Investigators in Perlmutter Cancer Center’s Tumor Immunology Research Program publish high-impact studies in leading scientific journals.

Deng J … Wong KK. CDK4/6 inhibition augments antitumor immunity by enhancing T-cell activation. Cancer Discov. 2018. DOI.

Adeegbe DO … Wong KK. Synergistic immunostimulatory effects and therapeutic benefit of combined histone deacetylase and bromodomain inhibition in non-small cell lung cancer. Cancer Discov. 2017. DOI.

Balar AV … Bellmunt J. First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study. Lancet Oncol. 2017. DOI.

Daley D … Miller G. Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance. Nat Med. 2017. DOI.

Daley D … Miller G. NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma. J Exp Med. 2017. DOI.

Fang V … Schwab SR. Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-gamma response. Nat Immunol. 2017. DOI.

Frey AB. The inhibitory signaling receptor protocadherin-18 regulates tumor infiltrating CD8+ T-cell function. Cancer Immunol Res. 2017. DOI.

Jang J-E … Bar-Sagi D. Crosstalk between regulatory T cells and tumor-associated dendritic cells negates anti-tumor immunity in pancreatic cancer. Cell Rep. 2017. DOI.

Mendoza A … Schwab SR. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. Nature. 2017. DOI.

Peters BA … Ahn J. Oral microbiome composition reflects prospective risk for esophageal cancers. Cancer Res. 2017. DOI.

Romero R … Papagiannakopoulos T. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. Nat Med. 2017. DOI.

Ruiz VE … Blaser MJ. A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity. Nat Commun. 2017. DOI.