Molecular Oncology

Molecular Oncology research has been a consistent focal point for pathologists at NYU, and pathology faculty members in this program are central to the research initiatives of the new NYU Cancer Institute. Faculty members in our Molecular Oncology Program have long been interested in the genetic basis of neoplastic transformation, with research covering the gamut from genomic instability and DNA repair to the role of oncogenes and tumor suppressors, gene therapy for cancer, and regulation of the cell cycle. One of our Adjunct Professors, Avram Hershko, received the 2004 Nobel Prize in Chemistry for co-discovering ubiquitin-mediated protein instability, one of the key controls of the cell cycle. Much of our work in Molecular Oncology has direct clinical ties.

Current core faculty members pursue research in the following areas: Regulation of cell cycle progression; Regulation of gene expression with an emphasis on signal transduction from the cell exterior and the impact of oncogenic transformation on signaling and gene expression; Understanding molecular targets of oncogenes, with tie-ins to mechanisms of genomic instability, DNA repair and DNA damage checkpoints; Molecular biology of telomere maintenance, including mechanisms responsible for preventing oncogenic events such as telomere-telomere fusions and mechanisms to ensure proper chromosome segregation during mitosis; vector and gene delivery biotechnology and vectors for advanced pancreatic cancer therapy; and Invasion, angiogenesis in malignant gliomas, and novel therapies.

Related links:
MOI Training Program