DEPARTMENT OF PEDIATRICS

Mentors, Participants and Projects

Program Directors

  • Pradeep Mally, M.D. – Division Chief, Neonatology; Director, Neonatal-Perinatal Fellowship Program; JCE Program Co-Director
  • Sean M. Bailey, M.D – Medical Director, Tisch Hospital NICU; Director, JCE Program Co-Director

Neonatal Care Mentors

Faculty

Administrative Staff

  • Claudia Torres - JCE Program Coordinator
  • Lauren Paletti - Neonatology Administrator

Past Participants

2019

Retrospective review on the implementation and outcomes of a dextrose gel protocol for the treatment of transient neonatal hypoglycemia  

By Priyanshi Jain, Kayla Rebetti and Marissa Rice  

Our primary objective is to assess if there was a change in intravenous fluid (IVF) administration rates after implementation of our institution’s dextrose gel protocol. Our secondary outcomes include assessing a change in NICU admission rates and incidence of hyperglycemia between our utilization of weight based dosing to standardized dosing of dextrose gel, variations in efficacy of dextrose gel based on hypoglycemia risk factors, and difference in rates of discharge home from the newborn nursery with exclusive breastfeeding after implementation of this protocol.

Maturational characteristics of the host response to GBS intestinal colonization  

By Luis De Bernardis, Nermeen Kidwai and Jonathan Slimovitch

Group B Streptococcus (GBS) is a leading cause of infectious morbidity during infancy. Maternal rectovaginal colonization serves as the major reservoir for GBS and transmission to the newborn typically occurs in the perinatal or early post-natal periods. The widespread implementation of intrapartum antibiotic prophylaxis of GBS colonized mothers has drastically reduced the incidence of early-onset infection (occurring in the first week of life). However, the incidence of late-onset (LO) infection (>7 days of age) remains unchanged and it is now the most common manifestation of invasive GBS disease in the United States and other regions of the world that have adopted similar intrapartum prophylaxis strategies.

Postnatal Growth Trajectory and Neurodevelopmental Outcomes in Preterm Neonates

By Elizabeth Scott, Bryn Seltzer and Mirella Torresan

Extrauterine growth restriction remains common in preterm infants and may affect neurodevelopmental outcomes. The objective of this study is to look for an association between postnatal growth trajectory and neurodevelopmental outcomes at 18-24 months corrected gestational age in preterm infants born at <32 weeks gestation. We hypothesize that infants with poor growth trajectories, as determined by lower Z-score slopes, will have worse neurodevelopmental outcomes when compared to those with normal or high z-score slopes. 

2018

A Single Center's Experience with the 7th Edition NRP Recommendations for Meconium Stained Amniotic Fluid

By Destini Goodly and Halle Paredes

The study objective was to investigate whether there was a change in incidence and severity of meconium aspiration syndrome at our institution after the implementation of the 7th edition NRP recommendations. The research team hypothesized that the rate of NICU admissions and severity of disease for infants born through meconium stained amniotic fluid will be unchanged after the implementation of the 7th edition NRP recommendations. 

Retrospective Criteria For Cannulation in a New Pediatric Extracorporeal Membrane Oxygenation (ECMO) Program

By Michael Kitchin and Margaret Zhang

The NYU Pediatric Extracorporeal Membrane Oxygenation (ECMO) Program started in March 2015 and since then has been consulted on 69 patients and has put 19 patients on ECMO.  This study looked at all of the consulted patients, to see what differences exist between those who received ECMO and those who did not. The research team looked for differences in historically used physiologic criteria, echocardiogram parameters, and medication use. They hypothesized that the paO2 and O2 saturations would be lower, and the oxygenation index would be higher, in the patients who received ECMO than in those who did not.

The Effect of Donor Breast Milk on Postnatal Growth and Metabolic Bone Disease in Premature Infants

By Shanice Boyce and Kara Jordon

Donor breast milk is a valuable asset for preterm infants when mother's milk is contraindicated or unavailable. However, donor breast milk is pasteurized and loses calcium and phosphorus, among other nutrients, during that process. The study objectives were to determine if donor breast milk had an effect on bone mineralization, growth, and neonatal comorbidities in preterm infants. The research team hypothesized that preterm infants who received donor breast milk would have an increased prevalence of metabolic bone disease and decreased postnatal growth.

2017

Neurodevelopment outcomes of very preterm and extremely preterm infants

by Nicholas Santaniello and Paige William

Scholars used data collected at the NYU Neonatal Comprehensive Care Program (NCCP) follow up clinic to assess neurodevelopment at 6, 12, 18, and 24 months in our sample population. They used the Bayley Scales of Infant and Toddler Development III to specifically get a better understanding of the correlation between gestational age and the cognitive, motor, and language development in this cohort. They also analyzed the secondary outcomes that may have affected neurodevelopment (i.e., intraventricular hemorrhage, peri-ventricular leukomalacia, and retinopathy of prematurity).

The Impact of Antenatal Corticosteroids on Neonatal Morbidities in Late Preterm and Early Term Neonates

by Julia Katz, Rebecca Trillo and Kiran Bhutada

Preterm infants are at a greater risk than term infants for neonatal complications such as low birth weight, respiratory distress, and hypoglycemia. For many years the American College of Obstetrics and Gynecology has recommended the administration of antenatal corticosteroids (ACS) to women at risk of birth before 34 weeks gestation in order to prevent respiratory morbidities. In June 2016, the ACOG changed their guidelines to also include the administration of ACS to women at risk of late preterm birth (34-37 weeks gestation). Recent studies have shown that early term infants (37-38 weeks gestation) may also benefit from ACS. This study looked at the effects of ACS administration on the incidence of respiratory morbidities in late preterm and early term infants born at NYU Langone Medical center between June 2015 and June 2017.

Group B Streptococcus Serotype Distribution among Colonized Women

by Margaret Gegick and Evan Suzman

Maternal Group B Streptococcus (GBS) colonization is the major risk factor for invasive neonatal disease. Maternal immunization against GBS represents an appealing strategy for disease prevention. Current vaccine candidates are serotype specific, therefore it is critical to understand the distribution of GBS serotypes globally. The objectives of this study was to determine the prevalence of each of the ten GBS serotypes in geographically distinct populations (New York City, USA; Gaborone and Ramotswa, Botswana) using real-time PCR methodology and to determine the percentage of women colonized with multiple serotypes.

2016

The Effect of Preeclampsia on Neuro-Developmental Outcomes In Pre-Term Neonates

by Anita Matthew and Sydney Berger

Using the Mullen's Scales of Early Learning ,we have assessed and evaluated neurodevelopment in infants born to preeclampsic mothers at 12- and 18-months who have visited the Neonatal Comprehensive Care Program at NYU Langone Medical Center. 

Assessing Value of Routine Diagnostic Laboratory Testing in the NYULMC NICU

by Henna Boolchandani and Madison Friedman

The study objective was to determine whether the current practice of obtaining routine hemograms and hepatic profiles improves patient care, or whether these tests are adding cost and placing a burden of undergoing nonessential testing on NICU patients. The research team hypothesized that routine hemograms and hepatic profiles in the NICU are unnecessary and add cost without improving the clinical outcome of neonates.

Real-time PCR-based Serotyping of Streptococcus agalactiae

by David Lee, Bhavana Ragipani and Martin Malik

This project is focused on the development and validation of a novel technique to serotype Streptococcus agalactiae (Group B Streptococcus), an important neonatal pathogen. This robust and efficient tool is an attractive alternative to current serotyping methods and will allow for improved acquisition of GBS serotype data that will inform future vaccine development.

2015

Diagnostic Dilemma: The Asymptomatic Neonate with Maternal Chorioamnionitis

by Minh-Thu Tran and Arushi Jauhari

This study looked at what is the best time to obtain blood tests in asymptomatic infants admitted to the nicu for antibiotic therapy. The results showed that it may be better to wait several hours after a baby is born to get more clear results rather to test a baby's blood right away.

Neurodevelopmental Outcomes in Very Low Birth Weight Preterm Infants

by Pooja Pate, Marc Moscatelli and Melissa Moran

This study looked at what impact being born very preterm had on infants born in the nicu had on development. The studies showed that being burn very preterm may currently be associated with better outcomes than in the past.

Phototherapy in the Neonatal Intensive Care Unit Setting

by Sara Zhang and Oladunni Ogundipe

This study looked at what impact ordering phototherapy in various manners had on irradiance levels of energy that infants were exposed to in the hospital for jaundice treatment. This study shows how newer ways of ordering this therapy may be improved to provide ideal care.

2014

A prospective observation pilot study analyzing variation in Irradiance administered during the use of phototherapy to treat Hyperbilirubinemia in newborn infant

by Karen Yan, Kyle Richardson and Rachel Friedlander

This study explored the use of various types of phototherapy equipment currently used in neonatal care to treat hyperbiliribunemia / jaundice of infancy. The results found that there is a high degree of variation in light levels that infants treated with this therapy may receive depending on what type of equipment is used and in what manner it is employed.

Change in NICU Apnea Discharge Policy and its impact on length of stay

by Christine Tolias, Bella Guinea and Hannah Fagen

This study looked at what impacts stopping the use of home monitoring systems that infants in some centers had been sent home on when born preterm had on various aspects of clinical care. The results focused on the impact on length of stay in the hospital and economic consequences.

Does Indomethacin Prophylaxis usage have an impact on outcomes in extremely low birth weight (ELBW) preterm infants?: A retrospective chart review

by Elaine Carelus and Katherine Carome

This study examined whether the use of a medication (indomethacin) used in preterm infants to close a patent ductis arteriousus (a heart vessel that can remain open in preterm infants and have a negative impact on body health) should be given right after a baby is born or later in an infant’s course. The results demonstrated that using this medication right away may not add any benefit and is likely not necessary treatment.