Pediatric Gastroenterology & Hepatology Research | NYU Langone Health

Division of Pediatric Gastroenterology & Hepatology Pediatric Gastroenterology & Hepatology Research

Pediatric Gastroenterology & Hepatology Research

Investigators in NYU Langone’s Division of Pediatric Gastroenterology and Hepatology work to advance the understanding of and treatments for gastrointestinal diseases in children. Research in the division focuses on a range of conditions, including celiac disease, inflammatory bowel disease (IBD), eosinophilic esophagitis, and fatty liver disease.

Faculty members study the effects of celiac disease on the kidneys; quality of life for children with celiac disease, as well in their families; and the environmental triggers of the condition. In addition, faculty have reported evidence suggesting an association between type 1 diabetes and celiac disease.

Research activities on IBD involve performing metabolic analyses and studying treatment responses in children with IBD. The research also includes advanced understanding of immune response in children with this chronic condition, and faculty are working on projects designed to improve quality of life for patients with IBD.

Investigators are studying microscopic changes seen in eosinophilic esophagitis and patient responses to therapy. They have also identified inflammatory responses in eosinophilic esophagitis that are related to the overexpression of growth factors.

The division’s research on fatty liver disease involves study of the condition in underserved patient populations. Investigators continue to measure inflammation in feeding disorders, including a study of pediatric dysphagia caused by rare congenital malformations called esophageal bronchogenic cysts.

Recent Publications

Baseline Drug Clearance Predicts Outcomes in Children With Inflammatory Bowel Disease Treated With Vedolizumab: Results From the VedoKids Prospective Multicentre Study

Stein, Ronen; Turner, Dan; Hussey, Séamus; Kawasmi, Aysha; Ledder, Oren; Levine, Jeremiah; Markowitz, James; Matar, Manar; Orlanski-Meyer, Esther; Russell, Richard K; Shaoul, Ron; Yerushalmy-Feler, Anat; Mould, Diane R; Conrad, Maire A

Alimentary pharmacology & therapeutics. 2025 Mar ; 61:1000-1010

Baseline Drug Clearance Predicts Outcomes in Children With Inflammatory Bowel Disease Treated With Vedolizumab: Results From the VedoKids Prospective Multicentre Study

Stein, Ronen; Turner, Dan; Hussey, Séamus; Kawasmi, Aysha; Ledder, Oren; Levine, Jeremiah; Markowitz, James; Matar, Manar; Orlanski-Meyer, Esther; Russell, Richard K; Shaoul, Ron; Yerushalmy-Feler, Anat; Mould, Diane R; Conrad, Maire A

Alimentary pharmacology & therapeutics. 2025 Mar ; 61:1000-1010

Postvaccination Immunogenicity Among Pediatric Solid Organ Transplant Recipients

Feldman, Amy G; Beaty, Brenda L; Ferrolino, Jose A; Maron, Gabriela; Ali, Saira A; Bitterfeld, Leandra; Blatt, Adam; Boulware, Mary Alice; Campbell, Kathleen M; Carr, Emily; Cetin, Benhur; Chapman, Shelley; Chang, Yeh-Chung; Cunningham, Ryan; Dallas, Ronald H; Dantuluri, Keerti L; Domenick, Bryanna N; Ebel, Noelle H; Elisofon, Scott; Fawaz, Rima; Foca, Marc; Gans, Hayley A; Gopalareddy, Vani V; Gupta, Nitika A; Harmann, Katherine; Hollenbeck, Jessica; Huppler, Anna R; Jaramillo, Catalina; Kasi, Nagraj; Kerkar, Nanda; Lerret, Stacee; Lobritto, Steven J; Lopez, M James; Mavis, Alisha; Mehra, Sonia; Mohandas, Sindhu; Munoz, Flor M; Mysore, Krupa R; Ovchinsky, Nadia; Perkins, Kerrigan; Postma, Stacy; Pratscher, Lauren; Rand, Elizabeth B; Rowe, Regina K; Ruderfer, Daniel; Schultz, Danielle; Sear, Katherine; Sell, Megan L; Sharma, Tanvi S; Stoll, Janis; Turner, Jerry; Valencia Deray, Kristen G; Villarin, Dominique; Weaver, Carly; Wood, Phoebe; Woodford-Berry, Olivia; Yanni, George; Danziger-Isakov, Lara A

JAMA pediatrics. 2025 Feb 24;

The change of alanine aminotransferase distributions among US youths, NHANES 1988-2020

Mallhi, Arshpreet Kaur; Kiely, Keagan; Roy, Victoria; Ovchinsky, Nadia; Woo Baidal, Jennifer A; Rochani, Haresh; Zhang, Jian

Journal of pediatric gastroenterology & nutrition. JPGN. 2025 Jan 13;

Cytomegalovirus (CMV) Prophylaxis in Pediatric Liver Transplantation (PLT): A Comparison of Strategies Across the SPLIT Consortium

Knackstedt, Elizabeth D; Anderson, Sarah G; Anand, Ravinder; Mitchell, Jeff; Arnon, Ronen; Book, Linda; Ekong, Udeme; Elisofon, Scott A; Furuya, Katryn; Himes, Ryan; Jain, Ajay K; Ovchinsky, Nadia; Sundaram, Shikha S; Bucuvalas, John; Danziger-Isakov, Lara; ,

American journal of transplantation. 2024 Oct 03;

Efficacy and safety of odevixibat in patients with Alagille syndrome (ASSERT): a phase 3, double-blind, randomised, placebo-controlled trial

Ovchinsky, Nadia; Aumar, Madeleine; Baker, Alastair; Baumann, Ulrich; Bufler, Philip; Cananzi, Mara; Czubkowski, Piotr; Durmaz, Özlem; Fischer, Ryan; Indolfi, Giuseppe; Karnsakul, Wikrom W; Lacaille, Florence; Lee, Way S; Maggiore, Giuseppe; Rosenthal, Philip; Ruiz, Mathias; Sokal, Etienne; Sturm, Ekkehard; van der Woerd, Wendy; Verkade, Henkjan J; Wehrman, Andrew; Clemson, Christine; Yu, Qifeng; Ni, Quanhong; Ruvido, Jessica; Manganaro, Susan; Mattsson, Jan P

Lancet. Gastroenterology & hepatology. 2024 Jul ; 9:632-645

Maralixibat in progressive familial intrahepatic cholestasis (MARCH-PFIC): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Miethke, Alexander G; Moukarzel, Adib; Porta, Gilda; Covarrubias Esquer, Joshue; Czubkowski, Piotr; Ordonez, Felipe; Mosca, Antonella; Aqul, Amal A; Squires, Robert H; Sokal, Etienne; D'Agostino, Daniel; Baumann, Ulrich; D'Antiga, Lorenzo; Kasi, Nagraj; Laborde, Nolwenn; Arikan, Cigdem; Lin, Chuan-Hao; Gilmour, Susan; Mittal, Naveen; Chiou, Fang Kuan; Horslen, Simon P; Huber, Wolf-Dietrich; Jaecklin, Thomas; Nunes, Tiago; Lascau, Anamaria; Longpre, Lara; Mogul, Douglas B; Garner, Will; Vig, Pamela; Hupertz, Vera F; Gonzalez-Peralta, Regino P; Ekong, Udeme; Hartley, Jane; Laverdure, Noemie; Ovchinsky, Nadia; Thompson, Richard J

Lancet. Gastroenterology & hepatology. 2024 Jul ; 9:620-631

Oral vancomycin is associated with improved inflammatory bowel disease clinical outcomes in primary sclerosing cholangitis-associated inflammatory bowel disease (PSC-IBD): A matched analysis from the Paediatric PSC Consortium

Ricciuto, Amanda; Liu, Kuan; El-Matary, Wael; Amin, Mansi; Amir, Achiya Z; Aumar, Madeleine; Auth, Marcus; Di Guglielmo, Matthew D; Druve Tavares Fagundes, Eleonora; Rodrigues Ferreira, Alexandre; Furuya, Katryn N; Gupta, Nitika; Guthery, Stephen; Horslen, Simon P; Jensen, Kyle; Kamath, Binita M; Kerkar, Nanda; Koot, B G P; Laborda, Trevor J; Lee, Christine K; Loomes, Kathleen M; Mack, Cara; Martinez, Mercedes; Montano-Loza, Aldo; Ovchinsky, Nadia; Papadopoulou, Alexandra; Perito, Emily R; Sathya, Pushpa; Schwarz, Kathleen B; Shah, Uzma; Shteyer, Eyal; Soufi, Nisreen; Stevens, James Patrick; Taylor, Amy; Tessier, M Elizabeth; Valentino, Pamela; Woynarowski, Marek; Deneau, Mark; ,

Alimentary pharmacology & therapeutics. 2024 May ; 59:1236-1247