac conditions.

Recent Publications

An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract

Yamaguchi, Naoko; Chang, Ernest W; Lin, Ziyan; Shekhar, Akshay; Bu, Lei; Khodadadi-Jamayran, Alireza; Tsirigos, Aristotelis; Cen, Yiyun; Phoon, Colin K L; Moskowitz, Ivan P; Park, David S

Circulation. 2023 Nov 21; 148:1705-1722

Three decades of collaboration through the Pediatric Heart Transplant Society Registry: A journey through registry data with a highlight on children with single ventricle anatomy

Richmond, Marc E; Conway, Jennifer; Kirklin, James K; Cantor, Ryan S; Koehl, Devin A; Lal, Ashwin K; McDonald, Nancy; Gajarski, Robert; Lin, Kimberly Y; Singh, Rakesh K; Fenton, Matthew; Asante-Korang, Alfred; Amdani, Shahnawaz; Auerbach, Scott R; Everitt, Melanie D

Pediatric transplantation. 2023 Oct 09; e14615

Cardiolipin prolongs the lifetimes of respiratory proteins in Drosophila flight muscle

Ren, Mindong; Xu, Yang; Phoon, Colin K L; Erdjument-Bromage, Hediye; Neubert, Thomas A; Schlame, Michael

Journal of biological chemistry. 2023 Sep 08; 105241

TGFβ-2 Haploinsufficiency Causes Early Death in Mice with Marfan Syndrome

Sachan, Nalani; Phoon, Colin K L; Zilberberg, Lior; Kugler, Matthias C; Ene, Taylor; Mintz, Shana B; Murtada, Sae-Il; Weiss, Dar; Fishman, Glenn I; Humphrey, Jay D; Rifkin, Daniel B

Matrix biology. 2023 Aug ; 121:41-55

QT Interval Prolongation with One or More QT-Prolonging Agents Used as Part of a Multidrug Regimen for Rifampicin-Resistant Tuberculosis Treatment: Findings from Two Pediatric Studies

Ali, Ali Mohamed; Radtke, Kendra K; Hesseling, Anneke C; Winckler, Jana; Schaaf, H Simon; Draper, Heather R; Solans, Belén P; van der Laan, Louvina; Hughes, Jennifer; Fourie, Barend; Nielsen, James; Garcia-Prats, Anthony J; Savic, Rada M

Antimicrobial agents & chemotherapy. 2023 Jul 18; 67:e0144822

Developing a new pediatric extracorporeal membrane oxygenation (ECMO) program

Cicalese, Erin; Meisler, Sarah; Kitchin, Michael; Zhang, Margaret; Verma, Sourabh; Dapul, Heda; McKinstry, Jaclyn; Toy, Bridget; Chopra, Arun; Fisher, Jason C

Journal of perinatal medicine. 2023 Jun 27; 51:697-703

The critical role of cardiolipin in metazoan differentiation, development, and maturation

Olivar-Villanueva, Melissa; Ren, Mindong; Schlame, Michael; Phoon, Colin K L

Developmental dynamics. 2023 Jun ; 252:691-712

Why Don't More Mitochondrial Diseases Exhibit Cardiomyopathy?

Singh, Nina; Ren, Mindong; Phoon, Colin K L

Journal of cardiovascular development & disease. 2023 Apr 01; 10: